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Chemical Structure| 1574395-48-4 Chemical Structure| 1574395-48-4

Structure of 1574395-48-4

Chemical Structure| 1574395-48-4

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Product Details of [ 1574395-48-4 ]

CAS No. :1574395-48-4
Formula : C8H5BrN2O
M.W : 225.04
SMILES Code : O=C1NC2=C(C=NC(Br)=C2)C=C1
MDL No. :MFCD29048690

Safety of [ 1574395-48-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 1574395-48-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1574395-48-4 ]

[ 1574395-48-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1574395-48-4 ]
  • [ 33024-60-1 ]
  • [ 1574395-49-5 ]
YieldReaction ConditionsOperation in experiment
75% With palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; lithium hexamethyldisilazane; In tetrahydrofuran; for 2h;Inert atmosphere; Reflux; A 5 L 4-necked round-bottom flask purged and maintained with a N2 atmosphere was charged with A-6 (100 g, 444.36 mmol, 1.00 equiv), Pd(OAc)2 (10 mg, 0.04 mmol, 0.10 equiv), Xantphos (25.8 g, 44.56 mmol, 0.10 equiv), <strong>[33024-60-1]tetrahydro-2H-pyran-4-amine hydrochloride</strong> (67 g, 486.88 mmol, 1.10 equiv), and THF (1 L), and then a solution of LiHMDS (1 M on THF) (2000 mL, 4.50 equiv) was added. The resulting solution was heated to reflux for 2 h, concentrated in vacuo, diluted with 4 L of water and extracted with EtOAc (2×2 L). The aqueous layers were combined, and the pH adjusted to 89 with NaHCO3 (solid). The precipitates were collected by filtration and dried in an oven in vacuo to afford 81.7 g (75percent) of A-7 (R2=tetrahydro-2H-pyran-4-yl) as a yellow solid
 

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