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[ CAS No. 158001-24-2 ] {[proInfo.proName]}

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Chemical Structure| 158001-24-2
Chemical Structure| 158001-24-2
Structure of 158001-24-2 * Storage: {[proInfo.prStorage]}
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Product Details of [ 158001-24-2 ]

CAS No. :158001-24-2 MDL No. :MFCD16658754
Formula : C4H11ClN2O Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 138.60 Pubchem ID :-
Synonyms :

Safety of [ 158001-24-2 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
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Application In Synthesis of [ 158001-24-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 158001-24-2 ]
  • Downstream synthetic route of [ 158001-24-2 ]

[ 158001-24-2 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 158001-24-2 ]
  • [ 5417-82-3 ]
  • [ 57595-23-0 ]
  • [ 158001-25-3 ]
YieldReaction ConditionsOperation in experiment
54% With sodium methylate In ethanol (e)
1-(3-Tetrahydrofuranyl)-3-methyl-5-amino-1H-pyrazole-4-carbonitrile
A mixture of 3-tetrahydrofuranylhydrazine hydrochloride (6.2 g, 0.045 mol), sodium methoxide (2.4 g, 0.045 mol) and ethanol (70 ml) was refluxed under argon for 10 minutes.
The reaction mixture was cooled to room temperature and 1-ethoxyethylidene malononitrile (6.1 g, 0.045 mol) was added.
The reaction mixture was heated to reflux and stirred for 21 hours.
The reaction was cooled and the solvent was removed in vacuo.
The residue was recrystallized from water to afford 4.7 g (54percent) of 1-(3-tetrahydrofuranyl)-3-methyl-5-amino-1H-pyrazole-4-carbonitrile as yellow crystals, m.p. 134°-135° C. when dried at 90° C. in high vacuum.
Reference: [1] Patent: US5294612, 1994, A,
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