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Chemical Structure| 158063-66-2 Chemical Structure| 158063-66-2
Chemical Structure| 158063-66-2

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Product Details of 4-(Trifluoromethyl)nicotinic acid

CAS No. :158063-66-2
Formula : C7H4F3NO2
M.W : 191.11
SMILES Code : FC(C1=C(C=NC=C1)C(=O)O)(F)F
MDL No. :MFCD00082626
InChI Key :LMRJHNFECNKDKH-UHFFFAOYSA-N
Pubchem ID :2777549

Safety of 4-(Trifluoromethyl)nicotinic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of 4-(Trifluoromethyl)nicotinic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 158063-66-2 ]

[ 158063-66-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 158063-66-2 ]
  • [ 81565-19-7 ]
YieldReaction ConditionsOperation in experiment
With thionyl chloride; In toluene; at 50 - 80℃; for 3h; In a 250 ml four-necked flask equipped with a reflux condenser, a thermometer and a dropping funnel, 30.0 g (0.157 mol) of 4-(trifluoromethyl)nicotinic acid, 100 ml of toluene, heated to 50-60 C, and dripped 28.0 g (0.235 mol) of thionyl chloride was added, and the addition was completed in about 1 hour. After the dropwise addition was completed, the temperature was raised to 80 C for 2 hours, and the reaction was completed to obtain a 4-(trifluoromethyl)nicotinyl chloride solution.
 

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