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Chemical Structure| 159635-23-1 Chemical Structure| 159635-23-1

Structure of 159635-23-1

Chemical Structure| 159635-23-1

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Product Details of [ 159635-23-1 ]

CAS No. :159635-23-1
Formula : C11H18ClNO2
M.W : 231.72
SMILES Code : O=C(N1CCC(CCl)=CC1)OC(C)(C)C
MDL No. :MFCD22377109

Safety of [ 159635-23-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 159635-23-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 159635-23-1 ]

[ 159635-23-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 40263-57-8 ]
  • [ 159635-23-1 ]
  • tert-butyl 4-(((2-iodopyridin-3-yl)oxy)methyl)-3,6-dihydropyridine-1(2H)-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
84% With potassium carbonate; In N,N-dimethyl-formamide; at 70℃; for 12h;Sealed tube; Inert atmosphere; General procedure: A round bottom flask was charged with aryl halide (1.1equiv) and K2CO3 (2.0 equiv). The round bottom was equipped with a stir bar and was sealedwith a red septum stopper. The atmosphere was exchanged by applying vacuum and backfillingwith nitrogen (this process was conducted a total of three times). Under nitrogen atmosphere,DMF (0.1 M) was added via syringe followed by tert-butyl 4- (chloromethyl-3,6-dihydropyridine- 1(2H)-carboxylate (1.0 equiv). The resulting mixture was stirred at 70 C for12 h before being cooled to room temperature. The reaction mixture was diluted with ethylacetate and washed with water (1x 100 mL), 1M NaOH (2x 100mL), and brine (3x 100mL). Theorganic layer was dried over sodium sulfate, filtered, and concentrated via rotary evaporation togive the title compound with no further purification required.
 

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