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Chemical Structure| 1609453-56-6 Chemical Structure| 1609453-56-6

Structure of 1609453-56-6

Chemical Structure| 1609453-56-6

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Product Details of [ 1609453-56-6 ]

CAS No. :1609453-56-6
Formula : C11H11ClN2
M.W : 206.67
SMILES Code : CC1=C2C3=C(C=C1)CCCN3C(Cl)=N2
MDL No. :MFCD28404886

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Application In Synthesis of [ 1609453-56-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1609453-56-6 ]

[ 1609453-56-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1609453-56-6 ]
  • [ 1609452-31-4 ]
YieldReaction ConditionsOperation in experiment
90% With N-Bromosuccinimide; In acetonitrile; at 0 - 20℃; for 49.5h; 7, 8-dibromo-2-chloro-9-methyl-5 ,6-dihydro-4H-imidazo [4,5,1 -]quino line (Method2A) A 2-chloro-9-methyl-5,6-dihydro-4H-imidazo[4,5,1-]quinoline (11.7 g, 56 mmol)(Method 14A) was dissolved in acetonitrile (250 mL) cooled to 0C and next Nbromosuccinimide (50.0 g, 282 mmol) was added portionwise over lh. The reaction mixture was stirred at 0C for 30minutes then at room temperature for 48 hours. The solvent was evaporated under reduced pressure and residue was dissolved in dichloromethane and washed with saturated aqueous solution of sodium hydrogencarbonate. The organic layer was dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated to gave 18.6g of 7,8-dibromo-2-chloro-9-methyl-5,6- dihydro-4H-imidazo[4,5,1-]quinoline; yield 90%; LC-MS (m/z) 364.8 (M+1). 1H NMR (600 MHz, DMSO) oe 4.12 (t, 2H, CH2), 2,88 (t, 2H, CH2), 2.57 (s, 3H, CH3), 2.22-2.18 (m, 2H, CH2).
 

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