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[ CAS No. 16097-62-4 ]

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Chemical Structure| 16097-62-4
Chemical Structure| 16097-62-4
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CAS No. :16097-62-4 MDL No. :MFCD00153191
Formula : C6H5F3N2OS Boiling Point : 205.7°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :210.18 g/mol Pubchem ID :-
Synonyms :

Safety of [ 16097-62-4 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501 UN#:
Hazard Statements:H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 16097-62-4 ]

  • Upstream synthesis route of [ 16097-62-4 ]
  • Downstream synthetic route of [ 16097-62-4 ]

[ 16097-62-4 ] Synthesis Path-Upstream   1~5

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  • [ 672-45-7 ]
Reference: [1] Pest Management Science, 2000, vol. 56, # 1, p. 65 - 73
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YieldReaction ConditionsOperation in experiment
90% at 120℃; for 3 h; A solution of 2- (methylthio) -6- (trifluoromethyl) pyrimidin-4-ol (43-01) (1.4g, 6.67mmol) in POCl3 (15mL) was refluxed at 120 for 3hrs. The reaction mixture was cooled to room temperature, and POCl3 was removed in vacuo. The residue was extracted by DCM and icy H2O 3 times. The organic layer was combined, washed with brine, dried over Na2SO4 and concentrated to give 1.38g of 4-chloro-2- (methylthio) -6- (trifluoromethyl) pyrimidine as a light yellow oid (90) . LC-MS (ESI) m/z: calcd for [C6H5ClF3N2S+] , 229.0, found 229.0.
Reference: [1] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 4, p. 407 - 412
[2] Patent: WO2018/14802, 2018, A1, . Location in patent: Paragraph 0232
[3] Journal of Heterocyclic Chemistry, 1983, vol. 20, # 1, p. 219 - 223
[4] Patent: WO2010/134478, 2010, A1, . Location in patent: Page/Page column 182
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Reference: [1] Journal of Heterocyclic Chemistry, 1983, vol. 20, # 1, p. 219 - 223
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Reference: [1] Journal of Heterocyclic Chemistry, 1983, vol. 20, # 1, p. 219 - 223
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  • [ 85730-36-5 ]
Reference: [1] Journal of Heterocyclic Chemistry, 1983, vol. 20, # 1, p. 219 - 223
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