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Chemical Structure| 161157-50-2 Chemical Structure| 161157-50-2

Structure of 161157-50-2

Chemical Structure| 161157-50-2

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Product Details of [ 161157-50-2 ]

CAS No. :161157-50-2
Formula : C10H17NO3
M.W : 199.25
SMILES Code : O=C(N1CC2OC2CC1)OC(C)(C)C
MDL No. :MFCD12407050
Boiling Point : No data available
InChI Key :MMPWHAJQEZIIEH-UHFFFAOYSA-N
Pubchem ID :21991116

Safety of [ 161157-50-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 161157-50-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 161157-50-2 ]

[ 161157-50-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 100-59-4 ]
  • [ 161157-50-2 ]
  • [ 1000931-04-3 ]
YieldReaction ConditionsOperation in experiment
94% According to Tetrahedron Lett., 1979, 17, 1503, to a stirred solution of phenylmagnesium chloride (0.753 mL, 1.51 mmol) and copper (I) iodide (0.0191 g, 0.100 mmol) in THF (3 mL) at -300C was added tert-butyl 7-oxa-3-aza- bicyclo[4.1.0]heptane-3-carboxylate (0.200 g, 1.00 mmol) in THF (1 mL) . The mixture was allowed to warm to room temperature and was stirred for 16 h. It was then quenched with saturated aqueous ammonium chloride and the mixture was extracted with AcOEt. The combined organic layers were dried (sodium sulfate) , filtered, and concentrated in vacuo to give tert-butyl 3-hydroxy-4-phenylpiperidine-l-carboxylate (0.261 g, 94%) as an oil: 1H NMR (400 MHz, DMSO-d6) delta 1-49 (s, 9H), 1.76 (m, 3H), 2.50-2.78 (m, 3H), 3.70 (m, IH), 4.30 (bd, IH), 7.30 (m, 5H).
  • 2
  • [ 161157-50-2 ]
  • [ 224779-27-5 ]
 

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