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Chemical Structure| 1613192-96-3 Chemical Structure| 1613192-96-3

Structure of 1613192-96-3

Chemical Structure| 1613192-96-3

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Product Details of [ 1613192-96-3 ]

CAS No. :1613192-96-3
Formula : C5H3BrCl2FN
M.W : 246.89
SMILES Code : FC1=CN=CC(Br)=C1Cl.[H]Cl
MDL No. :MFCD28805788

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Application In Synthesis of [ 1613192-96-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1613192-96-3 ]
  • Downstream synthetic route of [ 1613192-96-3 ]

[ 1613192-96-3 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 1613192-96-3 ]
  • [ 1211540-92-9 ]
YieldReaction ConditionsOperation in experiment
41 g With sodium hydroxide In dichloromethane for 1 h; Cooling with ice [ 0505] 3 -bromo-4-chloro-5-fluoro-pyridine hydrochloride18 ( 62 g, 251.1 mmol) was suspended in DCM ( 600 mL) andstirred. The mixture was cooled in an ice bath and sodiumhydroxide (276.2 mL of 1 M, 276.2 mmol) was added slowly.The resulting mixture was stirred for 1 hour. The mixture wasphase-separated. More DCM/water was added to aid phaseseparation. Some tarry particulates remained in the aqueousphase. The organic phase was washed with brine, dried(MgS04 ), filtered and concentrated. The residue was trituratedwith heptane. The heptane solution was filtered througha florsil pad, eluting with heptane. The filtrate was concentratedto an oil which solidified. This gave 41 g offree base.
References: [1] Patent: US2015/158872, 2015, A1, . Location in patent: Paragraph 0503; 0505.
 

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