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Chemical Structure| 162401-16-3 Chemical Structure| 162401-16-3

Structure of 162401-16-3

Chemical Structure| 162401-16-3

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Product Details of [ 162401-16-3 ]

CAS No. :162401-16-3
Formula : C10H7N7O
M.W : 241.21
SMILES Code : NC1=NC(NN=C2)=C2C3=NC(C4=CC=CO4)=NN13
MDL No. :MFCD18914402
InChI Key :YKWJNVFPKLFRRE-UHFFFAOYSA-N
Pubchem ID :135485985

Safety of [ 162401-16-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 162401-16-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 162401-16-3 ]

[ 162401-16-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1200828-74-5 ]
  • [ 162401-16-3 ]
  • ethyl 2-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-2-cyclopropylacetate [ No CAS ]
  • ethyl 2-(5-amino-2-(furan-2-yl)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-8-yl)-2-cyclopropylacetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
51.4%; 64.7% With potassium carbonate; In N,N-dimethyl-formamide; at 60℃; To a stirred solution of 2- (furan-2-yl) -7H-pyrazolo [4, 3-e] [1, 2, 4] triazolo [1, 5-c] pyrimidin-5-amine (1.0 g, 4.2 mmol) in DMF (50 mL) was added K2CO3(1.3 g, 9.4 mmol) and <strong>[1200828-74-5]ethyl 2-bromo-2-cyclopropylacetate</strong> (1.2 g, 5.8 mmol) . After the addition, the reaction mixture was stirred overnight at 60 C. The reaction mixture was poured into H2O (50 mL) and extracted with EtOAc (100 mL x 3) . The combined organic layers were washed with brine, dried over Na2SO4, concentrated and purified by column chromatography (petroleum ether/EtOAc = 2: 1 1: 2) to give ethyl 2- (5-amino-2- (furan-2-yl) -7H-pyrazolo [4, 3-e] [1, 2, 4] triazolo [1, 5-c] pyrimidin-7-yl) -2-cyclopropylacetate (400 mg, 51.4%) and ethyl 2- (5-amino-2- (furan-2-yl) -8H-pyrazolo [4, 3-e] [1, 2, 4] triazolo [1, 5-c] pyrimidin-8-yl) -2-cyclopropylacetate (500 mg, 64.7%) as white solids. MS: M/e 368 (M+1)+.
 

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