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Chemical Structure| 163089-34-7 Chemical Structure| 163089-34-7

Structure of 163089-34-7

Chemical Structure| 163089-34-7

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Product Details of [ 163089-34-7 ]

CAS No. :163089-34-7
Formula : C10H23NO3Si
M.W : 233.38
SMILES Code : O=C(N(OC)C)CO[Si](C)(C(C)(C)C)C
MDL No. :MFCD30471948

Safety of [ 163089-34-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 163089-34-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 163089-34-7 ]

[ 163089-34-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 163089-34-7 ]
  • [ 30506-30-0 ]
  • 2-((tert-butyldimethylsilyl)oxy)-1-(4-(ethylthio)phenyl)ethanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
2.02 g In a dry flask with magnesium turnings (525 mg, 21.59 mmol) were added THF (5.0 mL) and five drops of 1,2-dichlororethane and the mixture was slowly heated to 40 C. To that mixture, <strong>[30506-30-0](4-bromophenyl)(ethyl)sulfane</strong> (3.0 g, 10.81 mmol) dropwise was added and stirred for 30 min at 40 C. The reaction mixture was cooled down to 0 C and 2-((tert-butyldimethylsilyl)oxy)- N-methoxy-N-methylacetamide (Step 2 intermediate) (3.78 g, 16.21 mmol) was added to the mixture and stirred for 3 h at the same temperature. The mixture was quenched with saturated aqueous solution of ammonium chloride and extracted twice with ethyl acetate. The combined organic extracts were washed with brine, dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure and the residue obtained was purified by silica gel column chromatography to yield 2.02 g of the desired compound. 1H NMR (300 MHz, CDCl3) δ 0.11 (s, 6H), 0.92 (s, 9H), 1.34 (t, J = 7.2 Hz, 3H), 3.02 (q, J = 7.2 Hz, 2H), 4.86 (s, 2H), 7.29 (d, J = 8.4 Hz, 2H), 7.84 (d, J = 8.4 Hz, 2H); ESI-MS (m/z) 311 (M+H)+.
 

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