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Chemical Structure| 1632-84-4 Chemical Structure| 1632-84-4

Structure of 1632-84-4

Chemical Structure| 1632-84-4

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Product Details of [ 1632-84-4 ]

CAS No. :1632-84-4
Formula : C8H7NOS
M.W : 165.21
SMILES Code : CSC1=CC=C(N=C=O)C=C1
MDL No. :MFCD00013878

Safety of [ 1632-84-4 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H315-H319-H335
Precautionary Statements:P261-P301+P310-P305+P351+P338-P402+P404
Class:6.1
UN#:2206
Packing Group:

Application In Synthesis of [ 1632-84-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1632-84-4 ]

[ 1632-84-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 20876-36-2 ]
  • [ 1632-84-4 ]
  • 1-(4-(methylthio)phenyl)-3-(2-oxoindolin-5-yl)urea [ No CAS ]
YieldReaction ConditionsOperation in experiment
96% In methanol; dichloromethane; at 10 - 20℃; for 4h; To a solution of <strong>[20876-36-2]5-amino-1,3-dihydro-2H-indol-2-one</strong> 17 (148 mg, 1.0 mmol) in 10 mL DCM/MeOH (9:1), 1-isocyanato-4-(methylsulfanyl)benzene (182 mg, 1.1 mmol) was added slowly at 10 °C. The mixture was stirred at the room temperature for 4 h. Solid product 18 was separated out from the mixture. It was filtered, washed with DCM, and air dried. (330 mg, 0.96 mmol, 96percent yield): mp 212-214 °C. 1H NMR: delta 2.43 (s, 3H, SMe); 3.52 (s, 2H, CH2); 6.72 (d, 1H, J = 8.2 Hz, Ar); 7.12-7.23 (m, 3H, Ar); 7.37 (s, 1H, Ar); 7.41 (d, 2H, J = 8.8 Hz, Ar); 8.48 (br s, 1H); 8.62 (br s, 1H); 10.24 (br s, 1H, NH) ppm. 13C NMR: delta 167.93, 158.66, 145.19, 142.75, 133.57, 129.87, 128.45, 127.67, 126.25, 113.33, 109.09; 108.90; 36.71; 15.10 ppm. Anal. (C16H15N3O2S) Calcpercent: C 61.32, H 4.82, N 13.41, S 10.23; Foundpercent: C 61.05, H 4.67, N 13.23, S 10.23.
 

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