163226-45-7|(3AS,4S,6aR)-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-ol| Ambeed

CAS No. :	163226-45-7
Formula :	C₂₈H₂₈O₄
M.W :	428.52
SMILES Code :	O[C@H]1C=C(COC(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)[C@]5([H])[C@@]1([H])OC(C)(C)O5
MDL No. :	MFCD30536586
InChI Key :	HZWCKFPVWSCREB-NXCFDTQHSA-N
Pubchem ID :	10884464

Safety of [ 163226-45-7 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 163226-45-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 163226-45-7 ]

[ 163226-45-7 ] Synthesis Path-Downstream 1~54

1
[ 98-88-4 ]
[ 163226-45-7 ]
(1S,2S,3R)-1-benzoyloxy-2,3-(isopropylidenedioxy)-4-(trityloxymethyl)-4-cyclopentene [ No CAS ]

References: [1]Nucleosides, nucleotides and nucleic acids,2009,vol. 28,p. 504 - 518.
[2]Journal of Medicinal Chemistry,1993,vol. 36,p. 1210 - 1220.

2
[ 88559-56-2 ]
[ 163226-45-7 ]

Yield	Reaction Conditions	Operation in experiment
98%	With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20℃; for 2h;Inert atmosphere;	A solution of 57 22 (81mg, 0.19mmol) in 30 THF (2mL) was added dropwise to a suspension of 59 LAH (36mg, 0.96mmol) in THF (2mL) at 0C. After the reaction was stirred at rt for 2h, 60 H2O (1mL) was added to quench it. After the mixture was stirred at rt for 1h, 61 MgSO4 was added, and the resulting mixture was filtered through Celite and concentrated to give a residue, which was purified using silica gel column chromatography (EtOAc-hexane 1:3) to give 7 2alpha (79mg, 98%, white solid).16 2alpha: 1H NMR (300MHz, CDCl3): delta 1.36 (s, 3H), 1.37 (s, 3H), 2.74 (d, 1H, J=10.2Hz), 3.65 (dt, 1H, J=14.4, 1.8Hz), 3.88 (d, 1H, J=14.4Hz), 4.59 (br, 1H), 4.75 (t, 1H, J=5.4Hz), 4.88 (d, 1H, J=5.4Hz), 6.00 (br, 1H), 7.20-7.32 (m, 9H), 7.44-7.48 (m, 6H).

References: [1]Journal of Organic Chemistry,2005,vol. 70,p. 6884 - 6890.
[2]Tetrahedron,2018,vol. 74,p. 2143 - 2150.
[3]Tetrahedron Letters,1995,vol. 36,p. 1537 - 1538.
[4]Journal of Medicinal Chemistry,2015,vol. 58,p. 5108 - 5120.
[5]Journal of Medicinal Chemistry,1993,vol. 36,p. 1210 - 1220.

3
[ 66224-66-6 ]
[ 163226-45-7 ]
(1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-trityloxymethyl-cyclopent-3-ene-1,2-diol [ No CAS ]

References: [1]Tetrahedron Letters,1995,vol. 36,p. 1537 - 1538.

4
[ 66224-66-6 ]
[ 163226-45-7 ]
9-((3aS,4R,6aR)-4,6a-dihydro-6-((trityloxy)methyl)-2,2-dimethyl-3aH-cyclopenta[d][1,3]dioxol-4-yl)-9H-purin-6-amine [ No CAS ]

References: [1]Journal of Organic Chemistry,2005,vol. 70,p. 6884 - 6890.
[2]Journal of Medicinal Chemistry,2015,vol. 58,p. 5108 - 5120.

5
[ 2770-01-6 ]
[ 163226-45-7 ]
[ 877651-81-5 ]
[ 877651-87-1 ]

Yield	Reaction Conditions	Operation in experiment
20%; 20%	With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at -78 - 20℃; for 24h;Product distribution / selectivity;	The chiral cyclopentenyl moiety 5 (below) was prepared from D-ribose in 8 steps following a previously reported synthetic method via a chiral induction, a regioselective protection of hydroxy group and ring-closing metathesis with 0.1 mole% of the 2nd generation Grubbs catalyst as key steps. 10; The other key intermediate 7 was synthesized according to the previously reported procedure11 from commercially available 4-amino-2-chloropyridine (6) in 4 steps (overall 54% yield) as shown in Scheme 1. Mitsunobu reaction of 7 with 5 provided a mixture of the N9- and N7-regioisomers (8:9 = 2:1) in 94% yield. The separation of the desired product (8) from the reaction mixture was difficult by silica gel column [isolated yields: 20% (8) and 20% (9), respectively]. The ratio of the two isomers was determined by 1H-NMR, and their configuration was identified by Nuclear Overhouser Effect (ID-NOE), which indicated the <n="38"/>interaction between the C1 '-H and the aromatic C3-H of compound 8, whereas the same effect was not present in compound 9.

References: [1]Tetrahedron,2006,vol. 62,p. 1295 - 1300.
[2]Patent: WO2007/47793,2007,A2 .Location in patent: Page/Page column 35.

6
[ 934816-33-8 ]
[ 163226-45-7 ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.

7
[ 17325-26-7 ]
[ 163226-45-7 ]
[ 878479-17-5 ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.

8
[ 76-83-5 ]
[ 162126-83-2 ]
[ 163226-45-7 ]

Yield	Reaction Conditions	Operation in experiment
92%	With triethylamine;dmap; In dichloromethane; at 20℃; for 12h;Product distribution / selectivity;	To a solution of compound 14 (1.0 g, 5.37 mmol), catalytic amount of DMAP (0.07 g, 0.54 mmol) and trityl chloride (1.90 g, 6.71 mmol) in 20 mL of anhydrous DCM, Et3N (1.0 mL, 6.71 mmol) was added at room temperature under N2 atmosphere. After 12 hr at room temperature, the reaction mixture was poured into ice water (20 mL). The product was extracted with CH2Cl2 (20 mL x 3) from aqueous layer. The combined solution washed with saturated aqueous NH4Cl (10 mL x 2), water (20 mL) and brine (10 mL x 2) and then dried over Na2SO4, filtered, concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane: EtOAc = 20: 1 to 4: 1 v/v) to give compound (+)-12a (2.21 g, 4.94 mmol) in 92 % yield. [alpha]22D +30.57 (c 0.57, CHCl3).

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.
[2]Patent: WO2007/47793,2007,A2 .Location in patent: Page/Page column 50.

9
[ 124-63-0 ]
[ 163226-45-7 ]
[ 925672-01-1 ]

Yield	Reaction Conditions	Operation in experiment
92%	With triethylamine; In dichloromethane; at 0℃; for 1h;	On the basis of the Mitsunobu reaction of 5 with 7 or 15a-b, the condensation reaction of 5 with imidazol derivative (19) or a protected 3-deazaguanine (23) was initially investigated with the Mitsunobu reaction in order to synthesize carbocyclic 3-deazaguanosine (4). The coupling reaction of 5 with 19, which was prepared from 18 by following the previously reported method,16 provided N7-isomer (20) in 91% yield using the condition OfPh3P and DIAD in THF. The precursor 20 was subsequently converted to carbocyclic N7-3- deazaguanosine (21) in 56% yield (2 steps) by using methamolic ammonia and hydrogen chloride. The structure of 21 was determined by H- and C-NMR, as well as UV data (lambdamax 261 and 317 nm, pH 7.0), which was compared with previously reported data for N7-3- deazaguanosine (3).16b Furthermore, the Mitsunobu reaction of 5 with a protected 3- deazaguanine (23), which was synthesized from 19 by using cyclization with ammonia in a steel bomb and protection with isobutanoic anhydride, afforded a mixture of N9/N7-isomer (ratio 1 : 1) in 20% yield along with several by-products. Therefore, we investigated a more efficient condensation reaction in order to enhance the amount of Ncrisomer and reaction yield. The hydroxy group of 5 was transformed to a methansufonyl (Ms) group with MsCl in 92% yield.10 The substitution reaction of 22 with 23 in the presence of NaH and DMF solution gave Ncrisomer (24) in 40% yield along with 5% of N7-isomer (25), which could easily be removed from 24 by using silica gel column chromatography. The structure of 24 was determined with 1-D NOE and 1H- and 13C-NMR, as well as UV data ((lambdamax 271 and 300 nm, pH 7.0). AU data was consistent with 3-deazaguanosin (3) from previously reported literatures.1613 The significant interaction between the C1 '-H and aromatic C3-H of 24 was observed in NOE experiment as shown in figure 2. Subsequently, the compound 24 was treated with methalolic ammonia, followed by aqueous 0.1 M HCl solution to afford carbocyclic 3-deazaguanosine (C-3-DG, 4) in an 11% yield from imidazole derivative (19). In the case of the synthesis of C-3-DG (4), this simple substitution reaction was a more convenient strategy than the Mitsunobu reaction both by regioselectivity (Ng) and overall yield.

References: [1]Bioorganic and Medicinal Chemistry,2007,vol. 15,p. 839 - 846.
[2]Patent: WO2007/47793,2007,A2 .Location in patent: Page/Page column 39-40.
[3]Journal of Heterocyclic Chemistry,2015,vol. 52,p. 1132 - 1135.
[4]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.

10
[ 163226-45-7 ]
(3aS,4R,6aR)-2,2-dimethyl-6-((trityloxy)methyl)-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-ol [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.
[2]Bioorganic and Medicinal Chemistry Letters,2016,vol. 26,p. 3945 - 3949.

11
[ 163226-45-7 ]
[ 4928-88-5 ]
[ 878479-16-4 ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.

12
[ 163226-45-7 ]
[ 309947-86-2 ]
(1R,4R,5S)-9-N-[3-(trityloxymethyl)-4,5-O,O-isopropylidene-2-cyclopenten-L-yl]N₆,N₆-bis-(tert-butoxycarbonyl)adenine [ No CAS ]

References: [1]Tetrahedron Letters,2006,vol. 47,p. 9187 - 9189.

13
[ 163226-45-7 ]
5-[(1S,2R,3R)-2,3-dihydroxy-4-hydroxymethyl-4-cyclopenten-1-yl]uracil [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2007,vol. 15,p. 839 - 846.

14
[ 163226-45-7 ]
[ 925672-11-3 ]

References: [1]Bioorganic and Medicinal Chemistry,2007,vol. 15,p. 839 - 846.

15
[ 163226-45-7 ]
2-(2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl)-3-hydroxy-propionitrile [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2007,vol. 15,p. 839 - 846.

16
[ 163226-45-7 ]
[ 925672-02-2 ]

References: [1]Bioorganic and Medicinal Chemistry,2007,vol. 15,p. 839 - 846.

17
[ 163226-45-7 ]
[ 925672-13-5 ]

References: [1]Bioorganic and Medicinal Chemistry,2007,vol. 15,p. 839 - 846.

18
[ 163226-45-7 ]
3-(cyanomethyl-amino)-2-(2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl)-acrylonitrile [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2007,vol. 15,p. 839 - 846.

19
[ 163226-45-7 ]
[ 925672-14-6 ]

References: [1]Bioorganic and Medicinal Chemistry,2007,vol. 15,p. 839 - 846.

20
[ 163226-45-7 ]
[ 925672-10-2 ]

References: [1]Bioorganic and Medicinal Chemistry,2007,vol. 15,p. 839 - 846.

21
[ 163226-45-7 ]
[ 925672-12-4 ]

References: [1]Bioorganic and Medicinal Chemistry,2007,vol. 15,p. 839 - 846.

22
[ 163226-45-7 ]
5-[(1S,2R,3R)-2,3-dihydroxy-4-hydroxymethyl-4-cyclopenten-1-yl]isocytosine hydrochloride [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2007,vol. 15,p. 839 - 846.

23
[ 163226-45-7 ]
[2-cyano-2-(2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl)-vinylamino]-acetic acid ethyl ester [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2007,vol. 15,p. 839 - 846.

24
[ 163226-45-7 ]
ethyl 2,2-bis[(1S,2R,3R)-2,3-(isopropylidenedioxy)-4-(trityloxymethyl)-4-cyclopenten-1-yl]-2-cyanoacetate [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2007,vol. 15,p. 839 - 846.

25
[ 163226-45-7 ]
neplanocin A [ No CAS ]

References: [1]Tetrahedron Letters,2006,vol. 47,p. 9187 - 9189.

26
[ 934816-38-3 ]
[ 163226-45-7 ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.

27
[ 934816-31-6 ]
[ 163226-45-7 ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.

28
[ 934816-30-5 ]
[ 163226-45-7 ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.

29
[ 934816-35-0 ]
[ 163226-45-7 ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.

30
[ 934816-36-1 ]
[ 163226-45-7 ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.

31
[ 934816-32-7 ]
[ 163226-45-7 ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.

32
[ 934816-37-2 ]
[ 163226-45-7 ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.

33
[ 54503-64-9 ]
[ 163226-45-7 ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.
[2]Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,p. 7742 - 7747.

34
[ 54187-70-1 ]
[ 163226-45-7 ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.

35
[ 96690-02-7 ]
[ 163226-45-7 ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.

36
[ 163226-45-7 ]
1-(4,5-dihydroxy-3-hydroxymethylcyclopenten-2-enyl)-1H-1,2,3-triazole-4-carboxylic acid amide [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.

37
[ 163226-45-7 ]
1-(4,5-dihydroxy-3-hydroxymethylcyclopent-2-enyl)-1H-1,2,4-triazole-3-carboxylic acid amide [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.

38
[ 163226-45-7 ]
[ 878479-15-3 ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.

39
[ 163226-45-7 ]
[ 878479-20-0 ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.

40
[ 163226-45-7 ]
[ 878479-18-6 ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.

41
[ 163226-45-7 ]
[ 878479-21-1 ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.

42
[ 163226-45-7 ]
[ 878479-19-7 ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.

43
[ 163226-45-7 ]
1-(4,5-dihydroxy-3-hydroxymethylcyclopent-2-enyl)-1H-imidazole-4-carboxylic acid amide hydrochloride [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.

44
[ 934816-34-9 ]
[ 163226-45-7 ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1140 - 1148.

45
((3aR,4R,6R,6aS)-6-Hydroxy-2,2-dimethyl-4-trityloxymethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl)-trimethyl-ammonium; hydroxide [ No CAS ]
[ 163226-45-7 ]

References: [1]Journal of Organic Chemistry,2005,vol. 70,p. 6884 - 6890.

46
[ 163226-45-7 ]
[ 72877-50-0 ]

References: [1]Journal of Organic Chemistry,2005,vol. 70,p. 6884 - 6890.
[2]Journal of Medicinal Chemistry,2015,vol. 58,p. 5108 - 5120.

47
[ 163226-45-7 ]
[ 126261-36-7 ]

References: [1]Journal of Medicinal Chemistry,1993,vol. 36,p. 1210 - 1220.

48
[ 163226-45-7 ]
Benzoic acid (3aS,4S,6aR)-6-bromomethyl-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl ester [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1993,vol. 36,p. 1210 - 1220.

49
[ 163226-45-7 ]
(2S,5S,6S,6aR)-6-(tert-Butyl-dimethyl-silanyloxy)-2-ethoxycarbonylmethyl-5-hydroxy-3,5,6,6a-tetrahydro-2H-cyclopenta[b]furan-2-carboxylic acid ethyl ester [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1993,vol. 36,p. 1210 - 1220.

50
[ 163226-45-7 ]
(E)-2-((3S,4R,5R)-3-Benzoyloxy-4,5-dihydroxy-cyclopent-1-enylmethyl)-but-2-enedioic acid diethyl ester [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1993,vol. 36,p. 1210 - 1220.

51
[ 163226-45-7 ]
(E)-2-((3aR,6S,6aS)-6-Benzoyloxy-2,2-dimethyl-6,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-ylmethyl)-but-2-enedioic acid diethyl ester [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1993,vol. 36,p. 1210 - 1220.

52
[ 163226-45-7 ]
2'β-carboxy-5'β-(9-guanidino)-6'α-hydroxy-3',5',6',6'aβ-tetrahydro-2H-cyclopentafuran-2'α-acetic acid [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1993,vol. 36,p. 1210 - 1220.

53
[ 163226-45-7 ]
[ 148145-70-4 ]

References: [1]Journal of Medicinal Chemistry,1993,vol. 36,p. 1210 - 1220.

54
[ 163226-45-7 ]
(2S,5S,6S,6aR)-5-Benzoyloxy-6-(tert-butyl-dimethyl-silanyloxy)-2-ethoxycarbonylmethyl-3,5,6,6a-tetrahydro-2H-cyclopenta[b]furan-2-carboxylic acid ethyl ester [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1993,vol. 36,p. 1210 - 1220.

Historical Records

Technical Information

• Appel Reaction • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chugaev Reaction • Corey-Kim Oxidation • Dess-Martin Oxidation • Halogenation • Heat of Combustion • Hydride Reductions • Jones Oxidation • Martin's Sulfurane Dehydrating Reagent • Mitsunobu Reaction • Moffatt Oxidation • Nomenclature of Ethers • Oxidation of Alcohols by DMSO • Preparation of Alcohols • Preparation of Amines • Preparation of Ethers • Reactions of Alcohols • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Ethers • Reactions with Organometallic Reagents • Ritter Reaction • Sharpless Olefin Synthesis • Swern Oxidation

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P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 163226-45-7

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CAS No.: 163226-45-7

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[ 163226-45-7 ] Synthesis Path-Downstream 1~54

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