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Chemical Structure| 166815-97-0 Chemical Structure| 166815-97-0

Structure of 166815-97-0

Chemical Structure| 166815-97-0

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Product Details of [ 166815-97-0 ]

CAS No. :166815-97-0
Formula : C18H31NO6
M.W : 357.44
SMILES Code : O=C(OCC)C(CC1CCN(C(OC(C)(C)C)=O)CC1)C(OCC)=O

Safety of [ 166815-97-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 166815-97-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 166815-97-0 ]

[ 166815-97-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 166815-97-0 ]
  • 1-(tert-butoxycarbonyl)-4-[2,2-di(carboxy)ethyl]piperidine [ No CAS ]
  • [ 154775-43-6 ]
YieldReaction ConditionsOperation in experiment
With potassium hydroxide; In tetrahydrofuran; ethanol; water; Step (c) 1-(tert-Butoxycarbonyl)-4-[2,2-di(ethoxycarbonyl)ethyl]piperidine (12.2 g, 34 mmol), prepared as in Example 1, Step (b), and potassium hydroxide (4.2 g, 75 mmol) were combined in ethanol (10 mL), THF (20 mL), and water (50 mL) and the mixture was heated at reflux for 3 hours. The mixture was cooled and washed with ether, acidified with sulfuric acid, and extracted into ether. The ether was dried over sodium sulfate and evaporated. Crystallization of the residue from ether gave 1-(tert-butoxycarbonyl)-4-[2,2-di(carboxy)ethyl]piperidine (8.5 g, 28 mmol) which was heated in an oil bath to 165 C. until evolution of CO2 ceased (approximately 10 minutes). The residue was cooled and upon crystallization gave 3-[l-(tert-butoxycarbonyl)piperidin-4-yl]propionic acid (7.2 g, 28 mmol), m.p. 81-83 C.
 

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