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[ CAS No. 167883-99-0 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
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Chemical Structure| 167883-99-0
Chemical Structure| 167883-99-0
Structure of 167883-99-0 * Storage: {[proInfo.prStorage]}
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Product Details of [ 167883-99-0 ]

CAS No. :167883-99-0 MDL No. :MFCD13177281
Formula : C8H7ClN2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :166.61 Pubchem ID :-
Synonyms :

Safety of [ 167883-99-0 ]

Signal Word:Danger Class:8
Precautionary Statements:P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P403+P233-P501 UN#:3261
Hazard Statements:H302-H314 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 167883-99-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 167883-99-0 ]

[ 167883-99-0 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 35431-26-6 ]
  • [ 167883-99-0 ]
  • 5-(imidazo[1,2-a]pyridin-8-ylmethoxy)-2-methoxybenzaldehyde [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In N,N-dimethyl-formamide; at 125℃; for 0.25h;Microwave irradiation; Inert atmosphere; [0173] A mixture of <strong>[35431-26-6]5-hydroxy-2-methoxybenzaldehyde</strong> (723.6 mg, 4.7 mmol), 8- (chloromethyl)-imidazol[l,2-a] pyridine (785 mg, 4.7 mmol), and K2C03 (1.9 g, 14.1 mmol) in DMF (20 mL) was heated at microwave reactor at 125 C for 15 min. The mixture was filtered and concentrated. The residue was purified on silica gel (50-100% EtOAc in hexanes) to give 5-(imidazo[l,2-a]pyridin-8-ylmethoxy)-2-methoxybenzaldehyde.
  • 2
  • [ 133427-07-3 ]
  • [ 167883-99-0 ]
  • 3
  • [ 167883-99-0 ]
  • [ 10128-72-0 ]
  • C15H13N3O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In N,N-dimethyl-formamide; at 80 - 90℃; for 5h; [0163] To a DMF (15 mL) solution of the chloride (300 mg, 1.5 mmol, 1.0 eq) and phenol (230 mg, 1.5 mmol, 1.0 eq) was added K2C03 (621 mg, 4.5 mmol, 3.0 eq) and the reaction mixture was heated at 80-90 C for 5 h. Solvent was removed and the residue was purified by column chromatography (EtOAc/ MeOH) to give the alkylation product. MS: exact mass calculated for C15H13N303, 283.10; mlz found, 284 [M+H]+.
With potassium carbonate; In N,N-dimethyl-formamide; at 80 - 90℃; for 5h; To a DMF (15 mE) solution of the chloride (300 mg,1.5 mmol, 1.0 eq) and phenol (230 mg, 1.5 mmol, 1.0 eq) was added K2C03 (621 mg, 4.5 mmol, 3.0 eq) and the reaction mixture was heated at 80-90 C. for 5 h. Solvent was removed and the residue was purified by column chromatography (EtOAc/MeOH) to give the alkylation product. MS: exact mass calculated for C15H13N303, 283.10; mlz found, 284 [M+H].
  • 4
  • [ 867267-28-5 ]
  • [ 167883-99-0 ]
  • 5-(imidazo[1,2-a]pyridin-8-ylmethoxy)-2-methoxyisonicotinaldehyde [ No CAS ]
YieldReaction ConditionsOperation in experiment
38% With potassium carbonate; In N,N-dimethyl-formamide; at 125℃; for 0.25h;Microwave irradiation; [0173] A mixture of <strong>[867267-28-5]5-hydroxy-2-methoxyisonicotinaldehyde</strong> (723.6 mg, 4.7 mmol), 8- (chloromethyl)-imidazol{1,2-a] pyridine (785 mg, 4.7 mmol), and K2C03 (1.9 g, 14.1 mmol) in DMF (20 mL) was heated at microwave reactor at 125 C for 15 mm. The mixture was filteredand concentrated. The residue was purified on silica gel (50-100% EtOAc in hexanes) to give 5- (imidazo[l,2-a]pyridin-8-ylmethoxy)-2-methoxyisonicotinaldehyde (500 mg, 38%) as an off- white solid. 1H NMR (400 MHz; DMSO) = 10.37 (s, 1 H), 8.58 (d, 1 H), 8.39 (s, 1 H), 8.02 (s, 1 H), 7.61 (s, 1 H), 7.44 (d, 1 H), 6.98 (s, 1 H), 6.93 (t, 1 H), 5.61 (s, 2 H), 3.84 (s, 3 H). LRMS (M+H+) m/z 284.0.
38% With potassium carbonate; In N,N-dimethyl-formamide; at 125℃; for 0.25h; Step 4 ;A mixture of <strong>[867267-28-5]5-hydroxy-2-methoxyisonicotinaldehyde</strong> (723.6 mg, 4.7 mmol), 8-(chloromethyl)-imidazol[1,2-a]pyridine (785 mg, 4.7 mmol), and K2CO3 (1.9 g, 14.1 mmol) in DMF (20 mL) was heated at microwave reactor at 125 C. for 15 min. The mixture was filtered and concentrated. The residue was purified on silica gel (50-100% EtOAc in hexanes) to give 5-(imidazo[1,2-a]pyridin-8-ylmethoxy)-2-methoxyisonicotinaldehyde (500 mg, 38%) as an off-white solid. 1H NMR (400 MHz; DMSO) 6=10.37 (s, 1H), 8.58 (d, 1H), 8.39 (s, 1H), 8.02 (s, 1H), 7.61 (s, 1H), 7.44 (d, 1H), 6.98 (s, 1H), 6.93 (t, 1H), 5.61 (s, 2H), 3.84 (s, 3H). LRMS (M+H+) m/z 284.0.
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