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Chemical Structure| 168986-49-0 Chemical Structure| 168986-49-0

Structure of 168986-49-0

Chemical Structure| 168986-49-0

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Product Details of [ 168986-49-0 ]

CAS No. :168986-49-0
Formula : C8H15NO2
M.W : 157.21
SMILES Code : O=C(OC)CC1CCNCC1
MDL No. :MFCD04115353

Safety of [ 168986-49-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

Application In Synthesis of [ 168986-49-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 168986-49-0 ]

[ 168986-49-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 661463-17-8 ]
  • [ 168986-49-0 ]
  • methyl 2-(1-(6-fluoroquinolin-4-yl)piperidin-4-yl)acetate [ No CAS ]
  • 2
  • [ 1480-65-5 ]
  • [ 168986-49-0 ]
  • methyl 2-[1-(5-chloropyridin-2-yl)piperidin-4-yl]acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
69% With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 90℃; for 16h;Inert atmosphere; A solution of <strong>[1480-65-5]5-chloro-2-fluoropyridine</strong> (500 mg, 3.80 mmol), DIEA (1.5 g, 11.61 mmol), methyl 2-(piperidin-4-yl)acetate (599 mg, 3.81 mmol) in DMSO (10 mL) was stirred for 16 h at 90 °C under N2. The resulting solution was extracted with 2x50 mL of EtOAc, and the combined organic layers were concentrated under vacuum and purified with silica gel chromatography using EtOAc / hexane (1/1) to afford 700 mg (69percent) of the title compound as an off-white solid. -MS (ES, m/z): 268.9
 

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[ 168986-49-0 ]

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