Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 171489-59-1 | MDL No. : | MFCD04973633 |
Formula : | C22H19ClN2O5 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | JUKHNCNDFOAFLT-IIBYNOLFSA-N |
M.W : | 426.85 | Pubchem ID : | 10873617 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P280-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H317-H319 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95.3% | In methanol; for 3h;Reflux; Large scale; | Add Intermediate 3 (20kg, 47mol), 30% methylamine methanol solution (25kg, 235mol), 140L of methanol was added to the reactor, Heat and stir to reflux, keep the reaction for 3h, After the reaction was detected by HPLC, it was cooled down to room temperature, centrifuged and washed with a small amount of methanol. The product was dried to obtain 17.3 kg of a white solid with a yield of 95.3% and a purity of 99.3%. |
93.7% | In water; dimethyl sulfoxide; at 20 - 30℃; | (1) 300 g (0.703 mol) of Compound A (HPLC purity: 98.5%)And 750 ml of dimethyl sulfoxide was added to the reaction flask to stir and dissolve.Add 191.1 g (2.460 mol) of 40% aqueous solution of methylamine, continue stirring at 20-30 C for 2-3 h.After the reaction of Compound A, 1800 ml of pure water was added dropwise, and the mixture was precipitated; suction filtration, the filter cake was added with 120 ml of ethanol, and dried, and dried at 75 C under reduced pressure.281.1 g of white powdered tadalafil crude solid,The yield is 93.7%. HPLC: 99.92%,The maximum single impurity is 0.05%;The HPLC method is a USP related material method. |
92.8% | In tetrahydrofuran; water; at 25 - 45℃; for 1.5h; | Tadalafei preparation: the resulting (1R, 3R) - 1, 2, 3, 4-tetrahydro-2-acetyl-1 - (3,4-methylene-dioxy phenyl) - 9H-pyrido [3,4-b] indole-3-carboxylic acid methyl ester crystal 35.0g soluble in 210mLTHF in, temperature control in 25-30C, after dissolving to be slow, the 28.1g40% methylamine aqueous solution is dripped slowly into the, heating to the completion of the dropping 40-45 C reaction 1.5h, after the reaction, the reaction liquid is added to 140 ml of water, then adding concentrated hydrochloric acid to adjust pH to 2, then the system turns on lathe does THF, by adding 280 ml isopropanol, 20 C stirring under 2h, filtering, washing with isopropyl alcohol, for 60 C the lower vacuum drying 7h, to obtain white solid 29.6g, purity: 99.99% (Tadalafei isomer impurity content is 0.01%), yield: 92.8%. |
90% | In methanol; water; at 35 - 55℃; for 5h; | Cis-l-benzo[l,3]dioxol-5-yl-2-(2-chloro-acetyl)-2,3,4,9-tetrahydro-lH-beta- carboline- 3 -carboxylic acid methyl ester (30 g) was taken in methanol (450 ml). The resultant mixture was heated to 35?40 C and aqueous methyl amine (27 ml; 40%) was added. The reaction mixture was stirred at 50-55 C for 5 hours and then cooled to 10- 15 C with continuous stirring for 0.5 hours. The solid so obtained was filtered and dried to afford (6R,12aR) 6-(l,34>enzodioxol-5-yl)-2,3AV V2a-hexahydro-2-methylrhoyrazino [rf2':l,6] pyrido[3,4-b]indole-l,4-dione.Yield: 24.6 g (90%) Purity: 99.9% (by HPLC) |
90% | In methanol; at 45 - 55℃; | Compound V (39 g, 0.09 mol),700 ml of methanol, a solution of methylamine (64 ml, 0.43 mol),mixing,Stirring temperature,The reaction was stirred at 45 ~ 55 for 8 ~ 11 hours,Cool to room temperature, filter, water,Methanol and dried to give 32.0 g (90.0%) crude tadalafil. Tadalafil crude 30g, adding acetone 900ml, methanol 210ml, stirring heated to dissolve, incubated for 0.5 hours, filtered and dried to give tadalafil 20g, yield 66.7%, HPLC purity of 99.7%, a single Impurity content <0.1%, ee value 99.5%. |
88% | In methanol; at 50℃; for 10h;Product distribution / selectivity; | A solution of methylamine (33. % in methanol) (148 mL) was added at room temperature to a stirred suspension of, (lR, 3R)-metllyl-1, 2,3, 4-tetrahydro- 2-chloroacetyl- (3,4- methylenedioxyphenyl)-9H-pyrido- [3, 4b] indole 3-carboxylate (II) (168 g) in methanol (2.52 L) and the resulting mixture was heated at 50 C for 10 hrs. The reaction was monitored by TLC. The reaction mixture was cooled, the solids filtered, washed with methanol, dried in a vacuum oven to obtain Tadalafil (I) in the form of a crystalline fluffy powder (135 g). (Yield : 88 %; Purity by HPLC: 99.97 %; m. p.: 290-292 C (dec.) ; Bulk density=0. 25-0.3 g/cc). |
84% | In methanol; water; at 50℃;Product distribution / selectivity; | An aqueous solution of methylamine was added at room temperature to a stirred suspension of (lR, 3R)-methyl-l, 2,3, 4-tetrahydro-2-chloroacetyl- (3, 4-methylenedioxyphenyl)-9H-pyrido- [3,4b] indole 3-carboxylate (II) (25 g) in methanol (375 mL) and the resulting mixture was heated at 50 OC. The reaction was monitored by TLC and upon completion was cooled, the solids filtered, washed with methanol and dried in a vacuum oven to obtain Tadalafil (I) in the form of crystalline fluffy powder (Yield: 84 % ;, Purity by HPLC : 99.9 %; m. p.: 290 0 C (dec.)). |
77% | In tetrahydrofuran; water; at 55℃; for 1h;Inert atmosphere; | 0.5 g of carboline chloroacetyl 5cis were dissolved in 2.5 ml of THF. 0.45 g of a 40% methylamine solution in water were added dropwise at 25C and under a N2 atmosphere. It was heated to 55C stirred for 1 h. It was cooled to 0-5C and 3 ml of a 2: 1 IPA/water mixture were added. Concentrated HCI was added until reaching an acid pH. The THF was distilled, cooled to 0-5C and 1 .5 ml of IPA and 0.5 ml of water were added. It was stirred at 0-5C for 2 h. It was filtered and the solid obtained washed with a cold 1 : 1 mixture ofIPA/water and dried under vacuum at 50C. This produced 0.35 g of 7 (77% yield). HPLC Purity: 99.6%. Melting point 293C. 1 H NMR (400 MHz, DMSO) delta 1 1.03 (s, 1 H), 7.55 (d, J = 7.7 Hz, 1 H), 7.31 (d, J = 7.9 Hz, 1 H), 7.06 (t, J = 7.3 Hz, 1 H), 7.00 (t, J = 7.3 Hz, 1 H), 6.88 (s, 1 H), 6.83 - 6.73 (m, 2H), 6.15 (s, 1 H), 5.92 (s, 2H), 4.40 (dd, J = 1 1.5, 3.8 Hz, 1 H), 4.18 (d, J = 17.1 Hz, 1 H), 3.94 (d, J = 17.2 Hz, 1 H), 3.53 (dd, J = 15.8, 4.3 Hz, 1 H), 3.04 - 2.95 (m, 1 H), 2.93 (s, 3H). IR (KBr) vmax 3328, 3061, 2905, 2776, 1678, 1627, 1438, 1323, 1243, 1041, 749 cm"1. |
77% | In tetrahydrofuran; water; at 55℃; for 1h;Inert atmosphere; | 0.5 g of carboline chloroacetyl 5cis were dissolved in 2.5 ml of THF. 0.45 g of a 40% methylamine solution in water were added dropwise at 25 C. and under a N2 at mosphere. It was heated to 55 C. stirred for 1 h. It was cooled to 0-5 C. and 3 ml of a 2:1 IPA/water mixture were added. Concentrated HCl was added until reaching an acid pH. The THF was distilled, cooled to 0-5 C. and 1.5ml of iPA and 0.5ml of water were added. It was stirred at 0-5 C. for 2 h. It was filtered and the solid obtained washed with a cold 1: mixture of iPA/water and dried under vacuum at 50 C. This produced 0.35 g of 7 (77% yield). HPLC Purity: 99 .6%. Melting point 293 C. 1HNMR (400MHz, DMSO) 611.03 (s, 1H), 7.55 (d,Hz, 1H), 7.31 (d,j=7.9 Hz, 1H), 7.06 (t, j=7.3 Hz, 1H),7.00 (t, j=7.3 Hz, 1H), 6.88 (s, 1H), 6.83-6.73 (m, 2H), 6.15 (s, 1H), 5.92 (s. 2H), 4.40 (dd, 3.8 1H), 4.18 (d, j=17.1 Hz, 1H), 3.94 (d, j=17.2 Hz, 1H), 3.53 (dd, j=15.8, 4.3Hz, 1H), 3.04-2.95 (m, 1H), 2.93 (s, 3H). IR (KBr) vmax 3328, 3061, 2905, 2776, 1678, 1627, 1438, 1323, 1243, 1041, 749 cm- 1? |
66% | In methanol; ethanol; at 50℃; for 7h;Product distribution / selectivity; | A solution of methylamine in ethanol (0.44 mL) was added at room temperature to a stirred suspension of (1R, 3R)-methyl-1, 2,3, 4-tetrahydro- 2-chloroacetyl- (3, 4-methylenedioxyprLenyl)- 9H-pyrido-[3, 4b] indole 3-carboxylate (II) (0.5 g) in methanol and the resulting mixture was heated at 50 OC for 7 hrs. The reaction was monitored by TLC. The solids were filtered, washed with methanol and dried in a vacuum oven to obtain Tadalafil (I) as crystalline fluffy powder (0.33g) (Yield :- 66 % ; Purity by HPLC :- 99. 8 % ; m. p.: 290-292C (dec. )). |
With methanol; at 25 - 55℃; for 7h; | Example: Preparation of Tadalafil; Methyl amine solution (25% in methanol, 163 ml) is added to a suspension of (6R,12aR) - Methyl 1,2,3,4 -tetrahydro-2 - chloroacetyl-1-(3,4 -methylenedioxy phenyl)-9H- pyrido [3,4-b]indole-3-carboxylate (Chloro acetyl intermediate) (79 g) in methanol (790 ml). Temperature of the reaction mass is raised and maintained at 50C to 55C for 6 hrs. The reaction mass is then cooled and maintained at 25C to 30C for 1 hr, filtered, washed with methanol (50 ml) and dried at 45C to 50C. Dry wt of the crude Tadalafil is 67 g (92.5 % yield) Crude Tadalafil (67 g) is dissolved in DMF (330 ml, ) at room temperature, treated with activated carbon for 30 min at 25C to 30C. The reaction mass is filtered and the filtered mass is quenched into methanol (2010 ml) over lhr at 25C to 30C under mixing. The reaction mass is cooled and maintained at 0C to 5C for 2hrs. The precipitated product is filtered, washed with methanol (50 ml) and dried at 50C to 55C. Dry wt of the pure Tadalafil is: 50 g (74.6 % yield) | |
With sodium hydrogencarbonate; In propan-1-ol; water; at 55 - 60℃; for 4 - 10h; | Example-2; Preparation of Tadalafli To a cooled suspension of (1R,3R)-Methyl-1,2,3,4-tetrahydro-1-(3,4-methylenedioxy phenyl)-9H-pyrido[3,4-b]indole-3-carboxylate (100 g) and Sodium bicarbonate (30 g) in Dichloromethane (2000 ml) at 0 C., Chloroacetylchloride (57 ml) was added maintaining temperature between 0 and 5 C. The reaction mixture was stirred at 0-5 C. for 1-3 hrs. The progress of the reaction was monitored on TLC. After completion of reaction, the reaction mixture was diluted with dichloromethane (2000 ml), washed with Sodium bicarbonate and then by water. Dichloromethane was evaporated from organic phase and n-Propanol (1500 ml) was charged to the residue. Aqueous Methylamine solution (40% in water) (111 ml) was added to the above reaction mixture and heated to 55-60 C. for 4-10 hours. The progress of the reaction was monitored on TLC. After completion of reaction, the mixture was cooled at 25-35 C. The solid was filtered and washed the wet cake with methanol (2×50 ml). The solid was recrystallized from 2-propanol to give title compound (85 g). Mp: 302-303 C. [alpha]D20=+71.0(c=1.00,CHCl3) | |
In propan-1-ol; water; at 55 - 60℃; for 4 - 10h; | ExampIe-2 Preparation of Tadalafil To a cooled suspension of (lR,3R)-Methyl-l,2,3,4-tetrahydro-l-(3,4-methylenedioxy phenyl)-9H-pyrido[3,4:b]indoe-3-carboxylate (10Og) and Sodium bicarbonate (3Og) in Dichloromethane (2000ml) at 0C, Chloroacetylchloride (57ml) was added maintaining temperature between 0 and 5C. The reaction mixture was stirred at 0-5C for 1-3 hrs. The progress of the reaction was monitored on TLC. After completion of reaction, the reaction mixture was diluted with dichloromethane (2000 ml), washed with Sodium bicarbonate and then by water. Dichloromethane was evaporated from organic phase and n-Propanol (1500ml) was charged to the residue. Aqueous Methylamine solution (40% in water) (111ml) was added to the above reaction mixture and heated to 55-6OC for 4-10 hours. The progress of the reaction was monitored on TLC. After completion of reaction, <n="13"/>the mixture was cooled at 25-35C. The solid was filtered and washed the wet cake with methanol (2x5 OmI). The solid was recrystallized from 2-propanol to give title compound (85g).Mp: 302-303C. [ alpha]D20 = + 71.0 (C=1.00CHC13) | |
In methanol; water; at 0 - 50℃;Inert atmosphere of nitrogen; | Example 11 Preparation of (6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxy phenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione) Methyl (6R,12aR)-1,2,3,4-tetrahydro-2-chloroacetyl-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate (2.5 g), prepared by Example 10 was suspended in methanol (37.5 ml) at room temperature. A solution of methylamine (40 % in water) (1.5 ml) was added and the flask was purged with nitrogen. The mixture was heated to 50 C and stirred at 50 C for 6 hours. The mixture was cooled to 0 C and stirred at 0 C for 1 hour. The product was filtered off, washed with methanol and dried to give 2.1 g of product. | |
In methanol; at 25 - 60℃;Product distribution / selectivity; | Examples Example 1; To a stirred suspension of (6R,12aR)-methyl-1,2,3,4-tertahydro-2-chloro acetyl-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate (5 gm) in methanol (75 ml) was added methanolic methylamine (7.4 ml, 26% methylamine in methanol by weight/volume) at 25 - 30ºC, the reaction mass was heated to 50 - 60 . C and maintained at this temperature for 3 hours. The reaction mass was monitored by HPLC for the completion of the reaction. After the reaction was completed, the reaction mass was cooled to 25 - 30ºC and <n="7"/>stirred at this temperature for one hour. Filtered the material and washed the solid obtained with methanol and dried to get pure tadalafil [Yield: 4.3 gm; HPLC purity 99.98%]. | |
In water; isopropyl alcohol; at 110 - 120℃; | Intermediate B (4g) obtained in Example 1 and 40% aqueous methylamine solution (1.6mL) were dissolved in 70% aqueous solution of 2-propanol (120mL) while heating in a closed reaction vessel above the reflux temperature (110-120C) for two to five hours. The solution was hot filtered and cooled on an ice bath. The precipitated product was filtered and dried. The purity of the product was 99.9% (HPLC area%) and the particle distribution of the product was D(90) of about 144 microns. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
66% | N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; at 45℃; for 24h; | PREPARATION OF EXAMPLE 2 6R,12AR)-6-Benzo[1,3]dioxo-5-yl-2-hydroxy-2,3,6,7,12,12a-hexahydropyrazino1',2':1,6]-pyrido[3,4-b]indole-1,4-dione Intermediate 2 (3.45 g, 8.08 mmol) and hydroxylamine hydrochloride (1.12 g, 16.2 mmol) were suspended in tetrahydrofuran.While stirring, 3.5 ml water and then 2.82 ml (16.2 mmol) diisopropylethylamine were added to the mixture.The resulting mixture was heated at 45 C. in an oil bath for 24 hours.The reaction mixture was allowed to cool to room temperature, then was poured into-ethyl acetate, washed with saturated NaCl, dried over sodium sulfate (Na2SO4), filtered, and the solvent stripped on a rotary evaporator.The resulting residue was recrystallized from ethyl acetate to yield 2.09 g (66%) of Example 2 as an off-white solid: mp=276-283 C. (dec.); 1H NMR (DMSO-d6): delta 10.99 (s, 1H), 10.23 (s, 1H), 7.55 (d, J=7.4, 1H), 7.29 (d, J=7.8, 1H), 7.06 (t, J=7.3, 1H), 6.99 (t, J-7.5, 1H), 6.88 (s, 1H), 6.84-6.77 (m, 2H),-6.05 (s, 1H), 5.93 (d, J=2.3, 2H), 4.45 (d of d, J1=12.1, J2=4.0, 1H), 4.39 (d, J=19.9, 1H), 4.10 (d, J=16.4, 1H), 3.57 (d of d, J1=15.3, J2=1-0.9, 1H); MS m/z 332 (M+H), 414 (M+Na); [alpha]D27 C.=106.6 (c=0.05, DMSO); Anal. Calcd. for C21H17N3O5; C, 64.45; H, 4.38; N, 10.74. Found: C, 64.14; H, 4.55; N, 10.55.Stereochemistry was confirmed by NOE experiments: Positive NOE enhancements observed from C12a (4.39 ppm) to C6 (6.05 ppm) and from C6 to C12a. |
Tags: 171489-59-1 synthesis path| 171489-59-1 SDS| 171489-59-1 COA| 171489-59-1 purity| 171489-59-1 application| 171489-59-1 NMR| 171489-59-1 COA| 171489-59-1 structure
[ 449797-42-6 ]
1-(2-Chlorophenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
Similarity: 0.71
[ 107447-05-2 ]
(1S,3S)-Methyl 1-isobutyl-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
Similarity: 0.81
[ 16108-10-4 ]
Methyl 1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
Similarity: 0.78
[ 1910779-16-6 ]
1-(tert-Butoxycarbonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
Similarity: 0.74
[ 81075-61-8 ]
(R)-Methyl 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
Similarity: 0.74
[ 534557-15-8 ]
1-(3-Methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
Similarity: 0.81
[ 107447-05-2 ]
(1S,3S)-Methyl 1-isobutyl-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
Similarity: 0.81
[ 347860-69-9 ]
1-(3-Hydroxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
Similarity: 0.78
[ 16108-10-4 ]
Methyl 1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
Similarity: 0.78
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :