Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 17216-08-9 | MDL No. : | MFCD00001689 |
Formula : | C12H12O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | BSELJBOMYPMBNL-UHFFFAOYSA-N |
M.W : | 188.22 | Pubchem ID : | 86527 |
Synonyms : |
|
Signal Word: | Warning | Class: | |
Precautionary Statements: | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 | UN#: | |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
64% | With sodium hydride In 1,2-dimethoxyethane for 6h; Heating; | |
With sodium hydride In 1,2-dimethoxyethane for 6h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
63% | With sodium hydride In 1,2-dimethoxyethane for 6h; Heating; | |
With sodium hydride In 1,2-dimethoxyethane for 6h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
21% | With sodium hydride In 1,2-dimethoxyethane for 6h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1: 43% 2: 20% | With sodium hydride In 1,2-dimethoxyethane for 6h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
11%; 87% | With N-Bromosuccinimide; dibenzoyl peroxide; In benzene; for 4.0h;Reflux; Inert atmosphere; | General procedure: A benzene suspension (30 mL) of 1-tetralone 4, 11, 16 (1.0 equiv), N-bromosuccinimide (NBS) (2.2 equiv) and (PhCOO)2 (5 mol %) was refluxed under Argon atmosphere for 4 h and then cooled to 20 C. To the reaction mixture was added triethylamine (1 mL) and the solvent was removed in vacuo. The reaction mixture was diluted with water and extracted with CH2Cl2 (3×25 mL). The combined organic layers were dried (Na2SO4), filtered and the filtrate was concentrated in vacuo. The residue was purified by flash chromatography (silica gel, heptane/EtOAc) to give 5, 12 and 17. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
57.8% | <strong>[5978-75-6]9-aminofluorene hydrochloride</strong> (0.020 mol) in anhydrous ethanol (100 mL),triethylamine (0.020 mol) was added at room temperature during 2 h and standing for0.5 h. The supernatant was allowed to react with a solution of 2-acetyl-1-tetralone(0.020 mol) and 0.7 mL acetic acid in anhydrous ethanol (100 mL) at the refluxingtemperature for 24 h. After refluxing with stirring for 24 h, the resulting mixture wascooled to room temperature to afford a yellow solid. The solid was recrystallized fromcold ethanol to get ligand L4 as a yellow crystal in 57.8% yield. Mp: 202-203 C. 1HNMR (CDCl3), delta (ppm): 13.01 (s, 1H), 7.43-7.95 (m, 8H), 7.16-7.32 (m, 4H), 5.67 (s,1H), 2.35-2.65 (m, 4H), 1.64 (s, 3H,). 13C NMR(CDCl3, delta, ppm): 184.23, 162.64,144.58, 141.08, 140.15, 135.99, 130.65, 128.75, 127.82, 127.05, 126.50, 126.36, 124.67,120.27, 101.76, 59.21, 29.25, 24.92, 15.56. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | With tetrakis-(triphenylphosphine)-palladium; sodium hydride In tetrahydrofuran at 60℃; for 12h; Glovebox; Schlenk technique; Inert atmosphere; | |
98% | With triphenylphosphine; 1-n-butyl-3-methylimidazolium tetrafluoroborate; Palladium(0) bis(dibenzylideneacetone) In lithium hydroxide monohydrate at 80℃; Inert atmosphere; | Method B: General procedure: bis(dibenzylideneacetone)palladium(0)(5 mg, 8.7 Χ 10-3 mmol), 1 (10.2 mg, 0.022 mmol),triphenylphosphine (5.8 mg, 0.022 mmol), 1 mL of BMIM BF4 and 1 mL of water were added to a pressure tube. The mixture was stirred for 1 hour at room temperature to form the catalytic complex. Then,the allylic acetate (1 mmol) and the nucleophile(1 mmol) were added and the tube was set under inert atmosphere. The reaction mixture was stirred at 80 °C overnight. Next, the product was extracted from the IL-phase with tert-butyl methyl ether threetimes. Then, the organic portions were collected and washed with water three times. Finally, the crude was dried with MgSO4, filtered, evaporated and purified by column chromatography (flash-silica-gel) using mixtures of n-exane:AcOEt eluent. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
86% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In dimethyl sulfoxide at 60℃; Glovebox; Schlenk technique; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
73% | With sodium hydroxide; In ethanol; at 27℃; | General procedure: Twenty one alpha,beta-unsaturated carbonyl based compounds (1-7; 11-17; 21-27) were synthesized by direct coupling of the appropriate aromatic aldehyde with the ten different types of ketones at a molar ratio of 1:2, and the compounds (8-10; 18-20; 28-30) were synthesized at a molar ratio of 1:1 under base catalyzed Claisene-Schmidt condensation reaction conditions. Scheme 1 demonstrates the general synthesis of alpha,beta-unsaturated carbonyl based compounds d. Concisely, the appropriate aromatic aldehyde (20 mmol, 2 equivalent) and the suitable ketone (10 mmol, 1 equivalent) were mixed and dissolved in 15 ml of ethanol in single necked round bottomed flask, and stirred at 5 C for a couple of minutes. Afterwards, a 40% NaOH solution in ethanol was then added drop wise for several minutes. The mixture was left stirring at room temperature (27 C) for 1-24 h. The precipitate formation and color changes of the reaction mixture served as an indication of product formation. The reaction was monitored by TLC and upon completion; the reaction was quenched by the addition of acidified ice to the mixture. The alpha,beta-unsaturated carbonyl based compounds were isolated by column chromatography or by recrystallization. |
73% | With sodium hydroxide; In ethanol; at 5 - 27℃; | General procedure: Twenty one alpha,beta-unsaturated carbonyl based compounds (1-7; 11-17; 21-27) were synthesized by direct coupling of the appropriate aromatic aldehyde with the ten different types of ketones at a molar ratio of 1:2, and the compounds (8-10; 18-20; 28-30) were synthesized at a molar ratio of 1:1 under base catalyzed Claisen-Schmidt condensation reaction conditions. Scheme 1 demonstrates the general synthesis of alpha,beta-unsaturated carbonyl based compounds d. Concisely, the appropriate aromatic aldehyde (20 mmol, 2 equivalent) and the suitable ketone (10 mmol, 1 equivalent) were mixed and dissolved in 15 ml of ethanol in single necked round bottomed flask, and stirred at 5 C for a couple of minutes. Afterwards, a 40% NaOH solution in ethanol was then added drop wise for several minutes. The mixture was left stirring at room temperature (27 C) for 1-24 h. The precipitate formation and color changes of the reaction mixture served as an indication of product formation. The reaction was monitored by TLC and upon completion; the reaction was quenched by the addition of acidified ice to the mixture. The alpha,beta-unsaturated carbonyl based compounds were isolated by column chromatography or by recrystallization. |
With sodium hydroxide; In ethanol; at 5 - 27℃; | General procedure: Twenty one alpha,beta-unsaturated carbonyl based compounds (1-7;11-17; 21-27) were synthesized by coupling of suitable aromatic aldehyde with the 10 types of ketones at a molar ratio of 1:2,whereas nine (8-10; 18-20; 28-30) were synthesized at a ratio of1:1, under base catalyzed Claisen-Schmidt condensation reaction. Scheme 1 demonstrates the synthesis of a,b-unsaturated carbonyl based compounds. The appropriate aromatic aldehyde (20 mmol,2 equiv) and suitable ketone (10 mmol, 1 equiv) were mixed and dissolved in ethanol in a round bottomed flask and stirred at 5Cfor a few minutes. A 40% NaOH solution in ethanol was added dropwise into this solution and the resulting mixture was allowed to stir at room temperature (27C) for 1-24 h. The appearance of precipitate and color changes of the reaction mixture acted as indicative markers of product formation. The reaction was monitored by TLCand on completion; the reaction was stopped by adding acidified ice. The alpha,beta-unsaturated carbonyl based compounds were isolatedby either column chromatography or recrystallization. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
60% | With N,N,N-tributylbutan-1-aminium fluoride In acetonitrile at -20℃; for 2h; |
Tags: 17216-08-9 synthesis path| 17216-08-9 SDS| 17216-08-9 COA| 17216-08-9 purity| 17216-08-9 application| 17216-08-9 NMR| 17216-08-9 COA| 17216-08-9 structure
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :