* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
To 2000L is put in the reactor 270 kg P-toluenesulfonic acid monohydrate, toluene 550 kg, turning on the agitation, heating to reflux, with the water to drop the generated water, until there is no water generating, glycine is added in to the reaction solution 100 kg, benzalcohol 850 kg, to continue heating to reflux, water constantly by the generated water is separated, water until no, continue to reflux 2 hours, cooling to 10 °C, stirring 1 hour, filtering, with 100 kg of acetone washing the filter cake, drying to be 395 kg glycine benzyl ester P-toluenesulfonate, yield 88.4percent, purity 99.62percent.
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4-[(3R,4R,5S)-3-acetoxy-5-(tert-butyldiphenylsiloxy)methyl-4-(triethylsiloxy)pyrrolidin-2-ylidene]-2-[2-(Z)-(benzyloxymethoxy)methyl-1-propenyl]-4H-oxazol-5-one[ No CAS ]
4-[(3R,4R,5S)-3-acetoxy-5-(tert-butyldiphenylsiloxy)methyl-4-(triethylsiloxy)pyrrolidin-2-ylidene]-2-[2-(Z)-(benzyloxymethoxy)methyl-1-propenyl]-4H-oxazol-5-one[ No CAS ]