[ CAS No. 1753-75-9 ]

Name: 1753-75-9|5-Bromobenzo[c][1,2,5]thiadiazole|95%
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CAS No. :	1753-75-9	MDL No. :	MFCD00460091
Formula :	C₆H₃BrN₂S	Boiling Point :	272.2°C at 760 mmHg
Linear Structure Formula :	-	InChI Key :	N/A
M.W :	215.07 g/mol	Pubchem ID :	2776295
Synonyms :

Safety of [ 1753-75-9 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H319	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 1753-75-9 ]

Upstream synthesis route of [ 1753-75-9 ]
Downstream synthetic route of [ 1753-75-9 ]

[ 1753-75-9 ] Synthesis Path-Upstream 1~2

1
[ 1575-37-7 ]
[ 1753-75-9 ]

Yield	Reaction Conditions	Operation in experiment
86%	for 1 h; Heating / reflux	Example 2 Synthesis of 5-bromo-2,1,3-benzothiadiazole A mixture was prepared by mixing 4.0 g (21 mmol) of 4-bromo-o-phenylenediamine, 14 mL of thionyl chloride and 0.62 mL of concentrated sulfuric acid and was refluxed for one hour. This mixture was cooled and then poured onto ice, and a resulting precipitate was filtered and collected. This precipitate was washed with water till the waste water became neutral and then thoroughly dried to yield 4.5 g of 5-bromo-2,1,3-benzothiadiazole as a crude product (melting point, 48 to 50° C.; yield, 96.5percent).

Reference： [1] RSC Advances, 2016, vol. 6, # 71, p. 66978 - 66989
[2] Patent: US2009/149676, 2009, A1, . Location in patent: Page/Page column 5
[3] ChemMedChem, 2018, vol. 13, # 21, p. 2332 - 2348
[4] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1967, vol. 3, p. 662 - 666[5] Khimiya Geterotsiklicheskikh Soedinenii, 1967, vol. 3, # 5, p. 839 - 844
[6] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1979, vol. 17, p. 13 - 16
[7] Journal of Heterocyclic Chemistry, 1970, vol. 7, p. 629 - 633
[8] Patent: US2004/152738, 2004, A1,
[9] Chemistry - A European Journal, 2010, vol. 16, # 3, p. 899 - 906
[10] Chemistry--A European Journal, 2012, vol. 18, # 37, p. 11685 - 11694,10

2
[ 1753-75-9 ]
[ 72023-79-1 ]

Reference： [1] Zhurnal Obshchei Khimii, 1957, vol. 27, p. 2599,2603; engl. Ausg. S. 2656, 2659
[2] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1967, vol. 3, p. 662 - 666[3] Khimiya Geterotsiklicheskikh Soedinenii, 1967, vol. 3, # 5, p. 839 - 844
[4] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1979, vol. 17, p. 13 - 16

[ 1753-75-9 ] Synthesis Path-Downstream 1~25

1
[ 1753-75-9 ]
[ 72023-79-1 ]

Reference： [1]Zhurnal Obshchei Khimii,1957,vol. 27,p. 2599,2603; engl. Ausg. S. 2656, 2659
[2]Chemistry of Heterocyclic Compounds,1967,vol. 3,p. 662 - 666
Khimiya Geterotsiklicheskikh Soedinenii,1967,vol. 3,p. 839 - 844
[3]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1979,vol. 17,p. 13 - 16

2
[ 1575-37-7 ]
[ 1753-75-9 ]

Yield	Reaction Conditions	Operation in experiment
86%	With thionyl chloride; sulfuric acid; for 1h;Heating / reflux;	Example 2 Synthesis of 5-bromo-2,1,3-benzothiadiazole A mixture was prepared by mixing 4.0 g (21 mmol) of 4-bromo-o-phenylenediamine, 14 mL of thionyl chloride and 0.62 mL of concentrated sulfuric acid and was refluxed for one hour. This mixture was cooled and then poured onto ice, and a resulting precipitate was filtered and collected. This precipitate was washed with water till the waste water became neutral and then thoroughly dried to yield 4.5 g of 5-bromo-2,1,3-benzothiadiazole as a crude product (melting point, 48 to 50 C.; yield, 96.5%).
	With thionyl chloride; In N,N-dimethyl-formamide;	Preparation 1 5-Bromo-benzo[1,2,5]thiadiazole To 4-bromo-benzene-1,2-diamine (17 g, 91 mmol) was added thionyl chloride (200 ml). One drop of DMF was added to the reaction mixture. The reaction mixture was heated at reflux under argon at 80 C. overnight. The reaction mixture was cooled to room temperature and added portionwise to ice in a large beaker and neutralised with solid sodium bicarbonate. The mixture was partitioned between ethyl acetate and water. The ethyl acetate layer was collected and dried (MgSO4). The solvent was removed under reduced pressure. The title compound was isolated by column chromatography on silica gel eluding with 90% ethyl acetate/10% methanol. (12 g, 62%); 1H NMR (250 MHz, CDCl3) delta: 7.61 (1H, dd, J=9, 2 Hz), 7.82 (1H, d, J=9 Hz), 8.16 (1H, s).

Reference： [1]RSC Advances,2016,vol. 6,p. 66978 - 66989
[2]Patent: US2009/149676,2009,A1 .Location in patent: Page/Page column 5
[3]ChemMedChem,2018,vol. 13,p. 2332 - 2348
[4]Chemistry of Heterocyclic Compounds,1967,vol. 3,p. 662 - 666
Khimiya Geterotsiklicheskikh Soedinenii,1967,vol. 3,p. 839 - 844
[5]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1979,vol. 17,p. 13 - 16
[6]Journal of Heterocyclic Chemistry,1970,vol. 7,p. 629 - 633
[7]Patent: US2004/152738,2004,A1
[8]Chemistry - A European Journal,2010,vol. 16,p. 899 - 906
[9]Chemistry - A European Journal,2012,vol. 18,p. 11685 - 11694,10

3
[ 1753-75-9 ]
[ 16750-63-3 ]
5-(2-methoxyphenyl)benzo[c][1,2,5]thiadiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
74%	With lithium chloride;[1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II) dichloride; In tetrahydrofuran; 1,2-dimethoxyethane; at 20℃; for 1h;Product distribution / selectivity;	A vial was charged with Ih (7 mg, 2 mol %) and LiCl (67.0 mg, 1.6 mmol) as necessary followed by a stirbar under an inert atmosphere. The vial was then sealed with a septum and purged under an inert atmosphere after which DME (0.8 mL) was added and the suspension was stirred until 1 h had dissolved. After this time, the organohalide (0.5 mmol) and the organomagnesium (0.8 mL, 1.0 M in THF or ether, 0.8 mmol) were added (active catalyst is indicated by the reaction solution turning orange). The septum was replaced with a Teflon-lined screw cap under an inert atmosphere and the reaction stirred at RT or warmed to 60 or 70 C. until complete. After this time, the mixture was diluted with a suitable organic solvent (15 mL) and washed successively with 1 M Na3EDTA solution (prepared from EDTA and 3 equiv of NaOH), water and brine. After drying (anhydrous MgSO4) the solution was filtered, the solvent removed in vacuo, and the residue purified by flash chromatography. A summary of the substrate scope that was explored is presented in Table 8.
60%	With lithium chloride;[1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II) dichloride; In tetrahydrofuran; 1,3-dimethyl-2-imidazolidinone (DMI); at 20℃; for 1h;Product distribution / selectivity;	A vial was charged with Ih (7 mg, 2 mol %) and LiCl (67.0 mg, 1.6 mmol) as necessary followed by a stirbar under an inert atmosphere. The vial was then sealed with a septum and purged under an inert atmosphere after which DME (0.8 mL) was added and the suspension was stirred until 1 h had dissolved. After this time, the organohalide (0.5 mmol) and the organomagnesium (0.8 mL, 1.0 M in THF or ether, 0.8 mmol) were added (active catalyst is indicated by the reaction solution turning orange). The septum was replaced with a Teflon-lined screw cap under an inert atmosphere and the reaction stirred at RT or warmed to 60 or 70 C. until complete. After this time, the mixture was diluted with a suitable organic solvent (15 mL) and washed successively with 1 M Na3EDTA solution (prepared from EDTA and 3 equiv of NaOH), water and brine. After drying (anhydrous MgSO4) the solution was filtered, the solvent removed in vacuo, and the residue purified by flash chromatography. A summary of the substrate scope that was explored is presented in Table 8.

Reference： [1]Chemistry - A European Journal,2007,vol. 13,p. 150 - 157
[2]Patent: US2007/73055,2007,A1 .Location in patent: Page/Page column 13-14; 22
[3]Patent: US2007/73055,2007,A1 .Location in patent: Page/Page column 13-14; 21

4
potassium 5-methyl-thiophen-2-yltrifluoroborate [ No CAS ]
[ 1753-75-9 ]
C₁₁H₈N₂S₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
98%	With potassium carbonate;[1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II) dichloride; In methanol; at 60℃; for 6h;Product distribution / selectivity;	In air, a vial was charged with complex Ih (6.8 mg, 0.01 mmol), potassium carbonate (207 mg, 1.50 mmol), the potassium trifluoroborate (0.55 mmol) and the organohalide (0.5 mmol). The vial was sealed with a septum and purged with argon (3×). Technical grade methanol (2.0 mL) was added and the contents stirred at 60 C. for the specified period of time. The reaction was then diluted with diethyl ether (2 mL) and transferred to a round bottom flask. The reaction vial was rinsed with additional diethyl ether (2 mL) and combined with the previous dilution. Each reaction was performed in duplicate and the contents were combined, concentrated onto silica gel and purified by flash chromatography.

Reference： [1]Chemistry - A European Journal,2006,vol. 12,p. 4743 - 4748
[2]Patent: US2007/73055,2007,A1 .Location in patent: Page/Page column 11; 16

5
[ 1753-75-9 ]
2,4,6-trimethylphenyl-ZnX, X = halide [ No CAS ]
5-(2,4,6-trimethylphenyl)benzo[1,2,5]thiadiazole [ No CAS ]

Reference： [1]Chemistry - A European Journal,2006,vol. 12,p. 4749 - 4755

6
[ 1753-75-9 ]
[ 30669-83-1 ]

Reference： [1]Zhurnal Obshchei Khimii,1957,vol. 27,p. 2599,2603; engl. Ausg. S. 2656, 2659

7
[ 1753-75-9 ]
[ 72023-80-4 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1979,vol. 17,p. 13 - 16

8
[ 1753-75-9 ]
[ 49716-23-6 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1979,vol. 17,p. 13 - 16

9
[ 1753-75-9 ]
[ 72023-81-5 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1979,vol. 17,p. 13 - 16

10
[ 1753-75-9 ]
[ 32863-29-9 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1979,vol. 17,p. 13 - 16

11
[ 1753-75-9 ]
argon [ No CAS ]
[ 428817-49-6 ]

Yield	Reaction Conditions	Operation in experiment
	With diisopropylamine; In ethyl acetate;	Preparation 2 5-Trimethylsilanylethynylbenzo[1,2,5]thiadiazole A solution of <strong>[1753-75-9]5-bromo-benzo[1,2,5]thiadiazole</strong> (10 g, 80 mmol) was degassed with argon for 10 min, then copper iodide (1.53 g, 8 mmol) and bis-triphenylphospine-palladium-dichloride (1.12 g, 1.6 mmol) were added. TMS-acetylene (12.75 ml) was added via syringe followed by dropwise addition of diisopropylamine over 20 min. The reaction mixture was stirred at ambient temprature overnight. The THF was removed under reduced pressure. Ethyl acetate was added to the resulting brown oil and the mixture was filtered through celite. The residue was partitioned between ethyl acetate and water. The title compound was isolated by column chromatography using petroleum ether as the eluent (9 g, 49%); m/z (API+): 231.1 (MH+), m/z (API-): 233.1 (M).

Reference： [1]Patent: US2004/152738,2004,A1

12
[ 1753-75-9 ]
copper dichloride [ No CAS ]
di-μ-chlorobis{chlorobis(5-bromo-2,1,3-benzothiadiazole)copper(II)} [ No CAS ]

Reference： [1]Journal of general chemistry of the USSR,1989,vol. 59,p. 385 - 390
J.Gen.Chem.USSR (Engl.Transl.),1989,vol. 59,p. 435 - 441

13
di-μ-chlorobis{chlorobis(5-bromo-2,1,3-benzothiadiazole)copper(II)} [ No CAS ]
[ 1753-75-9 ]
copper dichloride [ No CAS ]

Reference： [1]Journal of general chemistry of the USSR,1989,vol. 59,p. 385 - 390
J.Gen.Chem.USSR (Engl.Transl.),1989,vol. 59,p. 435 - 441

14
[ 1753-75-9 ]
[ 917499-87-7 ]
Rh₂(O₂CCH₃)4*(5-Br-2,1,3-benzothiadiazole)2 [ No CAS ]

Reference： [1]Zhurnal Obshchei Khimii,1976,vol. 46,p. 885 - 888
Zhurnal Obshchei Khimii,1976,vol. 46,p. 888 - 892
[2]Gmelin Handbuch der Anorganischen Chemie,Gmelin Handbook: Rh: SVol.B2, 1.1.2.2.5, page 29 - 32

15
[ 1753-75-9 ]
5,5'-Bibenzo<c>thiadiazol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
73%	copper; In N,N-dimethyl-formamide; at 150℃; for 6h;Product distribution / selectivity;	Synthesis of 5,5'-bis(2,1,3-benzothiadiazole) A reaction mixture prepared by adding 4.6 g (21.4 mmol) of <strong>[1753-75-9]5-bromo-2,1,3-benzothiadiazole</strong> and 2 g (31.5 mmol) of copper powder to 10 mL of dimethylformamide was heated with stirring at 150 C. for 6 hours. This reaction mixture was cooled and then poured into water (40 mL), and a resulting precipitate was filtered and collected. After this precipitate was dried, it was extracted with benzene (20 mL*3). After combining these benzene extracts, the combined extract was dried under vacuum to complete dryness. A resulting oily residue was triturated with petroleum ether, and a mother liquor was removed to yield 2.1 g of 5,5'-bis(2,1,3-benzothiadiazole) (melting point, 61 to 62 C.; yield, 73%).

Reference： [1]Patent: US2009/149676,2009,A1 .Location in patent: Page/Page column 5

16
[ 1753-75-9 ]
[ 110556-33-7 ]
C₁₁H₁₂N₂O₂S [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 1728 - 1734

17
[ 1753-75-9 ]
[ 1314874-80-0 ]
[ 1360609-47-7 ]

Yield	Reaction Conditions	Operation in experiment
	With caesium carbonate;tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; at 90℃; for 14h;	Benzo[1 ,2,5]thiadiazol-5-yl-(8-chloro-[1 ,2,4]triazolo[1 ,5-a]pyrazin-2-yl)-amine ("BIO")100 mg (0.6 mmol) of 8-pyridin-3-yl-[1 ,2,4]triazolo[1 ,5-a]pyrazin-2-ylamine, mg (0.9 mmol) 5-bromo-2,1 ,3-benzothiadiazole, 68 mg (0.1 mmol) 9,9- dimethyl-4,5-bis(diphenylphosphino)xanthene , 578 mg (1.8 mmol) cesium carbonate and 34 mg bis(dibenzylideneacetone)palladium are dissolved in 1 ml dioxane and stirred at 90 C for 14 h. HPLC and LC-MS analysis show formation of the product (LCMS (method C): mass found (M+H+, 303), HPLC (method D) Rt (min): 3.07.

Reference： [1]Patent: WO2012/25186,2012,A1 .Location in patent: Page/Page column 116-117

18
4-bromo-1,2-phenylenediamine dihydrochloride [ No CAS ]
[ 1753-75-9 ]

Reference： [1]Journal of Physical Chemistry B,2012,vol. 116,p. 7259 - 7268

19
[ 1753-75-9 ]
[ 1380415-20-2 ]

Reference： [1]Journal of Physical Chemistry B,2012,vol. 116,p. 7259 - 7268

20
[ 1753-75-9 ]
[ 1404481-85-1 ]

Reference： [1]Chemistry - A European Journal,2012,vol. 18,p. 11685 - 11694,10

21
[ 1753-75-9 ]
[ 1168135-03-2 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium acetate; In N,N-dimethyl-formamide;	Preparation 44 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[c][1,2,5]thiadiazole Dichloro[1,1'-bis(diphenylphosphino)ferrocene]-palladium(II) (100 mg, 0.14 mmol, 0.03), potassium acetate (1.4 g, 14 mmol), and diboron bis(pinocol) ester (1.2 g, 4.7 mmol) were sequentially added to a stirred solution of <strong>[1753-75-9]5-bromobenzo[c][1,2,5]thiadiazole</strong> (1.0 g, 4.7 mmol) in N,N-dimethylformamide (12 mL) at 23 C. The resulting dark brown mixture was sealed under nitrogen, heated to 80 C., and stirred for 24 h. The cooled reaction mixture was diluted with water (500 mL) and extracted with diethyl ether (4100 mL). The combined organic layers were diluted with hexane (100 mL) and washed with water (1200 mL). The organic layer was dried (magnesium sulfate), gravity filtered, and concentrated by rotary evaporation to afford the title compound as a brown powder (960 mg, 80% yield): IR (KBr thin film) 2977 (m), 2930 (w), 1607 (w), 1471 (m) cm-1; 1H NMR (400 MHz, CDCl3) delta 8.54 (s, 1H), 7.93-8.01 (m, 2H), 1.40 (s, 12H).

Reference： [1]Patent: US2014/274702,2014,A1 .Location in patent: Page/Page column

22
[ 1753-75-9 ]
[ 23112-96-1 ]
5-(2,6-dimethoxyphenyl)benzo[c][1,2,5]thiadiazole [ No CAS ]

Reference： [1]Journal of Physical Chemistry A,2016,vol. 120,p. 1853 - 1866

23
[ 1753-75-9 ]
[ 28611-39-4 ]
5-(4-dimethylaminophenyl)benzo[c][1,2,5]thiadiazole [ No CAS ]

Reference： [1]Journal of Physical Chemistry A,2016,vol. 120,p. 1853 - 1866

24
[ 1753-75-9 ]
[ 201802-67-7 ]
5-(4-diphenylaminophenyl)benzo[c][1,2,5]thiadiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With tetrakis(triphenylphosphine) palladium(0); tetrabutylammomium bromide; sodium hydroxide; In toluene; at 120℃; for 48h;	1. 1 mmol of 5-bromobenzothiadiazole,1 mmol of triphenylamine-4-boronic acid pinacol ester,0.05 mmol of tetrakis(triphenylphosphine)palladium, 0.1 mmol of tetrabutylammonium bromide,6mmol sodium hydroxide andMix 10 ml of toluene, react at 120 C for 48 h, extract with water and dichloromethane, and combine the organic layers.After drying, the organic solvent is removed, and purified by using a mixed solvent of dichloromethane and petroleum ether as a solvent column chromatography.Obtaining 4-(benzo[c][1,2,5]thiadiazol-5-yl)-N,N-diphenylaniline

Reference： [1]Journal of Physical Chemistry A,2016,vol. 120,p. 1853 - 1866
[2]Inorganic Chemistry,2016,vol. 55,p. 8446 - 8458
[3]Patent: CN110028506,2019,A .Location in patent: Paragraph 0107-0108; 0111-0112

25
[ 1753-75-9 ]
4-trimethylsilyl-2,6-dimethoxyphenylboronic acid [ No CAS ]
5-(4-trimethylsilyl-2,6-dimethoxyphenyl)benzo[c][1,2,5]thiadiazole [ No CAS ]

Reference： [1]Journal of Physical Chemistry A,2016,vol. 120,p. 1853 - 1866

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P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 1753-75-9 ]

Quality Control of [ 1753-75-9 ]

Related Doc. of [ 1753-75-9 ]

Product Details of [ 1753-75-9 ]

Safety of [ 1753-75-9 ]

Application In Synthesis of [ 1753-75-9 ]

[ 1753-75-9 ] Synthesis Path-Upstream 1~2

[ 1753-75-9 ] Synthesis Path-Downstream 1~25

Related Functional Groups of [ 1753-75-9 ]

Bromides

Related Parent Nucleus of [ 1753-75-9 ]

Other Aromatic Heterocycles

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 1753-75-9 ]

Related Parent Nucleus of
[ 1753-75-9 ]