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Chemical Structure| 178896-79-2 Chemical Structure| 178896-79-2

Structure of 178896-79-2

Chemical Structure| 178896-79-2

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Product Details of [ 178896-79-2 ]

CAS No. :178896-79-2
Formula : C10H10F3NO
M.W : 217.19
SMILES Code : FC(C1=CC2=C(C=C1OC)CCN2)(F)F
MDL No. :MFCD12498700

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Application In Synthesis of [ 178896-79-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 178896-79-2 ]

[ 178896-79-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 170737-95-8 ]
  • [ 178896-79-2 ]
  • 2-(4-chloro-2-methoxyphenyl)-1-(5-methoxy-6-(trifluoromethyl)indolin-1-yl)ethanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
2.48 g With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20℃; for 12h; A mixture of 5-methoxy-6-(trifluoromethyl)indoline 5c (1 .5 g, 6.9 mmol), <strong>[170737-95-8]2-(4-chloro-2-methoxyphenyl)acetic acid</strong> [CAS 170737-95-8] (1 .4 g, 6.9 mmol), HATU (3.94 g, 10.4 mmol) and diisopropylethylamine (3.4 mL, 20.7 mmol) in DMF (40 mL) was stirred at room temperature for 12 h. Ice/water was added and the precipitate was filtered off. The residue was taken up with CH2CI2. The organic solution was washed with a 10% aqueous solution of K2CO3, brine, dried over MgSO , filtered and the solvent was evaporated under reduced pressure. The residue was crystallized from diisopropyl ether to give 2-(4-chloro-2-methoxy- phenyl)-1 -(5-methoxy-6-(trifluoromethyl)indolin-1 -yl)ethanone 7a (2.48 g).
 

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