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[ CAS No. 179412-96-5 ] {[proInfo.proName]}

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Chemical Structure| 179412-96-5
Chemical Structure| 179412-96-5
Structure of 179412-96-5 * Storage: {[proInfo.prStorage]}
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Product Details of [ 179412-96-5 ]

CAS No. :179412-96-5 MDL No. :MFCD20483509
Formula : C10H21NO3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 203.28 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 179412-96-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 179412-96-5 ]

[ 179412-96-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 172833-22-6 ]
  • [ 179412-96-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: NMM / tetrahydrofuran 2: NaBH4 / methanol
Stage #1: 4-(tert-butoxycarbonylamino)pentanoic acid With 4-methyl-morpholine; chloroformic acid ethyl ester In tetrahydrofuran at -10℃; for 0.166667h; Stage #2: With methanol; sodium tetrahydroborate In tetrahydrofuran at 0℃; for 0.666667h; Stage #3: With ammonium chloride In tetrahydrofuran; water 12 To a stirred solution of crude 4-[(tert-butoxycarbonyl)amino] pentanoic acid (8.1 g, 37 mmol) in THF (180mL) at-10 C was added N-methylmorpholine (4.5mL, 41 mmol) followed by ethyl chloroformate (3.9mL, 41mmol). After 10 min, NaBH4 (4.2 g, 110 mmol) was added in one portion.MeOH (360 mL) was then added slowly to the reaction mixture over a period of 20 min at0 C. The solution was stirred for an additional 20 min and then treated with aqueousNH4C1 solution. The aqueous layer was extracted with EtOAc (x 3). The combined organics were washed with brine, dried(Na2SO4), concentrated, and purified by flash chromatography to givetert-butyl (4-hydroxy-l-methylbutyl) carbamate as a colorlessoil. 1H NMR (CDC13, 500 MHz) 8 4.36 (br s, 1H), 3.67 (br s, 1H), 3.65 (t, 2H), 1.59(m, 2H), 1.46(m, 2H), 1.42 (s, 9H),1.11 (d, 3H).
  • 2
  • [ 4133-72-6 ]
  • [ 179412-96-5 ]
  • rac-methyl 5-bromo-2-((4-((tert-butoxycarbonyl)amino)-pentyl)oxy)-4-fluorobenzoate [ No CAS ]
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