Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 179412-96-5 | MDL No. : | MFCD20483509 |
Formula : | C10H21NO3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 203.28 | Pubchem ID : | - |
Synonyms : |
|
Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: NMM / tetrahydrofuran 2: NaBH4 / methanol | ||
Stage #1: 4-(tert-butoxycarbonylamino)pentanoic acid With 4-methyl-morpholine; chloroformic acid ethyl ester In tetrahydrofuran at -10℃; for 0.166667h; Stage #2: With methanol; sodium tetrahydroborate In tetrahydrofuran at 0℃; for 0.666667h; Stage #3: With ammonium chloride In tetrahydrofuran; water | 12 To a stirred solution of crude 4-[(tert-butoxycarbonyl)amino] pentanoic acid (8.1 g, 37 mmol) in THF (180mL) at-10 C was added N-methylmorpholine (4.5mL, 41 mmol) followed by ethyl chloroformate (3.9mL, 41mmol). After 10 min, NaBH4 (4.2 g, 110 mmol) was added in one portion.MeOH (360 mL) was then added slowly to the reaction mixture over a period of 20 min at0 C. The solution was stirred for an additional 20 min and then treated with aqueousNH4C1 solution. The aqueous layer was extracted with EtOAc (x 3). The combined organics were washed with brine, dried(Na2SO4), concentrated, and purified by flash chromatography to givetert-butyl (4-hydroxy-l-methylbutyl) carbamate as a colorlessoil. 1H NMR (CDC13, 500 MHz) 8 4.36 (br s, 1H), 3.67 (br s, 1H), 3.65 (t, 2H), 1.59(m, 2H), 1.46(m, 2H), 1.42 (s, 9H),1.11 (d, 3H). |