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Chemical Structure| 17954-81-3 Chemical Structure| 17954-81-3

Structure of 17954-81-3

Chemical Structure| 17954-81-3

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Product Details of [ 17954-81-3 ]

CAS No. :17954-81-3
Formula : C10H11BrO2
M.W : 243.10
SMILES Code : O=CC1=CC=C(OCCCBr)C=C1
MDL No. :MFCD08447768

Safety of [ 17954-81-3 ]

Application In Synthesis of [ 17954-81-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 17954-81-3 ]

[ 17954-81-3 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 17954-81-3 ]
  • [ 21344-90-1 ]
  • 4-(3-(4-(2-chlorophenyl)thiazol-2-ylamino)propoxy)benzaldehyde [ No CAS ]
YieldReaction ConditionsOperation in experiment
23.1% With potassium carbonate; In N,N-dimethyl-formamide; for 12h;Reflux; General procedure: To a solution of 4-(3-bromopropoxy)benzaldehyde (200.00 mg, 0.82 mmol)and 4-phenylthiazol-2-amine (144.50 mg, 0.82 mmol) in DMF (15 mL),potassium carbonate (170.00 mg, 1.23 mmol) was added. The reaction mixturewas refluxed for 12 h. The reaction mixture was quenched with water,and extracted with toluene (20 mL*3). The combined organic layer waswashed with brine, dried with anhydrous sodium sulphate, concentratedunder vacuum, then purified by flash chromatography (petroleum ether:ethyl acetate = 3:1) to afford a colorless solid. Yield 32.3percent. The procedure described for the synthesis of compound 3a can also beapplied to the synthesis of compounds 3b-o.
  • 2
  • [ 17954-81-3 ]
  • [ 21344-90-1 ]
  • ethyl (E)-2-(4-(3-(4-(2-chlorophenyl)thiazol-2-ylamino)propoxy)phenyl)ethenesulfonate [ No CAS ]
  • 3
  • [ 30235-28-0 ]
  • [ 17954-81-3 ]
  • ethyl (E)-2-(4-(3-(4-(pyridin-4-yl)thiazol-2-ylamino)propoxy)phenyl)ethenesulfonate [ No CAS ]
  • 4
  • [ 30235-28-0 ]
  • [ 17954-81-3 ]
  • 4-(3-(4-(pyridin-4-yl)thiazol-2-ylamino)propoxy)benzaldehyde [ No CAS ]
YieldReaction ConditionsOperation in experiment
8.2% With potassium carbonate; In N,N-dimethyl-formamide; for 12h;Reflux; General procedure: To a solution of 4-(3-bromopropoxy)benzaldehyde (200.00 mg, 0.82 mmol)and 4-phenylthiazol-2-amine (144.50 mg, 0.82 mmol) in DMF (15 mL),potassium carbonate (170.00 mg, 1.23 mmol) was added. The reaction mixturewas refluxed for 12 h. The reaction mixture was quenched with water,and extracted with toluene (20 mL*3). The combined organic layer waswashed with brine, dried with anhydrous sodium sulphate, concentratedunder vacuum, then purified by flash chromatography (petroleum ether:ethyl acetate = 3:1) to afford a colorless solid. Yield 32.3%. The procedure described for the synthesis of compound 3a can also beapplied to the synthesis of compounds 3b-o.
  • 5
  • [ 30709-67-2 ]
  • [ 17954-81-3 ]
  • ethyl (E)-2-(4-(3-(5-methyl-4-phenylthiazol-2-ylamino)propoxy)phenyl)ethenesulfonate [ No CAS ]
  • 6
  • [ 30709-67-2 ]
  • [ 17954-81-3 ]
  • 4-(3-(5-methyl-4-phenylthiazol-2-ylamino)propoxy)benzaldehyde [ No CAS ]
YieldReaction ConditionsOperation in experiment
29.2% With potassium carbonate; In N,N-dimethyl-formamide; for 12h;Reflux; General procedure: To a solution of 4-(3-bromopropoxy)benzaldehyde (200.00 mg, 0.82 mmol)and 4-phenylthiazol-2-amine (144.50 mg, 0.82 mmol) in DMF (15 mL),potassium carbonate (170.00 mg, 1.23 mmol) was added. The reaction mixturewas refluxed for 12 h. The reaction mixture was quenched with water,and extracted with toluene (20 mL*3). The combined organic layer waswashed with brine, dried with anhydrous sodium sulphate, concentratedunder vacuum, then purified by flash chromatography (petroleum ether:ethyl acetate = 3:1) to afford a colorless solid. Yield 32.3%. The procedure described for the synthesis of compound 3a can also beapplied to the synthesis of compounds 3b-o.
 

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Technical Information

• Alkyl Halide Occurrence • Barbier Coupling Reaction • Baylis-Hillman Reaction • Bucherer-Bergs Reaction • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Chaykovsky Reaction • Corey-Fuchs Reaction • Fischer Indole Synthesis • General Reactivity • Grignard Reaction • Hantzsch Dihydropyridine Synthesis • Henry Nitroaldol Reaction • Hiyama Cross-Coupling Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Julia-Kocienski Olefination • Kinetics of Alkyl Halides • Knoevenagel Condensation • Kumada Cross-Coupling Reaction • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Mukaiyama Aldol Reaction • Nomenclature of Ethers • Nozaki-Hiyama-Kishi Reaction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Amines • Preparation of Ethers • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Dihalides • Reactions of Ethers • Reformatsky Reaction • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Stetter Reaction • Stille Coupling • Stobbe Condensation • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • Ugi Reaction • Wittig Reaction • Wolff-Kishner Reduction

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