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Chemical Structure| 18004-62-1 Chemical Structure| 18004-62-1

Structure of 18004-62-1

Chemical Structure| 18004-62-1

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Product Details of [ 18004-62-1 ]

CAS No. :18004-62-1
Formula : C10H12Cl2N2
M.W : 231.12
SMILES Code : NCC1=NC2=CC=CC=C2C=C1.[H]Cl.[H]Cl
MDL No. :MFCD05053645
InChI Key :XPAZBFLKFMBGMF-UHFFFAOYSA-N
Pubchem ID :18507294

Safety of [ 18004-62-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 18004-62-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 18004-62-1 ]

[ 18004-62-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 18004-62-1 ]
  • [ 5760-20-3 ]
YieldReaction ConditionsOperation in experiment
82% With sodium hydroxide; In water;pH 10.0; Quinolin-2-ylmethanamine bischlorohydrate 15 (0.5 g, 2.1 mmol) was neutralized drop by drop with sodium hydroxide (1M, 30 mL) up to pH=10. The aqueous phase was extracted by CH2Cl2 (4×25 mL), then dried over magnesium sulfate, filtered, and evaporated to dryness affording the free amine 12. 82% yield; 1H NMR (300 MHz, CDCl3) delta 1.94 (2H, s, NH2), 4.16 (2H, s, CH2), 7.42 (1H, m, CHar), 7.49 (1H, m, CHar), 7.54 (1H, m, CHar), 7.68 (1H, m, CHar), 7.80 (1H, m, CHar), 8.06 (2H, m, CHar); 13C NMR (75 MHz, CDCl3) 30.72, 117.69, 123.87, 128.59, 129.08, 129.64, 131.54, 132.94, 138.50, 147.43.
 

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