[ CAS No. 18159-22-3 ]

Name: 18159-22-3|1-Benzyl-1H-pyrrole-2-carboxylic acid|97%
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Quality Control of [ 18159-22-3 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 18159-22-3 ]

Product Details of [ 18159-22-3 ]

CAS No. :	18159-22-3	MDL No. :	MFCD00894448
Formula :	C₁₂H₁₁NO₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	OGGDCEFWAMGBOB-UHFFFAOYSA-N
M.W :	201.22	Pubchem ID :	14985839
Synonyms :

Safety of [ 18159-22-3 ]

Signal Word:	Warning	Class:
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338	UN#:
Hazard Statements:	H302-H315-H319-H335	Packing Group:
GHS Pictogram:

Application In Synthesis of [ 18159-22-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 18159-22-3 ]

[ 18159-22-3 ] Synthesis Path-Downstream 1~34

1
[ 18159-22-3 ]
1-benzyl-1H-pyrrole-2-carbonyl azide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With diphenyl phosphoryl azide

Reference： [1]Mai; Artico, Marino; Esposito; Ragno; Sbardella; Massa [Il Farmaco, 2003, vol. 58, # 3, p. 231 - 241]

2
[ 634-97-9 ]
[ 18159-22-3 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium hydroxide In dimethyl sulfoxide

Reference： [1]Mai; Artico, Marino; Esposito; Ragno; Sbardella; Massa [Il Farmaco, 2003, vol. 58, # 3, p. 231 - 241]

3
[ 771-61-9 ]
[ 18159-22-3 ]
[ 942157-38-2 ]

Yield	Reaction Conditions	Operation in experiment
85%	With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 18h;

Reference： [1]Lindsay, Karl B.; Ferrando, Francese; Christensen, Kasper L.; Overgaard, Jacob; Roca, Tomas; Bennasar, M.-Lluisa; Skrydstrup, Troels [Journal of Organic Chemistry, 2007, vol. 72, # 11, p. 4181 - 4188]

4
[ 4556-23-4 ]
[ 18159-22-3 ]
S-pyridin-4-yl 1-benzyl-1H-pyrrole-2-carbothioate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
53%	With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 4h;

5
[ 18159-22-3 ]
[ 942157-19-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 85 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 18 h / 20 °C 2: 84 percent / n-BuLi / tetrahydrofuran / 3 h

6
[ 18159-22-3 ]
n-butyl 4-(1-benzyl-1H-pyrrol-2-yl)-4-oxobutanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 85 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 18 h / 20 °C 2: 84 percent / n-BuLi / tetrahydrofuran / 3 h 3: 52 percent / samarium(II) iodide / tetrahydrofuran; H₂O / 18 h / -78 °C

7
[ 18159-22-3 ]
3-(1-benzyl-1H-pyrrol-2-yl)-5-methoxymethyl-oxazolidin-2-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: (PhO)2PON₃ 2.1: Heating 3.1: n-BuLi / hexane / -78 °C 3.2: hexane 4.1: Et₃N / CH₂Cl₂ / 20 °C 5.1: MeONa / 20 °C

Reference： [1]Mai; Artico, Marino; Esposito; Ragno; Sbardella; Massa [Il Farmaco, 2003, vol. 58, # 3, p. 231 - 241]

8
[ 18159-22-3 ]
5-aminomethyl-3-(1-benzyl-1H-pyrrol-2-yl)-oxazolidin-2-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 6 steps 1.1: (PhO)2PON₃ 2.1: Heating 3.1: n-BuLi / hexane / -78 °C 3.2: hexane 4.1: Et₃N / CH₂Cl₂ / 20 °C 5.1: NaN₃ / dimethylformamide / 70 °C 6.1: H₂ / Pd/C / 20 °C

Reference： [1]Mai; Artico, Marino; Esposito; Ragno; Sbardella; Massa [Il Farmaco, 2003, vol. 58, # 3, p. 231 - 241]

9
[ 18159-22-3 ]
[ 869878-52-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: (PhO)2PON₃ 2.1: Heating 3.1: n-BuLi / hexane / -78 °C 3.2: hexane

Reference： [1]Mai; Artico, Marino; Esposito; Ragno; Sbardella; Massa [Il Farmaco, 2003, vol. 58, # 3, p. 231 - 241]

10
[ 18159-22-3 ]
3-(1-benzyl-1H-pyrrol-2-yl)-5-methylaminomethyl-oxazolidin-2-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: (PhO)2PON₃ 2.1: Heating 3.1: n-BuLi / hexane / -78 °C 3.2: hexane 4.1: Et₃N / CH₂Cl₂ / 20 °C 5.1: tetrahydrofuran / 65 °C

Reference： [1]Mai; Artico, Marino; Esposito; Ragno; Sbardella; Massa [Il Farmaco, 2003, vol. 58, # 3, p. 231 - 241]

11
[ 18159-22-3 ]
[ 869878-51-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: (PhO)2PON₃ 2: Heating

Reference： [1]Mai; Artico, Marino; Esposito; Ragno; Sbardella; Massa [Il Farmaco, 2003, vol. 58, # 3, p. 231 - 241]

12
[ 18159-22-3 ]
[ 587869-38-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: (PhO)2PON₃ 2.1: Heating 3.1: n-BuLi / hexane / -78 °C 3.2: hexane 4.1: Et₃N / CH₂Cl₂ / 20 °C 5.1: NaN₃ / dimethylformamide / 70 °C

Reference： [1]Mai; Artico, Marino; Esposito; Ragno; Sbardella; Massa [Il Farmaco, 2003, vol. 58, # 3, p. 231 - 241]

13
[ 18159-22-3 ]
[ 869878-56-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: (PhO)2PON₃ 2.1: Heating 3.1: n-BuLi / hexane / -78 °C 3.2: hexane 4.1: Et₃N / CH₂Cl₂ / 20 °C

Reference： [1]Mai; Artico, Marino; Esposito; Ragno; Sbardella; Massa [Il Farmaco, 2003, vol. 58, # 3, p. 231 - 241]

Yield	Reaction Conditions	Operation in experiment
		2 1-(Phenylmethyl)-1H-Pyrrole-2-Carboxylic Acid The 5.0 g of oil was combined with 100 ml of ethanol (ethyl alcohol) in a 250 ml round bottom flask. The mixture was heated to reflux then sodium hydroxide (3.0 g) in 15 ml of water was added. The reaction refluxed for 2 hours and was then diluted with 50 ml water. The mixture was cooled in an ice-bath then acidified by addition of 5.0 g of malonic acid. The mixture was then extracted with diethylether in a 500 ml sepratory funnel. The ether layer was washed with water and saturated sodium chloride solution (brine). The ether layer was filtered through sodium sulfate and evaporated to dryness under reduced pressure to give 2.8 g of a brown crystalline solid. The solid was recrystallized from acetonitrile to give 1.3 g of white fluffy crystals of the title compound. mp=130° C. to 133° C. In like manner, by substituting the following starting materials for benzylamine above, and following the procedure in Example 2, the following compounds can be made:
		2 1-(Phenylmethyl)-1H-Pyrrole-2-Carboxylic Acid The 5.0 g of oil was combined with 100 ml of ethanol (ethyl alcohol) in a 250 ml round bottom flask. The mixture was heated to reflux then sodium hydroxide (3.0 g) in 15 ml of water was added. The reaction refluxed for 2 hours and was then diluted with 50 ml water. The mixture was cooled in an ice-bath then acidified by addition of 5.0 g of malonic acid. The mixture was then extracted with diethylether in a 500 ml sepratory funnel. The ether layer was washed with water and saturated sodium chloride solution (brine). The ether layer was filtered through sodium sulfate and evaporated to dryness under reduced pressure to give 2.8 g of a brown crystalline solid. The solid was recrystallized from acetonitrile to give 1.3 g of white fluffy crystals of the title compound. mp =130° C. to 133° C. In like manner, by substituting the following starting materials for benzylamine above, and following the procedure in Example 2, the following compounds can be made:

15
[ 18159-23-4 ]
[ 18159-22-3 ]

Yield	Reaction Conditions	Operation in experiment
95.5%	With water; potassium hydroxide In methanol Reflux;
80%	With water; potassium hydroxide In methanol for 3h; Reflux;
	With methanol; potassium hydroxide; water at 20℃; for 8h;

With lithium hydroxide monohydrate In tetrahydrofuran; methanol; water at 20℃; for 16h;

Reference： [1]Location in patent: experimental part Mochona, Bereket; Le, Laine; Gangapuram, Madhavi; Mateeva, Nelly; Ardley, Tiffany; Redda, Kinfe K. [Journal of Heterocyclic Chemistry, 2010, vol. 47, # 6, p. 1367 - 1371]
[2]Yannakakis, Mary-Patricia; Simal, Carmen; Tzoupis, Haralambos; Rodi, Maria; Dargahi, Narges; Prakash, Monica; Mouzaki, Athanasia; Platts, James A.; Apostolopoulos, Vasso; Tselios, Theodore V. [International Journal of Molecular Sciences, 2017, vol. 18, # 6]
[3]Location in patent: body text Teng, Xin; Keys, Heather; Yuan, Junying; Degterev, Alexei; Cuny, Gregory D. [Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 11, p. 3219 - 3223]
[4]Guerra Faura, Gabriel; Nguyen, Tena; France, Stefan [Journal of Organic Chemistry, 2021, vol. 86, # 15, p. 10088 - 10104]

16
[ 15205-15-9 ]
[ 18159-22-3 ]
[ 1100566-04-8 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,p. 3219 - 3223

17
[ 2051-97-0 ]
[ 124-38-9 ]
[ 18159-22-3 ]

Yield	Reaction Conditions	Operation in experiment
80%	With dimethylaluminum chloride In hexane; toluene at 20℃; for 3h; regioselective reaction;

Reference： [1]Location in patent: experimental part Nemoto, Koji; Onozawa, Satoru; Egusa, Naoki; Morohashi, Naoya; Hattori, Tetsutaro [Tetrahedron Letters, 2009, vol. 50, # 31, p. 4512 - 4514]

18
[ 2051-97-0 ]
[ 76-02-8 ]
[ 18159-22-3 ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 1-benzyl-1H-pyrrole; trifluoroacetyl chloride In diethyl ether for 24h; Inert atmosphere; Stage #2: With water; sodium hydroxide In ethanol for 5h; Reflux;

Reference： [1]Kerr, Daniel J.; White, Jonathan M.; Flynn, Bernard L. [Journal of Organic Chemistry, 2010, vol. 75, # 21, p. 7073 - 7084]

19
[ 18159-22-3 ]
[ 51491-77-1 ]

Yield	Reaction Conditions	Operation in experiment
6.28 g	With thionyl chloride In diethyl ether for 4h; Inert atmosphere;
	With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 3h;

Reference： [1]Kerr, Daniel J.; White, Jonathan M.; Flynn, Bernard L. [Journal of Organic Chemistry, 2010, vol. 75, # 21, p. 7073 - 7084]
[2]Guerra Faura, Gabriel; Nguyen, Tena; France, Stefan [Journal of Organic Chemistry, 2021, vol. 86, # 15, p. 10088 - 10104]

20
[ 496-72-0 ]
[ 18159-22-3 ]
[ 1262222-14-9 ]

Yield	Reaction Conditions	Operation in experiment
80.14%	With polyphosphoric acid In 5,5-dimethyl-1,3-cyclohexadiene at 145℃; for 4h;

21
[ 95-83-0 ]
[ 18159-22-3 ]
[ 1262222-16-1 ]

Yield	Reaction Conditions	Operation in experiment
79%	With polyphosphoric acid In 5,5-dimethyl-1,3-cyclohexadiene at 145℃; for 4h;

22
[ 95-54-5 ]
[ 18159-22-3 ]
[ 1262222-13-8 ]

Yield	Reaction Conditions	Operation in experiment
75.4%	With polyphosphoric acid In 5,5-dimethyl-1,3-cyclohexadiene at 145℃; for 4h;

23
[ 99-56-9 ]
[ 18159-22-3 ]
[ 1262222-15-0 ]

Yield	Reaction Conditions	Operation in experiment
67%	With polyphosphoric acid In 5,5-dimethyl-1,3-cyclohexadiene at 145℃; for 4h;

24
[ 18159-22-3 ]
[ 1585225-84-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: benzotriazol-1-ol / dichloromethane / 15.5 h / 0 - 20 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 15 h / 20 °C

Reference： [1]Pelz, Nicholas F.; Bian, Zhiguo; Zhao, Bin; Shaw, Subrata; Tarr, James C.; Belmar, Johannes; Gregg, Claire; Camper, DeMarco V.; Goodwin, Craig M.; Arnold, Allison L.; Sensintaffar, John L.; Friberg, Anders; Rossanese, Olivia W.; Lee, Taekyu; Olejniczak, Edward T.; Fesik, Stephen W. [Journal of Medicinal Chemistry, 2016, vol. 59, # 5, p. 2054 - 2066]

25
[ 89756-60-5 ]
[ 18159-22-3 ]
C₁₄H₁₇N₃O₃S [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2016,vol. 59,p. 2054 - 2066

26
[ 123476-57-3 ]
[ 18159-22-3 ]

Yield	Reaction Conditions	Operation in experiment
	With water; potassium hydroxide In methanol at 70℃; for 16h;	14 Intermediate 2-17.1-l3enzyl-1H-pyrrole-2-carboxylic acid Ethyl 1-benzyl-1H-pyrrole-2-carboxylate (458 mg,2.00 mmol), potassium hydroxide (1.12 g, 20.0 mmol), water(10 mE) and methanol (50 mE) were added to a 100-mEround-bottom flask fitted with a magnetic stir bar, thermometer and condenset The resulting solution was stirred for 16 h at 70° C. The pH of the solution was adjusted to 2 with hydrochloric acid (6.0 M aqueous) and the resulting solution was extracted with ethyl acetate (3x30 mE). The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under vacuum to give 1 -benzyl- 1 Hpyrrole-2-carboxylic acid (Intermediate 2-17), which was used in the next step without purification. ECMS: (ESI) mlz 200 [M-H]

Reference： [1]Current Patent Assignee: VALO HEALTH INC - US2016/185785, 2016, A1 Location in patent: Paragraph 2020; 2021

27
[ 1193-62-0 ]
[ 18159-22-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere 1.2: 2 h / 0 - 20 °C / Inert atmosphere 2.1: potassium hydroxide; water / methanol / 3 h / Reflux

Reference： [1]Yannakakis, Mary-Patricia; Simal, Carmen; Tzoupis, Haralambos; Rodi, Maria; Dargahi, Narges; Prakash, Monica; Mouzaki, Athanasia; Platts, James A.; Apostolopoulos, Vasso; Tselios, Theodore V. [International Journal of Molecular Sciences, 2017, vol. 18, # 6]

28
[ 18159-22-3 ]
1-benzyl-1H-N-(2-guanidinoethyl)pyrrole-2-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 16 h / 0 - 20 °C 2: dichloromethane / 20 °C 3: N-iodo-succinimide; N-ethyl-N,N-diisopropylamine / methanol; dichloromethane / 24 h / 20 °C / Inert atmosphere 4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

29
[ 18159-22-3 ]
1-Benzyl-1H-N-[2-(2,3-Di-Tert-Butoxycarbonyl)Guanidinoethyl]Pyrrole-2-Carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 16 h / 0 - 20 °C 2: dichloromethane / 20 °C 3: N-iodo-succinimide; N-ethyl-N,N-diisopropylamine / methanol; dichloromethane / 24 h / 20 °C / Inert atmosphere

30
[ 57260-73-8 ]
[ 18159-22-3 ]
1-benzyl-1H-N-[2-(tert-butoxycarbonyl)aminoethyl]pyrrole-2-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
248 mg	With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 16h;

31
[ 100-39-0 ]
[ 18159-22-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere 1.2: 2 h / 0 - 20 °C / Inert atmosphere 2.1: potassium hydroxide; water / methanol / 3 h / Reflux

32
[ 18159-22-3 ]
2,2,2-trifluoroethyl 3-(1-benzyl-1H-pyrrol-2-yl)-2-diazo-3-oxopropanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 3 h / 20 °C 2: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere 3: 4-acetamidobenzenesulfonyl azide; triethylamine / acetonitrile / 20 °C

Reference： [1]Guerra Faura, Gabriel; Nguyen, Tena; France, Stefan [Journal of Organic Chemistry, 2021, vol. 86, # 15, p. 10088 - 10104]

33
[ 18159-22-3 ]
2,2,2-trifluoroethyl 3-(1-benzyl-1H-pyrrol-2-yl)-3-oxopropanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 3 h / 20 °C 2: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

Reference： [1]Guerra Faura, Gabriel; Nguyen, Tena; France, Stefan [Journal of Organic Chemistry, 2021, vol. 86, # 15, p. 10088 - 10104]

34
[ 18159-22-3 ]
2,2,2-trifluoroethyl 2-(1-benzyl-1H-pyrrol-2-yl)-5-ethoxy-4,5-dihydrofuran-3-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 3 h / 20 °C 2: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere 3: 4-acetamidobenzenesulfonyl azide; triethylamine / acetonitrile / 20 °C 4: copper(II) hexafluoroacetylacetonate / dichloromethane / 16 h / 40 °C / Inert atmosphere

Reference： [1]Guerra Faura, Gabriel; Nguyen, Tena; France, Stefan [Journal of Organic Chemistry, 2021, vol. 86, # 15, p. 10088 - 10104]

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P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 18159-22-3 ]

Quality Control of [ 18159-22-3 ]

Related Doc. of [ 18159-22-3 ]

Product Details of [ 18159-22-3 ]

Safety of [ 18159-22-3 ]

Application In Synthesis of [ 18159-22-3 ]

[ 18159-22-3 ] Synthesis Path-Downstream 1~34

Related Functional Groups of [ 18159-22-3 ]

Aryls

Carboxylic Acids

Related Parent Nucleus of [ 18159-22-3 ]

Pyrroles

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 18159-22-3 ]

Related Parent Nucleus of
[ 18159-22-3 ]