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Chemical Structure| 181772-16-7 Chemical Structure| 181772-16-7

Structure of 181772-16-7

Chemical Structure| 181772-16-7

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Product Details of [ 181772-16-7 ]

CAS No. :181772-16-7
Formula : C11H8F6O2
M.W : 286.17
SMILES Code : O=C(O)CCC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1
MDL No. :MFCD00674033
Boiling Point : No data available

Safety of [ 181772-16-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 181772-16-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 181772-16-7 ]

[ 181772-16-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1421-65-4 ]
  • [ 181772-16-7 ]
  • methyl (2S)-2-((2E)-3-(3,5-bis(trifluoromethyl)phenyl)propanamido)-3-(3,4-dihydroxyphenyl)propanoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
51.7% General procedure: To a solution of the corresponding substitutedacid (1 eq, 2.02 mmol) in dichloromethane-N,N-dimethylformamide(DMF) (3 : 1, 20 mL) was added 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) (1 eq, 2.02 mmol),N,N-diisopropylethylamine (DIEA) (1 eq, 2.02 mmol) andN-hydroxybenzotriazole (HOBt) (1 eq, 2.02 mmol). After themixture was stirred at room temperature for 30 min, correspondingamine (1 eq, 2.02 mmol) and triethylammoniumacetate (TEA) (3 eq, 6.06 mmol) was added. The solution wasstirred at room temperature for 4 h and then extracted withdichloromethane. The organic layer was washed with 1 N HClsolution, saturated NaHCO3 solution, water and brine, driedover Na2SO4 and concentrated in vacuo. The crude product was purified by silica gel column chromatography (ethylacetate-hexane, 1 : 2) to obtain the title compound.
 

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