[ CAS No. 18197-26-7 ] {[proInfo.proName]}

Name: 18197-26-7|Sodium Diformylamide|90%
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Quality Control of [ 18197-26-7 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 18197-26-7 ]

Product Details of [ 18197-26-7 ]

CAS No. :	18197-26-7	MDL No. :	MFCD00145302
Formula :	C₂H₃NNaO₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	QJXDSDLNUKLDBP-UHFFFAOYSA-M
M.W :	96.04	Pubchem ID :	10877056
Synonyms :

Calculated chemistry of [ 18197-26-7 ]

Physicochemical Properties

Num. heavy atoms :	6
Num. arom. heavy atoms :	0
Fraction Csp3 :	0.0
Num. rotatable bonds :	2
Num. H-bond acceptors :	2.0
Num. H-bond donors :	1.0
Molar Refractivity :	15.71
TPSA :	46.17 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	Yes
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-7.35 cm/s

Lipophilicity

Log Po/w (iLOGP) :	-10.65
Log Po/w (XLOGP3) :	-0.65
Log Po/w (WLOGP) :	-1.11
Log Po/w (MLOGP) :	-0.66
Log Po/w (SILICOS-IT) :	-0.52
Consensus Log Po/w :	-2.72

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	2.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	0.11
Solubility :	123.0 mg/ml ; 1.28 mol/l
Class :	Highly soluble
Log S (Ali) :	0.15
Solubility :	137.0 mg/ml ; 1.42 mol/l
Class :	Highly soluble
Log S (SILICOS-IT) :	0.31
Solubility :	195.0 mg/ml ; 2.03 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.0

Safety of [ 18197-26-7 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 18197-26-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 18197-26-7 ]
Downstream synthetic route of [ 18197-26-7 ]

[ 18197-26-7 ] Synthesis Path-Upstream 1~9

1
[ 18197-26-7 ]
[ 70-11-1 ]
[ 73286-37-0 ]

Reference： [1] Tetrahedron Letters, 1989, vol. 30, # 39, p. 5285 - 5286
[2] Synthesis, 1990, # 7, p. 615 - 618

2
[ 18197-26-7 ]
[ 70-11-1 ]
[ 5468-37-1 ]

Reference： [1] Synthesis, 1990, # 7, p. 615 - 618
[2] Tetrahedron Letters, 1989, vol. 30, # 39, p. 5285 - 5286

3
[ 77287-34-4 ]
[ 18197-26-7 ]

Yield	Reaction Conditions	Operation in experiment
85%	With sodium methylate In N,N-dimethyl-formamide at 100℃;	To a stirred mixture of sodium methoxide (0.2 kg, 3.7 mol) and DMF (1.0 L), formamide (0.35 L, 7.8 mol) was added below 50 °C. The mixture was heated to 100 °C and collected the by-product methanol as distillate. Then solvent (~0.3 L) was distilled out from the reaction mixture under reduced pressure, and then reaction mixture was cooled to 30 °C. The solid was filtered and washed with DMF (0.2 L), and dried at 75 °C under vacuum to obtain 12 (0.3 kg, 85percent).

Reference： [1] Synthesis, 1990, # 2, p. 122 - 124
[2] Journal of Organic Chemistry, 2004, vol. 69, # 25, p. 8723 - 8730
[3] Journal of Organic Chemistry, 2001, vol. 66, # 9, p. 3238 - 3241
[4] Synthetic Communications, 2015, vol. 45, # 16, p. 1864 - 1870

4
[ 18197-22-3 ]
[ 18197-26-7 ]

Reference： [1] Chemistry - An Asian Journal, 2009, vol. 4, # 10, p. 1588 - 1603

5
[ 77287-34-4 ]
[ 68-12-2 ]
[ 18197-26-7 ]

Yield	Reaction Conditions	Operation in experiment
300 g	Stage #1: at 29℃; for 0.5 h; Stage #2: at 100℃; for 5.5 h;	Example 15: Preparation of sodiumdiformylamide: Sodium methoxide (200 g) and dimethylformamide (1000 mL) are charged into a round bottom flask at 29°C and stirred for 30 minutes. Formamide (310 mL) is added drop-wise to the flask in about 30 minutes and heated the reaction mass to 100 °C and maintained for 5 hours at the same temperature. Distilled out dimethylformamide (400 mL) from the reaction mass and then the reaction mass is cooled to 30°C. The solid product is obtained by filtration and washed with dimethylformamide (200 mL) and dried under suction. The material is further dried under vacuum at 70°C for 6 hours. Yield: 300 g.

Reference： [1] Patent: EP2562151, 2013, A1, . Location in patent: Paragraph 0121

6
[ 18197-26-7 ]
[ 619-41-0 ]
[ 5467-70-9 ]

Reference： [1] Synthesis, 1990, # 7, p. 615 - 618
[2] Tetrahedron Letters, 1989, vol. 30, # 39, p. 5285 - 5286

7
[ 18197-26-7 ]
[ 536-38-9 ]
[ 5467-71-0 ]

Reference： [1] Synthesis, 1990, # 7, p. 615 - 618
[2] Tetrahedron Letters, 1989, vol. 30, # 39, p. 5285 - 5286

8
[ 18197-26-7 ]
[ 99-73-0 ]
[ 5467-72-1 ]

Reference： [1] Synthesis, 1990, # 7, p. 615 - 618
[2] Tetrahedron Letters, 1989, vol. 30, # 39, p. 5285 - 5286

9
[ 18197-26-7 ]
[ 2632-13-5 ]
[ 3883-94-1 ]

Reference： [1] Synthesis, 1990, # 7, p. 615 - 618

[ 18197-26-7 ] Synthesis Path-Downstream 1~19

1
[ 778-28-9 ]
[ 18197-26-7 ]
[ 55756-14-4 ]

Reference： [1]Synthesis,1990,p. 122 - 124

2
[ 26346-85-0 ]
[ 18197-26-7 ]
[ 129972-98-1 ]

Reference： [1]Synthesis,1990,p. 615 - 618

3
[ 26346-85-0 ]
[ 18197-26-7 ]
[ 129972-94-7 ]

Reference： [1]Synthesis,1990,p. 615 - 618

4
[ 18197-26-7 ]
[ 135-73-9 ]
[ 71350-68-0 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride 1a) EtOH, RT, 2h, 1b) 50 deg C, 30 min, 2) 30 min, reflux; Yield given. Multistep reaction;
	1.) EtOH, room temp., 2 h; 2.) HCl, room temp., 2 d,; Yield given. Multistep reaction;

Reference： [1]Yinglin, Han; Hongwen, Hu [Synthesis, 1990, # 7, p. 615 - 618]
[2]Ying-lin, Han; Hong-ven, Hu [Tetrahedron Letters, 1989, vol. 30, # 39, p. 5285 - 5286]

5
[ 18197-26-7 ]
[ 619-41-0 ]
[ 5467-70-9 ]

Reference： [1]Synthesis,1990,p. 615 - 618
[2]Tetrahedron Letters,1989,vol. 30,p. 5285 - 5286

6
[ 18197-26-7 ]
[ 536-38-9 ]
[ 5467-71-0 ]

Reference： [1]Synthesis,1990,p. 615 - 618
[2]Tetrahedron Letters,1989,vol. 30,p. 5285 - 5286

7
[ 21040-45-9 ]
[ 18197-26-7 ]
N,N-diformyl-3-phenylprop-2-en-1-ylamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
73%	With 1,1'-bis-(diphenylphosphino)ferrocene In acetonitrile at 60℃; for 3.5h;

Reference： [1]Wang; Ding [Journal of Organic Chemistry, 2001, vol. 66, # 9, p. 3238 - 3241]

8
[ 6165-75-9 ]
[ 18197-26-7 ]
C₅H₅NO₂ [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2004,vol. 69,p. 8723 - 8730

9
[ 16156-58-4 ]
[ 18197-26-7 ]
C₅H₅NO₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In toluene; acetonitrile for 12h; Heating;

Reference： [1]Hartner, Frederick W.; Hsiao, Yi; Eng, Kan K.; Rivera, Nelo R.; Palucki, Michael; Tan, Lushi; Yasuda, Nobuyoshi; Hughes, David L.; Weissman, Steven; Zewge, Daniel; King, Tony; Tschaen, Dave; Volante [Journal of Organic Chemistry, 2004, vol. 69, # 25, p. 8723 - 8730]

10
[ 18197-26-7 ]
[ 166330-03-6 ]
sodium (diformylamino)methyl trifluoroborate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		To the mixture of a diformylimide sodium salt (240 mg, 2.5 mmol) and tetrahydrofuran (10 ml), <strong>[166330-03-6]2-(bromomethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane</strong> (92%, 300 mg, 1.3 mmol) was added dropwise at room temperature. The obtained mixture was stirred at 60 C. (an outer temperature) for 20 min. To the reaction mixture, acetonitrile (10 ml) was added at 60 C. (an outer temperature), and it was stirred at the same temperature overnight. Subsequently, the reaction mixture was cooled to 0 C. (an outer temperature), sodium hydrogen fluoride (310 mg, 5.0 mmol) was added thereto at the same temperature, and then water (15 ml) was added dropwise at the same temperature. The solvents were evaporated under reduced pressure from the reaction mixture. To the obtained residue, the mixed solvent (30 ml) of acetone-methanol (20:1) was added and filtrated. The solvents were evaporated under reduced pressure from the filtrate, and then the obtained residue was washed with acetone, thereby obtaining the entitled compound (197 mg) as a crude product. This compound was not purified anymore, and was used as it was for the next reaction. MS m/e (ESI) 154(M--Na)

Reference： [1]Patent: US2008/15351,2008,A1 .Location in patent: Page/Page column 12

11
[ 18197-26-7 ]
[ 2632-10-2 ]
[ 875306-52-8 ]

Yield	Reaction Conditions	Operation in experiment
	In acetonitrile; at 20 - 70℃; for 2.5h;	Example S41; Preparation of [rac]-(4-tert-butyl-benzyl)-[2-(3,4-dichloro-phenyl)-2-hydroxy-ethyl]-amine; 804 mg of 2-bromo-1-(3,4-dichloro-phenyl)-ethanone (3 mmol) were dissolved in 15 ml acetonitrile and treated with 342 mg of sodium diformylamide (3.6 mmol) at rt. After 2.5 h additional stirring at rt, the reaction mixture was heated to 70 C., filtered and concentrated under vacuo. The residue was purified by silicagel chromatography (90 g silicagel, EtOAc/heptane 1:1), leading to 437 mg off-white solid. MS: 259.0 (M).

Reference： [1]Patent: US2006/30613,2006,A1 .Location in patent: Page/Page column 28

12
[ 18197-26-7 ]
[ 42728-62-1 ]
[ 187410-78-2 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium methylate; sodium carbonate; formamide;	ii) 4-(N-formylaminomethyl)benzophenone 150 g of formamide are stirred together with 90 mL of 30%ig sodium methylate solution for 8 hours under slight vacuum at 80 C. To the resulting solution of sodium diformylamide there are added 150 g of <strong>[42728-62-1]4-chloromethylbenzophenone</strong>. After 15 hours the suspension originally present has changed to a clear solution which is added to 1l of 10%ig sodium carbonate solution. A solid material precipitates, which is filtered off in vacuo and dried. Yield: 126 g

Reference： [1]Patent: US5859084,1999,A

13
[ 6214-15-9 ]
[ 18197-26-7 ]
[ 32503-27-8 ]
(Z)-4-amino-2-butene-1-ol·hydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
0.537 g (50%)	With hydrogenchloride In ethanol; toluene	2 Synthesis of (Z)-4-amino-2-butene-1-ol·hydrochloride: STR41 1.04 g (11 mmol) of sodium diformylamide and 0.339 g (1 mmol) of tetrabutylammonium hydrogensulfate were added to 50 ml of a toluene solution containing 1.34 g (10 mmol) of 4,7-dihydro-1,3,2-dioxathiepin-2-oxide synthesised in accordance with the method described in Chemica Scripta vol 124, 170-177, (1984), and the mixture was refluxed for 2 hours. The above reaction mixture was cooled to room temperature, and the solvent was distilled away therefrom. A residue thus obtained was dissolved in 50 ml of ethanol. With the addition of 10 ml of 12N hydrochloric acid, the reaction mixture was refluxed for 3 hours, cooled to room temperature, and concentrated under reduced pressure, so that (Z)-4-amino-2-butene-1-ol·hydrochloride was obtained in a yield of 0.537 g (50%). 1 H-NMR (δ, CD3 OD): 3.64 (d, J=7 Hz, 2H), 4.19 (d, J=7 Hz, 2H), 5.55-5.65 (m, 1H), 5.85-5.75 (m, 1H)

Reference： [1]Current Patent Assignee: UGB JAPAN - US5616711, 1997, A

14
[ 18197-26-7 ]
[ 108-95-2 ]
[ 1864-94-4 ]

Reference： [1]Zeitschrift fur Naturforschung, B: Chemical Sciences,2008,vol. 63,p. 478 - 480

15
[ 18197-26-7 ]
[ 725743-41-9 ]
C₁₀H₇ClFNO₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In acetonitrile for 2h; Reflux;	11 To a solution of the bromide compound (24 g, 90 mmol) in acetonitrile (300 mL) was added sodium diformylamide (9.0 g, 95 mmol). The mixture was heated to reflux for 2 h and cooled to r.t overnight. The mixture was filtered to remove NaBr. The filtrate was concentrated to give diformylamide intermediate as a brown oil, 23.6 g. EtOH (300 mL) and 30% HCl (90 mL) were added and the mixture was stirred at 50° C. for 5 h and cooled to room temperature overnight, during which time the product crystallized out. The solid was collected by filtration, washed with dichloromethane, and dried to constant weight to give the desired aminoketone hydrochloride as white solid (6.3 g, 31%). that was used as is in the next step.
23.6 g	In acetonitrile for 2h; Reflux;	11 To a solution of the bromide compound (24 g, 90 mmol) in acetonitrile (300 mL) was added sodium diformylamide (9.0 g, 95 mmol). The mixture was heated to reflux for 2 h and cooled to r.t overnight. The mixture was filtered to remove NaBr. The filtrate was concentrated to give diformylamide intermediate as a brown oil, 23.6 g. EtOH (300 mL) and 30% HC1 (90 mL) were added and the mixture was stirred at 50°C for 5 h and cooled to room temperature overnight, during which time the product crystallized out. The solid was collected by filtration, washed with dichloromethane, and dried to constant weight to give the desired aminoketone hydrochloride as white solid (6.3 g, 3 1%). that was sued as is in the next step.

Reference： [1]Current Patent Assignee: BAYER AG; Monsanto (in: Bayer) - US2009/48311, 2009, A1 Location in patent: Page/Page column 39
[2]Current Patent Assignee: Monsanto (in: Bayer); BAYER AG - WO2016/100766, 2016, A1 Location in patent: Paragraph 0400

16
[ 57731-17-6 ]
[ 18197-26-7 ]
[ 473693-28-6 ]

Yield	Reaction Conditions	Operation in experiment
52%	In acetonitrile at 20 - 70℃; for 7.2h;

Reference： [1]Salonen, Laura M.; Holland, Mareike C.; Kaib, Philip S. J.; Haap, Wolfgang; Benz, Jörg; Mary, Jean-Luc; Kuster, Olivier; Schweizer, W. Bernd; Banner, David W.; Diederich, François [Chemistry - A European Journal, 2012, vol. 18, # 1, p. 213 - 222]

17
[ 6065-32-3 ]
[ 18197-26-7 ]
[ 1218810-49-1 ]

Yield	Reaction Conditions	Operation in experiment
96%	With sodium iodide In acetonitrile Reflux;	1 5.1.1 Ethyl (2E)-4-(diformylamino)but-2-enoate (2b) A solution of ethyl-4-bromo-crotonate 2a (1 g, 5.18 mmol), diformylimide sodium salt (0.59 g, 6.22 mmol) and sodium iodide (0.78 g, 5.18 mmol) in dry acetonitrile (25 mL) was stirred under reflux overnight. The solvent was evaporated under vacuum and the residue partitioned between dichloromethane and water (1:1, 40 mL). The aqueous phase was back-extracted with dichloromethane (3 * 15 mL) and the combined organic layers were dried over Na2SO4. The solvent was evaporated under vacuum and the residue purified by flash chromatography (hexane-EtOAc 6:4) to obtain the title compound as a light-brown solid (0.92 g, 96% yield). In alternative, Et2O was added to the deep brown oil residue to obtain the product as a crystalline solid. 1H NMR (400 MHz, DMSO-d6) δ 9.00 (s, 2H), 6.77 (dt, J = 15.8, 4.5 Hz, 1H), 5.87 (dt, J = 15.8, 2.0 Hz, 1H), 4.25 (dd, J = 4.5, 2 Hz 2H), 4.11 (q, J = 7.1 Hz, 2H), 1.20 (t, J = 7.1 Hz, 3H); LCMS: m/z 208 [M+Na]+ at rt 3.32 min; HRMS (ESI) calcd for C8H11NNaO4 [M+Na]+ 208.0580 found 208.0581.

Reference： [1]Casuscelli, Francesco; Ardini, Elena; Avanzi, Nilla; Casale, Elena; Cervi, Giovanni; D'Anello, Matteo; Donati, Daniele; Faiardi, Daniela; Ferguson, Ronald D.; Fogliatto, Gianpaolo; Galvani, Arturo; Marsiglio, Aurelio; Mirizzi, Danilo G.; Montemartini, Marisa; Orrenius, Christian; Papeo, Gianluca; Piutti, Claudia; Salom, Barbara; Felder, Eduard R. [Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 23, p. 7364 - 7380]

18
[ 18197-26-7 ]
[ 23489-36-3 ]
2-N,N-diformylamino-1-(benzofuran-2-yl)ethanone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
99%	In acetonitrile at 20 - 70℃; for 2.5h; Inert atmosphere;	4.7 _{RRN,133,135,137}General procedure for the synthesis of benzofuryl N,N-diformylamino ketones General procedure: A mixture of the corresponding benzofuryl α-bromo ketone 19-22 (10.0 mmol) and sodium diformylamide (1.00 g, 10.5 mmol) in acetonitrile (50 mL) was stirred at rt for 1.5 h and then heated at 70 °C for 1 h. The hot mixture was filtered and the precipitated NaBr was washed with hot acetonitrile (20 mL). The combined filtrates were evaporated in vacuo and the product was crystallized from hexane/diethyl ether 1:1 to give a yellow solid . 4.7.1 2-N,N-Diformylamino-1-(benzofuran-2-yl)ethanone 23 2.30 g, 99% yield , mp 122-123 °C. 1H NMR (300 MHz, CDCl3): δ = 5.11 (s, 2H, CH2), 7.35 (ddd, J = 7.8, 6.9, 1.2 Hz, 1H), 7.53 (ddd, J = 8.4, 6.9, 1.2 Hz, 1H), 7.60 (ddd, J = 8.4, 1.8, 0.9 Hz, 1H), 7.63 (d, J = 0.9 Hz, 1H), 7.74 (ddd, J = 7.8, 1.2, 0.9 Hz, 1H), 9.05 (s, 2H, 2xCHO) ppm. 13C NMR (75 MHz, CDCl3): δ = 44.7 (CH2), 112.5 (CH), 113.8 (CH), 123.5 (CH), 124.3 (CH), 126.7 (C), 128.9 (CH), 150.5 (C), 155.7 (C), 163.1 (2xCHO), 181.4 (CO) ppm. Anal. calcd for C12H9NO4: C, 62.34; H, 3.92; N, 6.05. Found: C, 62.34; H, 4.01; N, 6.14.

Reference： [1]Tafelska-Kaczmarek, Agnieszka; Krzemiński, Marek P.; Ćwiklińska, Marta [Tetrahedron, 2017, vol. 73, # 27-28, p. 3883 - 3897]

19
[ 7575-93-1 ]
[ 18197-26-7 ]
C₃H₂⁽²⁾H₃NO₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In acetonitrile; at 65℃;Large scale;	To a glass-lined reactor flushed with nitrogen were charged water (16.3 L/kg) and sodium hydroxide (3.3 kg, 3.0 equiv). The mixture was aged till sodium hydroxide reached full dissolution. The crude was cooled to 0 C. dr-Methanol (1.0 kg) and THF (4.5 L/kg) were charged. A solution of TsCl (6.3 kg, 1.2 equiv) in THF (6.3 kg, 7.1 L/kg) was added over the course of 2 h. The crude was agitated at 0 C until reaction reached completion. The batch was warmed to 20 C, The layers were separated. The collected organic layer was diluted with MTBE (4.0 kg, 5.4 L/kg), washed with brine twice (25 wt%, 4.0 kg followed by 12 kg). The organic layer was distilled under vacuum until total volume became approximately 10 L/kg. Two put/take distillations with ACN (2 c 10 L/kg) were undertaken for azeotropic drying. The crude was cooled to 20 C. ACN (10.0 kg, 12.8 L/kg) and NaN(CHO)?. (3.3 kg, 1.2 equiv.) were added. The erode was heated to 65 C and agitated until reaction reached completion. After cooling down to 5 C, the mixture was filtered, and the crude cake was washed with ACN twice (2 x 2.5 kg, 2 x 3.2 L/kg). The combined filtrates ware distilled under vacuum until total volume became approximately 3 L/kg. The crude was cooled to 20 C. Compound 12 was isolated as an oil with 80-85 wt% in 60-70% yield.

Reference： [1]Patent: WO2019/232138,2019,A1 .Location in patent: Page/Page column 21

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P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 18197-26-7 ] {[proInfo.proName]}

Quality Control of [ 18197-26-7 ]

Related Doc. of [ 18197-26-7 ]

Product Details of [ 18197-26-7 ]

Calculated chemistry of [ 18197-26-7 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 18197-26-7 ]

Application In Synthesis of [ 18197-26-7 ]

[ 18197-26-7 ] Synthesis Path-Upstream 1~9

[ 18197-26-7 ] Synthesis Path-Downstream 1~19

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry