There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
Structure of 26346-85-0
*Storage: {[sel_prStorage]}
*Shipping: {[sel_prShipping]}
The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
4.5
*For Research Use Only !
Change View
Size | Price | VIP Price | US Stock |
Global Stock |
In Stock | ||
{[ item.pr_size ]} |
Inquiry
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.discount_usd) ]} {[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} |
Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]} | Inquiry {[ item.pr_usastock ]} In Stock Inquiry - | {[ item.pr_chinastock ]} {[ item.pr_remark ]} In Stock 1-2 weeks - Inquiry - | Login | - + | Inquiry |
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days
1-2weeks
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price, item.pr_usd) ]}
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
In Stock
- +
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Dinh, Le Vi ; Dangerfield, Jesse ; DeBono, Aaron ; Keller, Andrew N ; Josephs, Tracy M ; Gregory, Karen J , et al.
Abstract: The calcium-sensing receptor (CaSR) is a validated therapeutic target in the treatment of hyperparathyroidism and related diseases. The CaSR ago-positive allosteric modulator (PAM), AC265347 (1), exhibits a chemically and pharmacologically unique profile compared to current approved CaSR PAM therapeutics. Herein, we report a series of ‘next-generation’ analogues of AC265347, investigating the impact of structural modifications at the stereogenic centre on CaSR PAM activity. Compounds 5 and 7b featuring the alcohol functional group showed ago-PAM profiles comparable to 1, whilst compounds 6, 7 and 9 devoid of this functionality were ‘pure’ PAMs with no intrinsic agonism. These novel chemical tools provide an opportunity to explore the therapeutic potential of AC265347-like PAMs as a function of affinity, cooperativity and intrinsic agonism.
Show More >
Keywords: positive allosteric modulator ; PAM ; calcium-sensing receptor ; AC265347 ; stereogenic centre
Show More >
CAS No. : | 26346-85-0 |
Formula : | C10H11BrO |
M.W : | 227.09 |
SMILES Code : | CC1=CC=C(C(CBr)=O)C(C)=C1 |
MDL No. : | MFCD00017872 |
InChI Key : | GSCCVWPVPFIRJP-UHFFFAOYSA-N |
Pubchem ID : | 2063450 |
GHS Pictogram: |
![]() |
Signal Word: | Danger |
Hazard Statements: | H314 |
Precautionary Statements: | P280-P305+P351+P338-P310 |
Class: | 8 |
UN#: | 3261 |
Packing Group: | Ⅲ |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
52% | With copper(I) bromide; In ethyl acetate; for 3h;Heating / reflux; | Reference Example 1 (2',4'-dimethyl)phenyl-2-bromoacetophenone (1) (2',4'-Dimethyl)-2-acetophenone (14.8 g, 100 mmol) was dissolved in ethyl acetate (200 ml) and copper bromide (45.0 g, 200 mmol) was added. The mixture was heated under reflux for 3 hrs. After cooling, solid was filtered off. The filtrate was concentrated under reduced pressure and the residue was purified by silica gel column chromatography, which was then converted to a powder from isopropyl ether to give the title compound (11.9 g, 52%). 1H-NMR (200Hz, CDCl3) δ: 2.37(3H, s), 2.52 (3H, s), 4.42 (2H, s), 7.09 (1H, d, J = 7.0 Hz), 7.11(1H, s), 7.62 (1H, d, J = 7.0 Hz). |
With hydrogen bromide; bromine; acetic acid; at 0 - 5℃; | General procedure: General procedure to obtainα-bromoacetophenonederivatives Acetophenone derivative (10 mmol) was solved in acetic acid(50 mL) and hydrobromic acid (0.5 mL) mixture. Bromine(10 mmol, 0.52 mL) was added dropwise to this mixture at 0-5Ctemperatureandthemixturewasstirredfor6-7h.Afterthisperiod, the mixture was poured into ice-water, collapsed portionwas filtrated and after dryness it was crystallized from ethanol. | |
With N-Bromosuccinimide; toluene-4-sulfonic acid; In ethyl acetate; at 20℃; for 12h; | 0.22g (1.5mmol) 2,4- dimethyl acetophenone, 0.27g (1.5mmol) N- bromosuccinimide and 0.03g (0.15mmol) of p-toluenesulfonic acid dissolved in 15mL ethyl acetate. The reaction was stirred for 12 hours at room temperature, TLC tracking, completion of the reaction, deionized water (3 × 10mL) and washed, the organic solvent was removed under reduced pressure to give the crude product α- bromo - (2,4-dimethyl) phenylacetyl ketone, 95% yield, was used directly without purification in the next reaction. |
With copper(ll) bromide; In ethyl acetate; at 80℃;Inert atmosphere; | General procedure: To a solution of 2-ethoxyacetophenone (4.71 g, 28.7 mmol) inAcOEt was added copper bromide (7.37 g, 31.6 mmol). The solutionwas heated at 80 C under nitrogen protection. When the solid in theflask turned from black to white, the solution was cooled to roomtemperature. The solid was removed by filtration. The filter cake waswashed with AcOEt. The combined filtrates were concentrated in vacuoto afford G (6.14 g, 88.08%) which was used directly in the next stepwithout purification. |
A612086 [75840-13-0]
2-Bromo-1-(2,5-dimethylphenyl)ethanone
Similarity: 1.00
A500938 [593270-22-5]
2-Bromo-1-(2-ethylphenyl)ethanone
Similarity: 1.00
A682078 [67159-34-6]
2-Bromo-1-(2,3,5,6-tetramethylphenyl)ethanone
Similarity: 1.00
A342337 [51012-65-8]
2-Bromo-1-(o-tolyl)ethan-1-one
Similarity: 1.00
A612086 [75840-13-0]
2-Bromo-1-(2,5-dimethylphenyl)ethanone
Similarity: 1.00
A500938 [593270-22-5]
2-Bromo-1-(2-ethylphenyl)ethanone
Similarity: 1.00
A682078 [67159-34-6]
2-Bromo-1-(2,3,5,6-tetramethylphenyl)ethanone
Similarity: 1.00
A342337 [51012-65-8]
2-Bromo-1-(o-tolyl)ethan-1-one
Similarity: 1.00
A612086 [75840-13-0]
2-Bromo-1-(2,5-dimethylphenyl)ethanone
Similarity: 1.00
A500938 [593270-22-5]
2-Bromo-1-(2-ethylphenyl)ethanone
Similarity: 1.00
A682078 [67159-34-6]
2-Bromo-1-(2,3,5,6-tetramethylphenyl)ethanone
Similarity: 1.00
A342337 [51012-65-8]
2-Bromo-1-(o-tolyl)ethan-1-one
Similarity: 1.00