18207-47-1|2,2,2-Trifluoro-1-(furan-2-yl)ethanone| Ambeed

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Quality Control of [ 18207-47-1 ] Purity: 96% SDS Specification

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Product Details of [ 18207-47-1 ]

CAS No. :	18207-47-1
Formula :	C₆H₃F₃O₂
M.W :	164.08
SMILES Code :	FC(F)(F)C(=O)C1=CC=CO1
MDL No. :	MFCD07380746
InChI Key :	MAZDPKNERLXXOV-UHFFFAOYSA-N
Pubchem ID :	140350

Safety of [ 18207-47-1 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 18207-47-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 18207-47-1 ]

[ 18207-47-1 ] Synthesis Path-Downstream 1~35

1
[ 110-00-9 ]
[ 407-25-0 ]
[ 18207-47-1 ]

References: [1]Bulletin of the Academy of Sciences of the USSR Division of Chemical Science,1987,vol. 36,p. 2631 - 2633.
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya,1987,p. 2834 - 2837.
[2]Tetrahedron Letters,1991,vol. 32,p. 2003 - 2004.
[3]Journal of the Chinese Chemical Society,2016,vol. 63,p. 345 - 352.

2
[ 110-86-1 ]
[ 527-69-5 ]
bis(trifluoromethyl)cadmium*glyme [ No CAS ]
[ 31174-04-6 ]
[ 18207-47-1 ]
[ 144459-46-1 ]

References: [1]Journal of Fluorine Chemistry,1992,vol. 56,p. 215 - 237.

3
[ 527-69-5 ]
bis(trifluoromethyl)cadmium*glyme [ No CAS ]
[ 31174-04-6 ]
[ 18207-47-1 ]
[ 144459-46-1 ]

References: [1]Journal of Fluorine Chemistry,1992,vol. 56,p. 215 - 237.

4
[ 527-69-5 ]
[ 31174-04-6 ]
[ 18207-47-1 ]
[ 144459-46-1 ]

References: [1]Journal of Fluorine Chemistry,1992,vol. 56,p. 215 - 237.

5
[ 18207-47-1 ]
[ 113452-65-6 ]
[ 113452-66-7 ]

References: [1]Journal of Organic Chemistry,1988,vol. 53,p. 1607 - 1611.

6
[ 75-77-4 ]
[ 18207-47-1 ]
[ 210302-64-0 ]

References: [1]Tetrahedron Letters,1998,vol. 39,p. 3741 - 3744.
[2]Chemical Communications,1999,p. 1323 - 1324.
[3]Journal of Organic Chemistry,1999,vol. 64,p. 6717 - 6723.
[4]Journal of Fluorine Chemistry,2001,vol. 112,p. 343 - 347.
[5]Organic Letters,2004,vol. 6,p. 2733 - 2736.

7
[ 994-30-9 ]
[ 18207-47-1 ]
2-(1-triethylsiloxy-2,2-difluoroethenyl)furan [ No CAS ]

References: [1]Tetrahedron Letters,1998,vol. 39,p. 3741 - 3744.
[2]Journal of Organic Chemistry,1999,vol. 64,p. 6717 - 6723.

8
[ 18207-47-1 ]
[ 18162-48-6 ]
tert-Butyl-(2,2-difluoro-1-furan-2-yl-vinyloxy)-dimethyl-silane [ No CAS ]

References: [1]Tetrahedron Letters,1998,vol. 39,p. 3741 - 3744.

9
[ 2687-43-6 ]
[ 18207-47-1 ]
[ 413600-00-7 ]
[ 413599-92-5 ]

References: [1]Tetrahedron Asymmetry,2001,vol. 12,p. 2309 - 2313.

10
[ 18207-47-1 ]
(Z)-2,2,2-trifluoro-1-(furan-2-yl)ethanone oxime [ No CAS ]
[ 413599-98-1 ]

References: [1]Tetrahedron Asymmetry,2001,vol. 12,p. 2309 - 2313.

11
[ 18207-47-1 ]
[ 500719-87-9 ]
[ 6919-61-5 ]
2,4-Di-furan-2-yl-5-[2,2,2-trifluoro-eth-(Z)-ylidene]-2,4-bis-trifluoromethyl-[1,3]dioxolane [ No CAS ]

References: [1]Tetrahedron Letters,2003,vol. 44,p. 7213 - 7216.

12
[ 18207-47-1 ]
2,2-difluoro-1,2-bis(2-furyl)ethan-1-one [ No CAS ]

References: [1]Organic Letters,2004,vol. 6,p. 2733 - 2736.

13
[ 18207-47-1 ]
2,2,3,3-tetrafluoro-1,4-bis(2-furyl)butane-1,4-dione [ No CAS ]

References: [1]Organic Letters,2004,vol. 6,p. 2733 - 2736.

14
[ 18207-47-1 ]
rac-2,2,2-trifluoro-1-(furan-2-yl)ethanamine [ No CAS ]

References: [1]Tetrahedron Asymmetry,2001,vol. 12,p. 2309 - 2313.
[2]Tetrahedron Asymmetry,2001,vol. 12,p. 2309 - 2313.

15
[ 18207-47-1 ]
[ 413600-00-7 ]

References: [1]Tetrahedron Asymmetry,2001,vol. 12,p. 2309 - 2313.

16
[ 18207-47-1 ]
[ 413599-92-5 ]

References: [1]Tetrahedron Asymmetry,2001,vol. 12,p. 2309 - 2313.

17
[ 18207-47-1 ]
2-bromo-2,2-difluoro-1-(furan-2-yl)ethan-1-one [ No CAS ]

References: [1]Journal of Fluorine Chemistry,2001,vol. 112,p. 343 - 347.

18
[ 18207-47-1 ]
[ 410522-47-3 ]

References: [1]Journal of Fluorine Chemistry,2001,vol. 112,p. 343 - 347.

19
[ 18207-47-1 ]
2,2-difluoro-1-furan-2-yl-3-hydroxy-4-methylpentan-1-one [ No CAS ]

References: [1]Journal of Fluorine Chemistry,2001,vol. 112,p. 343 - 347.

20
[ 70783-48-1 ]
[ 18207-47-1 ]

Yield	Reaction Conditions	Operation in experiment
78%	With water; Dess-Martin periodane; In dichloromethane; at 20℃; for 3h;	To a solution of alcohol from above (2.6g) in CH2CI2 at room temperature was added Dess-Martin reagent (10G) portionwise and 1 drop of water. After stirring for 3hr at room temperature, 10% NA2S203 (60ML) was added and after stirring overnight, the solid was filtered off and the filtrate was extracted with CH2CI2. The organic layer was washed with saturated'sodium bicarbonate, dried with MGS04, filtered and concentrated in vacuo. Ether/hexane (1: 2; 30ML) was added to the residue, filtered, and filtrate concentrated in vacuo to give the product (2g, 78%).
78%		To a solution of alcohol from above (2.6 g) in CH C12 at room temperature was added Dess-Martin reagent (10 g) portionwise and 1 drop of water. After stirring for 3 hr at room temperature, 10% Na2S2O3 (60 ml) was added and after stirring overnight, the solid was filtered off and the filtrate was extracted with CH2C12. The organic layer was washed with saturated sodium bicarbonate, dried with MgSO4, filtered and concentrated in vacuo. Ether/hexane (1:2; 30 ml) was added to the residue, filtered, and filtrate concentrated in vacuo to give the product (2 g, 78%).
78%	With Dess-Martin periodane; sodium sulfite; In dichloromethane; at 20℃;	To a solution of alcohol from above (2.6 g) in CH2Cl2 at room temperature was added Dess-Martin reagent (10 g) portionwise and 1 drop of water. After stirring for 3 hr at room temperature, 10% Na2S2O3 (60 ml) was added and after stirring overnight, the solid was filtered off and the filtrate was extracted with CH2Cl2. The organic layer was washed with saturated sodium bicarbonate, dried with MgSO4, filtered and concentrated in vacuo. Ether/hexane (1:2; 30 ml) was added to the residue, filtered, and filtrate concentrated in vacuo to give the product (2 g, 78%).

78%		Step B; To a solution of alcohol from above (2.6g) in CH2CI2 at room temperature was added Dess-Martin reagent (10g) portionwise and 1 drop of water. After stirring for 3hr at room temperature, 10% Na2S203 (60ml) was added and after stirring overnight, the solid was filtered off and the filtrate was extracted with CH2CI2. The organic layer was washed with saturated sodium bicarbonate, dried with MgS04, filtered and concentrated in vacuo. Ether/hexane (1: 2; 30ml) was added to the residue, filtered, and filtrate concentrated in vacuo to give the product (2g, 78%).
78%	With water; Dess-Martin periodane; In dichloromethane; at 20℃; for 3h;	To a solution of alcohol from above (2.6g) in CH2CI2 at room temperature was added Dess-Martin reagent (10g) portionwise and 1 drop of water. After stirring for 3hr at room temperature, 10% Na2S203 (60ml) was added and after stirring overnight, the solid was filtered off and the filtrate was extracted with CH2CI2. The organic layer was washed with saturated sodium bicarbonate, dried with MgS04, filtered and concentrated in vacuo. Ether/hexane (1: 2; 30mut) was added to the residue, filtered, and filtrate concentrated in vacuo to give the product (2g, 78%).

References: [1]Patent: WO2004/33440,2004,A1 .Location in patent: Page 182-183.
[2]Patent: US2004/147559,2004,A1 .Location in patent: Page 89; 90.
[3]Patent: US2004/106794,2004,A1 .Location in patent: Page 92.
[4]Patent: WO2005/66147,2005,A1 .Location in patent: Page/Page column 154-155.
[5]Patent: WO2005/68460,2005,A1 .Location in patent: Page/Page column 157-158.
[6]Angewandte Chemie - International Edition,2018,vol. 57,p. 12333 - 12337.
Angew. Chem.,2018,vol. 130,p. 12513 - 12517,5.

21
[ 527-69-5 ]
[ 81290-20-2 ]
[ 18207-47-1 ]

References: [1]Journal of Fluorine Chemistry,2007,vol. 128,p. 1385 - 1389.

22
[ 98-01-1 ]
[ 18207-47-1 ]
[ 1244570-35-1 ]
(R)-3,3,3-trifluoro-1,2-di(furan-2-yl)-2-hydroxypropan-1-one [ No CAS ]

References: [1]Chemical Communications,2010,vol. 46,p. 6282 - 6284.

23
[ 18207-47-1 ]
[ 1283536-78-6 ]
[ 1283536-91-3 ]
[ 1283536-93-5 ]

References: [1]Chemistry of Heterocyclic Compounds,2011,vol. 46,p. 1271 - 1278.

24
[ 18207-47-1 ]
[ 1283536-78-6 ]
[ 1283536-91-3 ]

References: [1]Chemistry of Heterocyclic Compounds,2011,vol. 46,p. 1271 - 1278.

25
[ 18207-47-1 ]
[ 1283536-78-6 ]

References: [1]Chemistry of Heterocyclic Compounds,2011,vol. 46,p. 1271 - 1278.

26
[ 18207-47-1 ]
[ 107-15-3 ]
[ 1283536-75-3 ]

References: [1]Chemistry of Heterocyclic Compounds,2011,vol. 46,p. 1271 - 1278.

27
[ 14796-89-5 ]
[ 18207-47-1 ]
[ 202869-53-2 ]