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[ CAS No. 18637-83-7 ] {[proInfo.proName]}

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Product Details of [ 18637-83-7 ]

CAS No. :18637-83-7 MDL No. :MFCD00043067
Formula : C8H6N4O2 Boiling Point : -
Linear Structure Formula :- InChI Key :ONRNRVLJHFFBJG-UHFFFAOYSA-N
M.W : 190.16 Pubchem ID :100439
Synonyms :

Safety of [ 18637-83-7 ]

Signal Word:Danger Class:8
Precautionary Statements:P280-P305+P351+P338-P310 UN#:3259
Hazard Statements:H302-H312-H314 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 18637-83-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 18637-83-7 ]

[ 18637-83-7 ] Synthesis Path-Downstream   1~42

  • 1
  • [ 288-32-4 ]
  • [ 79-37-8 ]
  • [ 18637-83-7 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine In chloroform at -10℃; for 0.25h;
With N-ethyl-N,N-diisopropylamine In chloroform at -30 - -10℃; DMF, N,N-dicyclohexylmethylamine or 2,6-di-t-butylpyridine; Title compound not separated from byproducts;
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran for 1h;
In acetonitrile for 0.0833333h; Ambient temperature;
In acetonitrile at 20℃; for 0.0833333h;
With N-ethyl-N,N-diisopropylamine In chloroform at 0℃; for 0.25h; Inert atmosphere;

  • 2
  • [ 2745-26-8 ]
  • [ 18637-83-7 ]
  • 2-Furan-2-yl-1-imidazol-1-yl-ethanone [ No CAS ]
  • 3
  • [ 79-37-8 ]
  • [ 18156-74-6 ]
  • [ 18637-83-7 ]
YieldReaction ConditionsOperation in experiment
97% In benzene at 25℃; for 81h;
  • 4
  • [ 932-31-0 ]
  • [ 18637-83-7 ]
  • [ 2048-07-9 ]
YieldReaction ConditionsOperation in experiment
80% In tetrahydrofuran at -50℃; for 0.25h;
  • 5
  • [ 60-33-3 ]
  • [ 18637-83-7 ]
  • [ 64833-94-9 ]
YieldReaction ConditionsOperation in experiment
89% With N-ethyl-N,N-diisopropylamine In chloroform at 0℃; for 1h;
In chloroform at 45℃; for 1h;
  • 6
  • [ 463-40-1 ]
  • [ 18637-83-7 ]
  • [ 64833-93-8 ]
YieldReaction ConditionsOperation in experiment
In chloroform at 45℃; for 1h;
With N-ethyl-N,N-diisopropylamine In chloroform at 0℃; for 1h;
  • 7
  • [ CAS Unavailable ]
  • [ 18637-83-7 ]
  • [ 64833-94-9 ]
YieldReaction ConditionsOperation in experiment
88% With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0℃; for 1h;
In N,N-dimethyl-formamide at 60℃; for 1h;
  • 8
  • [ 106942-15-8 ]
  • [ 18637-83-7 ]
  • [ 114601-53-5 ]
YieldReaction ConditionsOperation in experiment
56% With lithium diisopropyl amide In tetrahydrofuran from -78 deg C to 0 deg C;
With n-butyllithium; diisopropylamine 1.) THF, hexane, -78 deg C, 30 min, 2.) -78 deg C, 1.2 h; Yield given. Multistep reaction;
  • 10
  • [ CAS Unavailable ]
  • [ 18637-83-7 ]
  • [ 64833-94-9 ]
YieldReaction ConditionsOperation in experiment
74% With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0℃; for 1h;
In N,N-dimethyl-formamide at 60℃; for 1h;
  • 11
  • [ 18637-83-7 ]
  • [ 21450-64-6 ]
  • [ 1225-22-5 ]
YieldReaction ConditionsOperation in experiment
70% In tetrahydrofuran at -30℃; for 15h;
  • 13
  • [ 288-32-4 ]
  • [ 16536-30-4 ]
  • [ 51-28-5 ]
  • [ 18637-83-7 ]
YieldReaction ConditionsOperation in experiment
In acetonitrile at 5.8 - 44.7℃; stoped-flow technique; kinetics and mechanism of the nucleophilic substitution reaction; activation energy; spectral study; effect of imidazole concentration of rate constant; effect of triethylamine;
  • 14
  • [ 104-01-8 ]
  • [ 100-39-0 ]
  • [ 71989-26-9 ]
  • [ 102410-65-1 ]
  • [ 18637-83-7 ]
  • (S)-1-[(S)-1-(Benzylamino-methyl)-5-(benzyl-methyl-amino)-pentyl]-4-[2-(4-methoxy-phenyl)-ethyl]-5-phenyl-piperazine-2,3-dione [ No CAS ]
  • 15
  • [ 4919-33-9 ]
  • [ 100-39-0 ]
  • [ 71989-26-9 ]
  • [ 102410-65-1 ]
  • [ 18637-83-7 ]
  • (S)-1-[(S)-1-(Benzylamino-methyl)-5-(benzyl-methyl-amino)-pentyl]-4-[2-(4-ethoxy-phenyl)-ethyl]-5-phenyl-piperazine-2,3-dione [ No CAS ]
  • 16
  • [ 5807-30-7 ]
  • [ 100-39-0 ]
  • [ 71989-26-9 ]
  • [ 102410-65-1 ]
  • [ 18637-83-7 ]
  • (S)-1-[(S)-1-(Benzylamino-methyl)-5-(benzyl-methyl-amino)-pentyl]-4-[2-(3,4-dichloro-phenyl)-ethyl]-5-phenyl-piperazine-2,3-dione [ No CAS ]
  • 17
  • [ 1460-16-8 ]
  • [ 100-39-0 ]
  • [ 71989-26-9 ]
  • [ 102410-65-1 ]
  • [ 18637-83-7 ]
  • (S)-1-[(S)-1-(Benzylamino-methyl)-5-(benzyl-methyl-amino)-pentyl]-4-cycloheptylmethyl-5-phenyl-piperazine-2,3-dione [ No CAS ]
  • 18
  • [ 622-47-9 ]
  • [ 100-39-0 ]
  • [ 71989-26-9 ]
  • [ 102410-65-1 ]
  • [ 18637-83-7 ]
  • (S)-1-[(S)-1-(Benzylamino-methyl)-5-(benzyl-methyl-amino)-pentyl]-5-phenyl-4-(2-p-tolyl-ethyl)-piperazine-2,3-dione [ No CAS ]
  • 19
  • [ 100-39-0 ]
  • [ 71989-26-9 ]
  • [ 102410-65-1 ]
  • [ 18637-83-7 ]
  • [ 4942-47-6 ]
  • (S)-4-(2-Adamantan-1-yl-ethyl)-1-[(S)-1-(benzylamino-methyl)-5-(benzyl-methyl-amino)-pentyl]-5-phenyl-piperazine-2,3-dione [ No CAS ]
  • 20
  • [ 288-32-4 ]
  • [ 1165-91-9 ]
  • [ 18637-83-7 ]
  • 21
  • [ 2620-50-0 ]
  • [ 104-03-0 ]
  • [ 136030-33-6 ]
  • [ 18637-83-7 ]
  • <i>N</i>-benzo[1,3]dioxol-5-ylmethyl-2-[4-(1,3,4-trioxo-1,3,4,6,11,11a-hexahydro-pyrazino[1,2-<i>b</i>]isoquinolin-2-yl)-phenyl]-acetamide [ No CAS ]
  • 22
  • [ 104-03-0 ]
  • [ 78-81-9 ]
  • [ 136030-33-6 ]
  • [ 18637-83-7 ]
  • <i>N</i>-isobutyl-2-[4-(1,3,4-trioxo-1,3,4,6,11,11a-hexahydro-pyrazino[1,2-<i>b</i>]isoquinolin-2-yl)-phenyl]-acetamide [ No CAS ]
  • 23
  • [ 104-03-0 ]
  • [ 2516-34-9 ]
  • [ 136030-33-6 ]
  • [ 18637-83-7 ]
  • <i>N</i>-cyclobutyl-2-[4-(1,3,4-trioxo-1,3,4,6,11,11a-hexahydro-pyrazino[1,2-<i>b</i>]isoquinolin-2-yl)-phenyl]-acetamide [ No CAS ]
  • 24
  • [ 104-03-0 ]
  • [ 118-31-0 ]
  • [ 101555-63-9 ]
  • [ 18637-83-7 ]
  • <i>N</i>-naphthalen-1-ylmethyl-2-[4-(1,3,4-trioxo-octahydro-pyrido[1,2-<i>a</i>]pyrazin-2-yl)-phenyl]-acetamide [ No CAS ]
  • 25
  • [ 104-03-0 ]
  • [ 118-31-0 ]
  • [ 77128-73-5 ]
  • [ 18637-83-7 ]
  • 2-[4-(3-benzyl-4-methyl-2,5,6-trioxo-piperazin-1-yl)-phenyl]-<i>N</i>-naphthalen-1-ylmethyl-acetamide [ No CAS ]
  • 26
  • [ 104-03-0 ]
  • [ 118-31-0 ]
  • [ 136030-33-6 ]
  • [ 18637-83-7 ]
  • <i>N</i>-naphthalen-1-ylmethyl-2-[4-(1,3,4-trioxo-1,3,4,6,11,11a-hexahydro-pyrazino[1,2-<i>b</i>]isoquinolin-2-yl)-phenyl]-acetamide [ No CAS ]
  • 27
  • [ 104-03-0 ]
  • [ 118-31-0 ]
  • [ 102410-65-1 ]
  • [ 18637-83-7 ]
  • <i>N</i>-naphthalen-1-ylmethyl-2-[4-(2,3,6-trioxo-5-phenyl-piperazin-1-yl)-phenyl]-acetamide [ No CAS ]
  • 28
  • [ 104-03-0 ]
  • [ 118-31-0 ]
  • [ 103478-58-6 ]
  • [ 18637-83-7 ]
  • 2-[4-(3-isopropyl-4-methyl-2,5,6-trioxo-piperazin-1-yl)-phenyl]-<i>N</i>-naphthalen-1-ylmethyl-acetamide [ No CAS ]
  • 29
  • [ 3740-52-1 ]
  • [ 118-31-0 ]
  • [ 136030-33-6 ]
  • [ 18637-83-7 ]
  • <i>N</i>-naphthalen-1-ylmethyl-2-[2-(1,3,4-trioxo-1,3,4,6,11,11a-hexahydro-pyrazino[1,2-<i>b</i>]isoquinolin-2-yl)-phenyl]-acetamide [ No CAS ]
  • 30
  • [ 1877-73-2 ]
  • [ 118-31-0 ]
  • [ 136030-33-6 ]
  • [ 18637-83-7 ]
  • <i>N</i>-naphthalen-1-ylmethyl-2-[3-(1,3,4-trioxo-1,3,4,6,11,11a-hexahydro-pyrazino[1,2-<i>b</i>]isoquinolin-2-yl)-phenyl]-acetamide [ No CAS ]
  • 31
  • [ 5600-62-4 ]
  • [ 118-31-0 ]
  • [ 136030-33-6 ]
  • [ 18637-83-7 ]
  • <i>N</i>-naphthalen-1-ylmethyl-4-[4-(1,3,4-trioxo-1,3,4,6,11,11a-hexahydro-pyrazino[1,2-<i>b</i>]isoquinolin-2-yl)-phenyl]-butyramide [ No CAS ]
  • 32
  • [ 104-03-0 ]
  • [ 136030-33-6 ]
  • [ 18637-83-7 ]
  • [ 107-11-9 ]
  • <i>N</i>-allyl-2-[4-(1,3,4-trioxo-1,3,4,6,11,11a-hexahydro-pyrazino[1,2-<i>b</i>]isoquinolin-2-yl)-phenyl]-acetamide [ No CAS ]
  • 33
  • [ 104-03-0 ]
  • [ 136030-33-6 ]
  • [ 18637-83-7 ]
  • [ 3218-02-8 ]
  • <i>N</i>-cyclohexylmethyl-2-[4-(1,3,4-trioxo-1,3,4,6,11,11a-hexahydro-pyrazino[1,2-<i>b</i>]isoquinolin-2-yl)-phenyl]-acetamide [ No CAS ]
  • 35
  • [ 1211590-53-2 ]
  • [ 18637-83-7 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
67% In tetrahydrofuran at 20℃; for 20h; 20.1 Example 20Preparation of trans-3-(3-biphenylyl)-5-[3'-oxospiro[cyclohexane-1,1'(3H)-isobenzofuran]-4-yl]-1H-pyrazole(1) Preparation of trans-3'-oxospiro[cyclohexane-1,1'(3'H)-isobenzofuran]-4-carboxylic acid imidazolide To a solution of trans-3'-oxospiro[cyclohexane-1,1'(3'H)-isobenzofuran-4-carboxylic acid (1.00 g, 4.06 mmol) in tetrahydrofuran (25 mL) was added N,N'-dicarbonyldiimidazole (858 mg, 4.47 mmol), and the mixture was stirred at room temperature for 20 hours under a nitrogen atmosphere. The resulting solid was collected by filtration, washed with tetrahydrofuran, and dried to obtain the title compound (808 mg, 67 %).
  • 36
  • [ 874279-48-8 ]
  • [ 18637-83-7 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
60% In tetrahydrofuran Inert atmosphere;
In tetrahydrofuran at 20℃; for 16h; 264 To a solution of 4-{4-[2-(4-tert-Butyl-phenyl)-1H-benzoimidazol-4-yl]-piperazin-1-ylmethyl}-N2-pyridin-3-ylmethyl-benzene-1,2-diamine (0.047g, 0.086 mMol) in dry tetrahydrofuran (10 mL) was added 1,1'-oxalyldiimidazole (0.082g, 0.43 mMol) and the solution stirred at room temperature for sixteen hours. The solution was diluted with ethyl acetate (100 mL), washed with water (2×50 mL), brine (50 mL), and the organic layer dried (MgSO4). After filtration the solution was concentrated and purified by RP-HPLC (Method E). 1H NMR (DMSO-d6): δ=12.29 (s, 1H), 9.86 (br s, 1H), 8.74 (s, 1H), 8.52 (d, 1H, J=4.3 Hz), 8.10 (d, 2H, J=8.4 Hz), 7.87 (d, 1H, J=8.0 Hz), 7.59 (d, 2H, J=8.5 Hz), 7.45 (dd, 1H, J=7.9, 4.9 Hz), 7.38 (s, 1H), 7.35 (d, 1H, J=8.6 Hz), 7.29 (d, 1H, J=8.1 Hz), 7.15 (m, 2H), 6.63 (dd, 1H, J=6.8, 1.6 Hz), 5.45 (s, 2H), 4.38 (m, 4H), 3.36-3.02 (m, 6H), 1.34 (s, 9H). LC/MS (Method A), rt=0.94 mins., purity=100%, calculated mass=599, [M+H]+=600, [M-H]-=598.
  • 37
  • [ 18637-83-7 ]
  • [ 460744-15-4 ]
  • [ 460744-45-0 ]
YieldReaction ConditionsOperation in experiment
51% In methanol; N,N-dimethyl-formamide 27 6-(7,8-Dimethoxy-4-oxo-4H-chromen-2-yl)-1,4-dihydro-2,3-quinoxalinedione (Compound 81) EXAMPLE 27 6-(7,8-Dimethoxy-4-oxo-4H-chromen-2-yl)-1,4-dihydro-2,3-quinoxalinedione (Compound 81) To a solution of 2-(3,4-diaminophenyl)-7,8-dimethoxy-4H-chromen-4-one (100 mg, 0.32 mmol) in anhydrous DMF (1 mL), at room temperature, 1,1'-oxalyl-diimidazol (91 mg, 0.48 mmol) is added. and the mixture is stirred for 24 hours. Methanol (5 mL) is added and the suspension is stirred at 50° C. for 30 min. After cooling the yellow solid precipitated is filtered, washed with methanol, ether and dried in vacuum to obtain 6-(7,8-dimethoxy-4-oxo-4H-chromen-2-yl)-1,4-dihydro-2,3-quinoxalinedione as yellowish solid. Yield: 51%. 1H-NMR (400 Mhz, DMSOd6)1 ppm: 2.55 (3H, s), 3.90-4.00 (6H, m), 6.80 (1H, s), 7.20-7.30 (2H, m), 7.70-7.85 (3H, m)
  • 38
  • [ 5807-30-7 ]
  • [ 18637-83-7 ]
  • [ 129823-18-3 ]
YieldReaction ConditionsOperation in experiment
With lithium hydroxide In tetrahydrofuran; dichloromethane; water 7.ii (ii) (ii) 5-[(3,4-Dichlorophenyl)acetyl]-4,5,6,7-tetrahydrofuro[3,2-c]pyridine-4-methanol A solution of 3,4-dichlorophenyl acetic acid (4.6 g) in dry dichloromethane (100 ml) was treated with 1,1'-dicarbonyldiimidazole (3.6 g). The mixture was stirred at ambient temperature for 30 min. A solution of the product of stage (i) (1.13 g) in dry dichloromethane (20 ml) was added and the mixture was stirred at ambient temperature for 20 h. The mixture was washed with aqueous sodium carbonate solution (1M; 2*100 ml), dried (Na2 SO4) and evaporated in vacuo. The residue was dissolved in tetrahydrofuran (50 ml) and a solution of lithium hydroxide (0.575 g) in water (40 ml) was added. The mixture was vigorously stirred at ambient temperature for 80 min. The organic solvent was removed in vacuo and the aqueous residue was extracted with dichloromethane (50 ml). The organic extract was dried (Na2 SO4) and evaporated in vacuo to give a solid residue which was crystallized from methylacetate and hexane to give the title compound as a pale yellow solid (1.81 g) m.p. 155°-6°.
  • 39
  • [ CAS Unavailable ]
  • [ 18637-83-7 ]
  • [ 58-85-5 ]
  • [ 101187-30-8 ]
YieldReaction ConditionsOperation in experiment
With sodium hydrogencarbonate; citric acid In hexane; water; ethyl acetate; N,N-dimethyl-formamide; butan-1-ol 4.B B. B. Synthesis of (N-biotinyl, N'-t-butyloxycarbonyl)-4,9-dioxa-1,12-dodecanediamine (Compound IX) A total of 2.055 g d-biotin was suspended in 34 ml of dry DMF and the suspension was heated to 80° C., at which point the biotin had all dissolved. To this solution was added 1.38 g of 1,1'-biscarbonyldiimidazole, and stirring and heating were continued for about 15 minutes until gas evolution ceased. The flask was allowed to cool for one hour and stirring was continued as a precipitate formed. To the resulting suspension was added 2.75 g of Compound VIII and stirring was continued for 16 hours. All material went into solution. The solvent was removed under vacuum and the residue was dissolved in 100 ml n-butanol and washed two times with 50 ml of 0.5N citric acid, 50 ml of saturated sodium chloride, 50 ml of 5% sodium bicarbonate and 50 ml of water. The alcohol was removed under vacuum and the residue was dissolved in about 50 ml of hot ethyl acetate. The solution was poured into 800 ml of hexane and the precipitate was removed by filtration and dried to yield a white powder weighing 3.755 g (84% yield). Correct elemental analyses of Compound IX were obtained for C, H, N as the monohydrate of the product.
  • 40
  • [ 80727-59-9 ]
  • [ 18637-83-7 ]
  • [ 80727-60-2 ]
YieldReaction ConditionsOperation in experiment
In <i>N</i>-methyl-acetamide 1 E. E-1. 1,3-Dihydro-5-(4-pyridinyl)-2H-imidazo[4,5-b]-pyridin-2-one--To a warm (45° C.) solution of 11.2 g. of 2,3-diamino-6-(4-pyridinyl)pyridine in 100 ml. of dimethylformamide was added with stirring 10.5 g. of 1,1'-dicarbonyldiimidazole. Solid began to separate within a few minutes. The reaction mixture was stirred with no external heating for about 40 minutes (temperature of 45° C. with no change in appearance after the first ten minutes) and then heated to 80° C. (no change in appearance). The separated solid was collected, washed and triturated with ethanol and dried at 70° C. in vacuo to yield 11.3 g. of 1,3-dihydro-5-(4-pyridinyl)-2H-imidazo[4,5-b]pyridin-2-one, m.p. >300° C.
  • 41
  • [ 58012-37-6 ]
  • [ 18637-83-7 ]
  • [ 58012-45-6 ]
YieldReaction ConditionsOperation in experiment
In tetrahydrofuran 10 Preparation of 8-chloro-3-dibenzofuranacetamide EXAMPLE 10 Preparation of 8-chloro-3-dibenzofuranacetamide A solution of 9.45 g. of 8-chloro-3-dibenzofuranacetic acid in 225 ml. of tetrahydrofuran was treated with 6.01 g. of 98% 1,1'-dicarbonyldiimidazole and stirred overnight (16 hours) at room temperature under an atmosphere of nitrogen. Ammonia was passed into the resultant suspension for 3 hours and stirring continued for an additional 1.5 hours. The solid was removed by filtration and washed with tetrahydrofuran and ether to give 8.14 g. of 8-chloro-3-dibenzofuran-acetamide, having a melting point of 258°-263°. A sample crystallized from aqueous methanol and sublimed at 234°/0.1 mm. of mercury melted at 265.5°-266.5°(in vacuo).
  • 42
  • [ 689294-43-7 ]
  • [ 18637-83-7 ]
  • [ 117499-16-8 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
Stage #1: 1-methyl-N-5-trityl-1H-pyrazole-4,5-diamine; 1,1'-oxalyldiimidazole In DMF (N,N-dimethyl-formamide) at 0℃; for 1h; Stage #2: bis(2-tert-butyloxycarbonylaminoethyl)amine In DMF (N,N-dimethyl-formamide) at 20℃; for 240h; 65 To a solusion of 1, 1'-oxalyldiimidazole (1.52 g) in N, N-dimethylformamide (16 ml) was added L-METHYL-N5- TRITYL-LH-PYRAZOLE-4, 5-DIAMINE (1.42 g) under ice- cooling, and the mixture was stirred at room temperature for 1 hour. To the reaction mixture was added a solution of di-tert-butyl [iminobis (2RU- ethanediyl) ] biscarbamate (4.55 g) in N, N- dimethylformamide (4 ml) under ice-cooling, and the mixture was stirred at room temperature for 1 day and then allowed to stand at room temperature for 9 days. To the reaction mixture were added ethyl acetate (50 ml) and methylene chloride (20 ml). The resulting precipitate was collected by filtration and. dried in vacuo to give di-tert-butyl [ ( {2- [I-METHYL-5- (TRITYLAMINO)-LH-PYRAZOL-4-YL]-2- OXOACETYL} IMINO) bis (2, 1-ethanediyl)] biscarbamate (1.79 g) as a solid. The mother liquor was washed successively with water, 5% aqueous citric acid solution and brine. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The crystalline residue was washed with a mixed solvent of methylene chloride and diethyl ether, dried in vacuo and combined with the former solid to give di-tert-butyl [ ( {2- [L-METHYL-5- (TRITYLAMINO)-LH-PYRAZOL-4-YLL-2- oxoacetyl}imino)bis(2,1-ethanediyl)]biscarbamate (2.44 g). 1H-NMR (CDCl3) 8 1.37 (9H, S), 1.45 (9H, s), 2.97 (3H, S), 3.2-3. 4 (4H, M), 3.4-3. 6 (2H, m), 3.78 (2H, T, J = 6.2 Hz), 4.53 (1H, brs), 5.09 (1H, br), 5.34 (1H, br), 7.1- 7.4 (15H, M), 7.49 (1H, s), 8.13 (1H, brs)
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