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Chemical Structure| 187163-72-0 Chemical Structure| 187163-72-0

Structure of 187163-72-0

Chemical Structure| 187163-72-0

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Product Details of [ 187163-72-0 ]

CAS No. :187163-72-0
Formula : C12H19N3O2
M.W : 237.30
SMILES Code : O=C(OC(C)(C)C)NC1=NC(C)=C(CN)C=C1
MDL No. :MFCD09258817

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Application In Synthesis of [ 187163-72-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 187163-72-0 ]

[ 187163-72-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 37718-11-9 ]
  • [ 187163-72-0 ]
  • [ 1357957-53-9 ]
YieldReaction ConditionsOperation in experiment
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0℃; for 0.5h; c)tert-butyl (5-((1H-pyrazole-4-carboxamido)methyl)-4,6-dimethylpyridin-2-yl)carbamateThe starting material ethyl pyrazole-4-carboxylate was saponified in analogy to Example 157, Step a), To a solution of the free acid (1 g, 5.86 mmol) in DMF (40 ml) were added DIPEA (4.10 ml, 23.46 mmol) and tert-butyl (5-(aminomethyl)-6-methylpyridin-2-yl)carbamate (1.531 g, 6.45 mmol).At 0° C., propylphosphonic anhydride (50percent in DMF, 3.42 ml, 5.86 mmol) was added dropwise.Reaction mixture was stirred for 30 min at 0° C., then diluted with ethyl acetate and water.Phases were separated and organic layer was washed with NaHCO3 sat. solution and brine.Organic layer was dried over sodium sulfate, filtered and evaporated to afford the crude material, which was purified by silicagel chromatography (DCM/MeOH from 100/0 to 9/1 in 30 min) to afford the title compound. HPLC (Method G) Rt=1.209 min, MS (Method V) [M+H]+=332.3.
 

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