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Chemical Structure| 18718-79-1 Chemical Structure| 18718-79-1

Structure of 18718-79-1

Chemical Structure| 18718-79-1

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Product Details of [ 18718-79-1 ]

CAS No. :18718-79-1
Formula : C11H11NO2
M.W : 189.21
SMILES Code : CC1=C(CO)C(=NO1)C1=CC=CC=C1
MDL No. :MFCD02677724

Safety of [ 18718-79-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 18718-79-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 18718-79-1 ]

[ 18718-79-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 18718-79-1 ]
  • [ 52867-42-2 ]
  • [ 1254966-20-5 ]
YieldReaction ConditionsOperation in experiment
31% With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 5 - 20℃;Inert atmosphere; ) 2-Methyl-5 -(5 -methyl-3 -phenyl- isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl esterTo a stirred solution of 5-hydroxy-2H-pyrazole-3-carboxylic acid methyl ester (200 mg, 1.28 mmol) and (5 -methyl-3 -phenyl-4-isoxazolyl)methanol (260 mg, 1.37 mmol) in THF (10 mL) at 5 0C under argon was added triphenylphosphine (437 mg, 1.67 mmol), then diethyl azodicarboxylate (290 mg, 1.67 mmol) was added dropwise. The reaction mixture was warmed to room temperature for 3 h. The reaction mixture was then evaporated and purification by chromatography (silica, heptane:ethyl acetate = 1 :1 to 6.5:3.5) afforded the title compound (128 mg, 31%) as a colorless oil. MS: m/e = 328.3 [M+H]+.
 

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