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CAS No. : | 187872-11-3 | MDL No. : | MFCD11044062 |
Formula : | C10H9BrO2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | UOPZFPWKIZTDRV-UHFFFAOYSA-N |
M.W : | 241.08 | Pubchem ID : | 22278718 |
Synonyms : |
|
Signal Word: | Warning | Class: | |
Precautionary Statements: | P280-P305+P351+P338 | UN#: | |
Hazard Statements: | H302 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
83% | With aluminum (III) chloride In toluene for 0.25 h; Heating / reflux | 46.7 g (0.35 mol) of aluminium chloride are added portionwise to a solution of 28.3 g (0.117 mol) of 5-BROMO-6-METHOXYINDAN-1-ONE in 500 ml of toluene. The reaction mixture is heated at reflux for 15 minutes and is then poured into water and the phases are separated by settling (sparingly soluble product). The suspended solid is filtered off and the solvents are evaporated off. The solid residue is purified by flash chromatography (98/2 CH2CI2/MEOH), and 22 g of solid are obtained (83percent); m. p. = 210°C. 1H NMR-CHCI3-6 (ppm): 2.69 (2H, m); 3.06 (2H, m); 5.73 (1 H, s); 7.33 (1 H, s); 7.63 (1H, s). |
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