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Chemical Structure| 187872-11-3 Chemical Structure| 187872-11-3

Structure of 187872-11-3

Chemical Structure| 187872-11-3

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Product Details of [ 187872-11-3 ]

CAS No. :187872-11-3
Formula : C10H9BrO2
M.W : 241.08
SMILES Code : O=C1CCC2=C1C=C(OC)C(Br)=C2
MDL No. :MFCD11044062
InChI Key :UOPZFPWKIZTDRV-UHFFFAOYSA-N
Pubchem ID :22278718

Safety of [ 187872-11-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 187872-11-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 187872-11-3 ]

[ 187872-11-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 69888-90-0 ]
  • [ 187872-11-3 ]
  • [ 83802-71-5 ]
YieldReaction ConditionsOperation in experiment
94% Reference Example 23 5-Fluoro-6-methoxy-1-indanone Starting with 3-(3-fluoro-4-methoxyphenyl)propionic acid, the title compound was synthesised in otherwise the same manner as Reference Example 11 (yield 94percent). m.p. 152-154° C. NMR(CDCl3) delta: 2.70(2H,t,J=5.5 Hz), 3.07(2H,t,J=5.5 Hz), 3.91(3H,s), 7.17(1H,d,J=10.3 Hz), 7.29(1H,d,J=10.3 Hz). Elemental analysis for C10 H9 FO2: Calcd.: C, 66.66; H, 5.03. Found: C, 66.85; H, 4.97.
  • 2
  • [ 187872-11-3 ]
  • [ 503309-10-2 ]
  • C17H12F4O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
To a solution of 203 (100 mg, 0.414 mmol) and <strong>[503309-10-2](2-fluoro-4-(trifluoromethoxy)phenyl)boronic acid</strong> (101.8 mg, 0.456 mmol) in acetonitrile was added cesium carbonate (272.1 mg, 0.829 mmol). The reaction was degassed and purged with nitrogen for 10 min. Pd(dppf)Cl2 (16.9 mg, 0.020 mmol) was added to the reaction, which was then degassed and purged with nitrogen for another 10 min. The reaction was heated to 90 C. under sealed condition overnight, then allowed to cool to rt, and diluted with chloroform. The organic layer was filtered through celite plug and concentrated to get the crude 214, which was purified through flash chromatography by using 100-200 mesh silica gel. The compound was eluted in 5% ethyl acetate in hexane as half white solid 214.
 

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Technical Information

• Alkyl Halide Occurrence • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Bucherer-Bergs Reaction • Clemmensen Reduction • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Fischer Indole Synthesis • Friedel-Crafts Reaction • General Reactivity • Grignard Reaction • Henry Nitroaldol Reaction • Hiyama Cross-Coupling Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Hydrogenolysis of Benzyl Ether • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Lawesson's Reagent • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Nomenclature of Ethers • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Alkylbenzene • Preparation of Amines • Preparation of Ethers • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Dihalides • Reactions of Ethers • Reformatsky Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Stille Coupling • Stobbe Condensation • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • Ugi Reaction • Vilsmeier-Haack Reaction • Wittig Reaction • Wolff-Kishner Reduction

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