188027-95-4|2,7-Dichloroxanthene-9-carboxylic acid| Ambeed

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CAS No. :	188027-95-4
Formula :	C₁₄H₈Cl₂O₃
M.W :	295.11
SMILES Code :	O=C(C1C2=C(OC3=C1C=C(Cl)C=C3)C=CC(Cl)=C2)O
MDL No. :	MFCD15142806
InChI Key :	OCUBZGSJBOWQLF-UHFFFAOYSA-N
Pubchem ID :	23283109

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P233-P260-P261-P264-P271-P280-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501

Yield	Reaction Conditions	Operation in experiment
6.98 g (55.2%)	With hydrogenchloride; N-chloro-succinimide; In water; acetic acid;	EXAMPLE 8 2,7-Dichloroxanthene-9-carboxylic Acid: To a suspension of 10 g of xanthene-9-carboxylic acid and 14 g of N-chlorosuccinimide in 80 mL of acetic acid was added with stirring dropwise 2.0 mL of conc. HCl over a period of 5 minutes. The mixture was stirred at room temperature for 12 hours and quenched by the addition of 150 mL of water. The precipitated solid was removed by filtration, rinsed with water, and dried in air to give 12.6 g (100%) of the crude carboxylic acid as a white solid. Recrystallization from MeOH--EtOAc (2:1) gave 6.98 g (55.2%) of the pure 2,7-dichloroxanthene-9-carboxylic acid as colorless small needles, m.p. 273-275 C. (dec.); IR (KBr): 2970 (b, OH), 1695 (C=O) cm-1; 1 H NMR (DMSO-d6): δ 5.01 s, 1H, CH), 7.05-7.50 (m, 6H, aryl). Anal. Calcd for C14 H8 Cl2 O3: C, 56.98; H, 2.73. Found: C, 57.05; H, 2.74.
	With hydrogenchloride; N-chloro-succinimide; acetic acid; In water; at 20℃; for 48h;	Intermediate 422,7-dichloro-9H-xanthene-9-carboxylic acidAcetic acid (80 ml.) and N-chlorosuccinimide (14.7 g, 110 mmols) were added to xanthene-9-carboxylic acid (10.0 g, 44 mmols). Hydrochloric acid (2 ml.) was added dropwise to the mixture at room temperature and it was stirred under these conditions for EPO <DP n="77"/>48 hours. Water was added (150 mL) and the precipitate was filtered. The product obtained was used without further purification in the synthesis of example 54.

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P337 + P313	IF eye irritation persists: Get medical advice/attention.
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P370 + P378	In case of fire:
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Disposal
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P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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CAS No.: 188027-95-4

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CAS No.: 188027-95-4

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[ 188027-95-4 ] Synthesis Path-Downstream 1~4

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed