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[ CAS No. 188582-62-9 ]

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2D
Chemical Structure| 188582-62-9
Chemical Structure| 188582-62-9
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Product Details of [ 188582-62-9 ]

CAS No. :188582-62-9MDL No. :MFCD00143265
Formula : C7H6BrFO Boiling Point : -
Linear Structure Formula :-InChI Key :N/A
M.W :205.02Pubchem ID :-
Synonyms :

Computed Properties of [ 188582-62-9 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 188582-62-9 ]

Signal Word:WarningClass:N/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 188582-62-9 ]

  • Upstream synthesis route of [ 188582-62-9 ]
  • Downstream synthetic route of [ 188582-62-9 ]

[ 188582-62-9 ] Synthesis Path-Upstream   1~6

  • 1
  • [ 188582-62-9 ]
  • [ 128577-47-9 ]
Reference: [1] European Journal of Medicinal Chemistry, 2018, vol. 150, p. 506 - 524
  • 2
  • [ 188582-62-9 ]
  • [ 76283-09-5 ]
YieldReaction ConditionsOperation in experiment
91% at 100℃; for 0.166667 h; The above compound (7.00 g, 34.1 mmol) was dissolved into 48percent hydrobromic acid (35 mL), and the resultant was caused to react at 100° for 10 minutes. After the end of the reaction, the resultant was neutralized with potassium carbonate. Thereafier, extraction with ethyl acetate was carried out, and this extraction layer was washed with water and a saturated saline solution, then dried over anhydrous magnesium sulfate, and concentrated under a reduced pressure to yield a compound (8.35 g, 91percent). 1H-NMR (CDC13): 4.46 (s, 2H, HnCH2), 7.25-7.29 (m, 3H, Ar).
Reference: [1] Patent: US2017/15684, 2017, A1, . Location in patent: Paragraph 0144; 0145; 0146
  • 3
  • [ 188582-62-9 ]
  • [ 134057-95-7 ]
Reference: [1] ChemMedChem, 2018, vol. 13, # 9, p. 931 - 943
  • 4
  • [ 188582-62-9 ]
  • [ 57848-46-1 ]
Reference: [1] Advanced Synthesis and Catalysis, 2014, vol. 356, # 8, p. 1741 - 1746
  • 5
  • [ 188582-62-9 ]
  • [ 881189-74-8 ]
Reference: [1] ChemMedChem, 2018, vol. 13, # 9, p. 931 - 943
  • 6
  • [ 73183-34-3 ]
  • [ 188582-62-9 ]
  • [ 1082066-29-2 ]
YieldReaction ConditionsOperation in experiment
48% With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane at 90℃; Inert atmosphere 3.1.1.
Preparation of (2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol (934-2)
At 90° C. under N2 atmosphere, to a stirred solution of 4-bromo-2-fluorophenylmethanol (500 mg, 2.44 mmol) in dioxane (5 mL) were added B2Pin2 (929 mg, 3.66 mmol), Pd(dppf)Cl2.DCM (198 mg, 0.24 mmol) and KOAc (717 mg, 7.32 mmol).
After being stirred at 90° C. overnight, the reaction mixture was cooled down to room temperature and partitioned between EA and H2O.
The layers were separated and the organic layer was washed with brine, dried over Na2SO4.
Solvents were removed under vacuum and the residue was purified by flash chromatography (silica gel, 0˜20 ethyl acetate in petroleum ether) to provide (2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol (934-2) (300 mg, 48percent) as a yellow oil.
Reference: [1] Patent: US2018/194762, 2018, A1, . Location in patent: Paragraph 0740-0741
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 18, p. 4984 - 4995
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