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[ CAS No. 1891-90-3 ] {[proInfo.proName]}

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3d Animation Molecule Structure of 1891-90-3
Chemical Structure| 1891-90-3
Chemical Structure| 1891-90-3
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Product Details of [ 1891-90-3 ]

CAS No. :1891-90-3 MDL No. :MFCD00007998
Formula : C8H6F3NO Boiling Point : -
Linear Structure Formula :- InChI Key :WEJHBEDHLLBJFW-UHFFFAOYSA-N
M.W :189.14 Pubchem ID :74684
Synonyms :

Calculated chemistry of [ 1891-90-3 ]

Physicochemical Properties

Num. heavy atoms : 13
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.12
Num. rotatable bonds : 2
Num. H-bond acceptors : 4.0
Num. H-bond donors : 1.0
Molar Refractivity : 39.54
TPSA : 43.09 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.24 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.35
Log Po/w (XLOGP3) : 1.71
Log Po/w (WLOGP) : 2.96
Log Po/w (MLOGP) : 2.27
Log Po/w (SILICOS-IT) : 2.0
Consensus Log Po/w : 2.06

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.3
Solubility : 0.949 mg/ml ; 0.00502 mol/l
Class : Soluble
Log S (Ali) : -2.23
Solubility : 1.11 mg/ml ; 0.00588 mol/l
Class : Soluble
Log S (SILICOS-IT) : -2.88
Solubility : 0.252 mg/ml ; 0.00133 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.02

Safety of [ 1891-90-3 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1891-90-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1891-90-3 ]
  • Downstream synthetic route of [ 1891-90-3 ]

[ 1891-90-3 ] Synthesis Path-Upstream   1~39

  • 1
  • [ 329-15-7 ]
  • [ 1891-90-3 ]
YieldReaction ConditionsOperation in experiment
95% With ammonia In water at 20℃; for 3 h; Synthesis of compound C; Aqueous ammonia (2 ml) was added to 4-(trifluoromethyl)-benzoyl chloride (417 mg, 2 mmol) at room temperature with stirring, and the reaction was allowed to proceed for 3 hours. The completion of the reaction was confirmed using a TLC plate (ethyl acetate:hexane = 1:2), and the reaction product was introduced into 10 ml of water, followed by extraction with ethyl acetate (10 ml .x. 3). The ethyl acetate layer was washed with water (10 ml .x. 2) and with saturated saline (10 ml), dried over magnesium sulfate, and then filtered to obtain a crude product via removal of a solvent by distillation under reduced pressure (355 mg, 2.0 mmol). The resultant was recrystallized with a mixed solvent of ethyl acetate/hexane to obtain compound C (white, needle-like crystal, 359 mg). Yield: 95percent; m.p.: 186.5-187.5°C 1H-NMR (300 MHz, DMSO-d6) δ: 7.63, 8.19 (both br s, both 1H, NH or OH), 8.06 (d, 2H, J = 8.0 Hz, Ar-H), 7.84 (d, 2H, J = 8.0 Hz, Ar-H)
Reference: [1] Organic Process Research and Development, 2007, vol. 11, # 6, p. 1010 - 1014
[2] Patent: EP2070908, 2009, A1, . Location in patent: Page/Page column 9; 13
[3] Journal of Medicinal Chemistry, 2008, vol. 51, # 8, p. 2400 - 2411
[4] Synthetic Communications, 2010, vol. 40, # 23, p. 3538 - 3543
[5] Ukrainskii Khimicheskii Zhurnal (Russian Edition), 1957, vol. 23, p. 634[6] Chem.Abstr., 1958, p. 9979
[7] Journal of Organic Chemistry, 2016, vol. 81, # 5, p. 2166 - 2173
[8] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 10, p. 2544 - 2546
[9] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 14, p. 3263 - 3270
[10] Organic Letters, 2017, vol. 19, # 13, p. 3596 - 3599
  • 2
  • [ 201230-82-2 ]
  • [ 402-43-7 ]
  • [ 1891-90-3 ]
Reference: [1] Organic Letters, 2011, vol. 13, # 16, p. 4454 - 4457
[2] Advanced Synthesis and Catalysis, 2012, vol. 354, # 16, p. 3065 - 3070
[3] Journal of Organic Chemistry, 2001, vol. 66, # 12, p. 4311 - 4315
[4] Chemistry - A European Journal, 2010, vol. 16, # 32, p. 9750 - 9753
[5] Chemistry - An Asian Journal, 2010, vol. 5, # 10, p. 2168 - 2172
[6] Tetrahedron Letters, 2013, vol. 54, # 24, p. 3040 - 3042
  • 3
  • [ 455-19-6 ]
  • [ 1891-90-3 ]
YieldReaction ConditionsOperation in experiment
54%
Stage #1: at -33℃; for 1 h; Inert atmosphere
Stage #2: at -33℃; for 1 h; Inert atmosphere; Reflux
General procedure: Under an argon atmosphere, liquid NH3 (25 mL) was condensedin a two-neck round-bottom flask immersed in a dry ice coolingbath and equipped with a dry ice reflux condenser. Aldehyde(7.34 mmol) was added, and the resulting solution (or suspension)was stirred for 1 h. KMnO4 (7.34 mmol, 1.16 g) was added,the cooling bath was removed, and the reaction mixture wasstirred for another hour with gentle reflux of NH3. Na2SO3 (22.0mmol, 2.78 g) was added, the reflux condenser was removed,and the NH3 was allowed to evaporate spontaneously. The darkbrownresidue was treated with 6 M HCl (30 mL), and theresulting precipitate was filtered, washed with H2O (100 mL)and sat. aq NaHCO3 (20 mL). All products were recrystallizedfrom EtOH.
54%
Stage #1: at -33℃; for 1 h; Inert atmosphere
Stage #2: for 1 h; Inert atmosphere; Reflux
General procedure: Under an argon atmosphere, liquid NH3 (25 mL) was condensedin a two-neck round-bottom flask immersed in a dry ice coolingbath and equipped with a dry ice reflux condenser. Aldehyde (7.34 mmol) was added, and the resulting solution (or suspension)was stirred for 1 h. KMnO4 (7.34 mmol, 1.16 g) was added,the cooling bath was removed, and the reaction mixture wasstirred for another hour with gentle reflux of NH3. Na2SO3 (22.0mmol, 2.78 g) was added, the reflux condenser was removed,and the NH3 was allowed to evaporate spontaneously. The darkbrownresidue was treated with 6 M HCl (30 mL), and theresulting precipitate was filtered, washed with H2O (100 mL)and sat. aq NaHCO3 (20 mL). All products were recrystallizedfrom EtOH.
Reference: [1] Journal of Chemical Research, 2012, vol. 36, # 8, p. 460 - 462
[2] RSC Advances, 2015, vol. 5, # 55, p. 44524 - 44529
[3] RSC Advances, 2016, vol. 6, # 43, p. 37093 - 37098
[4] Synlett, 2014, vol. 25, # 9,
[5] Synlett, 2015, vol. 26, # 1, p. 84 - 86
[6] Organic and Biomolecular Chemistry, 2014, vol. 12, # 3, p. 414 - 417
[7] Journal of Organic Chemistry, 2012, vol. 77, # 18, p. 8007 - 8015,9
[8] Journal of Organic Chemistry, 2012, vol. 77, # 18, p. 8007 - 8015
[9] Organic Letters, 2007, vol. 9, # 1, p. 73 - 75
  • 4
  • [ 455-18-5 ]
  • [ 1891-90-3 ]
YieldReaction ConditionsOperation in experiment
95% at 70℃; for 24 h; Schlenk technique; Sealed tube General procedure: To an oven dried Schlenk carousel tube containing the appropriate nitrile (1 mmol) was added palladium acetate (11 mg, 5 molpercent), 2,2'-bipyridine (7.8 mg, 5 molpercent) and water (2 mL, 0.5 M). The tube was then sealed and the reaction mixture heated at 70 °C for 24 hours. After being allowed to cool to room temperature, the reaction mixture was diluted with methanol (5 mL) and the solvent removed in vacuo on a rotary evaporator whilst azeotroping with toluene. Where the reaction had gone to quantitative conversion or the starting nitrile was volatile, the crude reaction mixture was passed through a short plug of silica to remove the catalyst (eluting with DCM/MeOH, 95:5). Otherwise, the primary amide products were purified by column chromatography (eluting with DCM/MeOH, 95:5, unless otherwise stated).
90% for 1 h; Schlenk technique; Reflux; Green chemistry General procedure: In a Schlenk-tube of approximately 12 mL volume, 0.05 mmol Ru(II)-precursor (1, 2 or RuCl3×3H2O) and 0.15 mmol phosphine ligand were dissolved in 3 mL water. This was followed by addition of 1 mmol nitrile. The tube was equipped with a reflux condenser and then immersed to an oil bath of 108-110 °C temperature. The reaction mixture was stirred magnetically under reflux on air. In case of aliphatic nitriles heavy-walled closed reaction tubes of 5 mL volume were used. At the end of the reaction (or at other appropriate reaction times) 50 μL samples were withdrawn from the hot reaction mixture and these were extracted with 3×2 mL dichloromethane. A 1.5 mL portion of the combined organic phases was passed through a plug of unhydrous MgSO4 and the resulting clear solution was analysed by gas chromatography.
77% With Acetaldehyde oxime; [(eta.(5)-pentamethylcyclopentadienyl)Rh(H2O)3](OTf)2 In water at 50℃; for 6 h; Schlenk technique A solution of 4- (trifluoromethyl) benzonitrile (171 mg, 1 mmol), [Cp * Rh (H2O)3] [OTf]2(3.0 mg, 0.005 mmol, 0.5 molpercent), acetaldehyde oxime (65 mg, 1.1 mmol) and water (1 ml) were successively added to a 25 ml Schlenk reaction flask.The reaction mixture was reacted at 50 ° C for 6 hours, then cooled to room temperature, and the water was removed by rotary evaporation to remove the title product. The yield was 77percent
77% With C20H24ClNO2Ru; sodium hydroxide In isopropyl alcohol at 79.84℃; for 4 h; Inert atmosphere; Schlenk technique General procedure: To a stirred solution of half-sandwich ruthenium complex (0.25molpercent) in 2.0mL of isopropanol were added NaOH (0.3mmol) and benzonitrile (0.3mmol) followed by stirring for 4h at 353K. After completion of the reaction (monitored by TLC), the resulting solution was evaporated to dryness at reduced pressure. The crude products loaded directly onto a column of silica gel and purified by column chromatography to yield the corresponding amides [15].
33% With oxygen; copper; ammonium chloride In N,N-dimethyl-formamide at 120℃; Sealed tube In the reaction vessel was added 25molpercent Cu, the reaction tube was evacuated, filled with oxygen,0.2 mmol of 4-trifluoromethylbenzonitrile, 0.5 mmol of ammonium chloride and 2 ml of N, N-dimethylformamide were added in an atmosphere of oxygen, the reaction vessel was sealed, and reacted at 120 ° C,After the reaction was completed, it was washed with water, extracted with chloroform, dried and evaporated under reduced pressure to remove the solvent. The crude product was separated by column chromatography to give the desired product in a yield of 33percent.
0.3 g With dihydrogen peroxide; potassium carbonate In dimethyl sulfoxide at 0 - 20℃; for 1 h; To a cold solution of 4-(trifluoromethyl)benzonitrile (0.500 g, 2.92 mmol) in DMSO (6.0 mL) was added H202 (50percent) (5 mL) at 0°C, followed by portion -wise addition of K2CO3 (0.121 g, 0.87 mmol). The reaction mass was allowed to attain RT and stirred for 1 h. The reaction mass was quenched in ice water and extracted with DCM and concentrated to afford 0.300 g of product. 1H NMR (400 MHz, DMSO d6): δ 7.60 (br s, 1H), 7.82 (d, J= 7.5 Hz, 2H), 8.05 (d, J = 6.6 Hz, 2H), 8.17 (br s, 1H); MS (m/z): 190.11 (M+H+).

Reference: [1] Dalton Transactions, 2015, vol. 44, # 27, p. 12082 - 12085
[2] Applied Organometallic Chemistry, 2014, vol. 28, # 12, p. 900 - 907
[3] Catalysis Science and Technology, 2015, vol. 5, # 3, p. 1606 - 1622
[4] Organic Letters, 2009, vol. 11, # 24, p. 5598 - 5601
[5] Organic Syntheses, 2012, vol. 89, p. 66 - 72
[6] Tetrahedron Letters, 2017, vol. 58, # 43, p. 4090 - 4093
[7] Chemical Communications, 2016, vol. 52, # 7, p. 1436 - 1438
[8] Tetrahedron Letters, 2014, vol. 55, # 26, p. 3615 - 3617
[9] Catalysis Science and Technology, 2015, vol. 5, # 5, p. 2865 - 2868
[10] Advanced Synthesis and Catalysis, 2016, vol. 358, # 18, p. 2889 - 2894
[11] European Journal of Organic Chemistry, 2017, vol. 2017, # 14, p. 1870 - 1875
[12] Catalysis Science and Technology, 2018, vol. 8, # 10, p. 2606 - 2616
[13] New Journal of Chemistry, 2013, vol. 37, # 10, p. 2987 - 2990
[14] Patent: CN104744288, 2017, B, . Location in patent: Paragraph 0056; 0057; 0058; 0059
[15] Polyhedron, 2017, vol. 138, p. 1 - 6
[16] Patent: CN106478442, 2017, A, . Location in patent: Paragraph 0058; 0059; 0060
[17] Tetrahedron Letters, 2010, vol. 51, # 13, p. 1639 - 1641
[18] Organometallics, 2013, vol. 32, # 3, p. 824 - 834
[19] Patent: WO2013/186692, 2013, A1, . Location in patent: Page/Page column 123
[20] Chemical Communications, 2014, vol. 50, # 61, p. 8303 - 8305
[21] Catalysis Science and Technology, 2015, vol. 5, # 3, p. 1953 - 1960
[22] Patent: CN105820061, 2016, A, . Location in patent: Paragraph 0140-0143
[23] ACS Catalysis, 2014, vol. 4, # 9, p. 3096 - 3104
  • 5
  • [ 15226-74-1 ]
  • [ 402-43-7 ]
  • [ 1891-90-3 ]
YieldReaction ConditionsOperation in experiment
92% With 1H-imidazole; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; ammonium chloride; N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 90℃; for 3 h; Sealed tube General procedure: To a stirred solution of aryl halide (Br/I) (1 mmol) in dry dioxane in a 25 mL sealed tube, was added Pd(OAc)2 (5 molpercent), dppf (6 mol percent), DIPEA (2 mmol), imidazole (0.25 mmol), ammonium chloride (2 mmol) and then Co2(CO)8 (0.3 mmol). The seal tube was closed immediately and stirred at 90 °C for 3h. After the reaction time the reaction mixture was cooled to room temperature. The reaction mixture was filtered through celite pad and washed with dioxane, the filtrate was concentrated under reduced pressure and the residue obtained was purified by column chromatography.
Reference: [1] Tetrahedron Letters, 2015, vol. 56, # 34, p. 4864 - 4867
  • 6
  • [ 1448887-34-0 ]
  • [ 1891-90-3 ]
YieldReaction ConditionsOperation in experiment
90% With ammonium hydroxide In water at 100℃; for 8.5 h; Reflux To β-ketodithioester 1 (1.0 mmol), 10 mL of 25percent aq. ammonia solution was added and the reaction mixture was refluxed at 100 °C with constant stirring for the stipulated period of time. After completion of the reaction (monitored by TLC), water (20 mL) was added to the reaction mixture followed by extraction with ethyl acetate (2 × 10 mL). The combined organic layer was dried over anhydrous Na2SO4 and evaporated under vacuum. The crude residue was purified by column chromatography over silica gel using ethyl acetate/hexane as eluent to afford pure compound. Most of the synthesized isothiazoles 3 were previously reported by our group and the recorded spectral data match with the reported one.2
Reference: [1] Tetrahedron Letters, 2017, vol. 58, # 25, p. 2512 - 2516
  • 7
  • [ 349-95-1 ]
  • [ 1891-90-3 ]
Reference: [1] New Journal of Chemistry, 2015, vol. 39, # 2, p. 921 - 930
[2] Green Chemistry, 2013, vol. 15, # 7, p. 1956 - 1961
[3] Catalysis Communications, 2012, vol. 26, p. 48 - 53
[4] Advanced Synthesis and Catalysis, 2010, vol. 352, # 14-15, p. 2588 - 2598
[5] Organic Letters, 2007, vol. 9, # 1, p. 73 - 75
[6] Catalysis Science and Technology, 2013, vol. 3, # 2, p. 318 - 327
[7] ACS Catalysis, 2018, vol. 8, # 11, p. 9936 - 9944
  • 8
  • [ 15226-74-1 ]
  • [ 455-13-0 ]
  • [ 1891-90-3 ]
YieldReaction ConditionsOperation in experiment
79% With 1H-imidazole; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; ammonium chloride; N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 90℃; for 3 h; Sealed tube General procedure: To a stirred solution of aryl halide (Br/I) (1 mmol) in dry dioxane in a 25 mL sealed tube, was added Pd(OAc)2 (5 molpercent), dppf (6 mol percent), DIPEA (2 mmol), imidazole (0.25 mmol), ammonium chloride (2 mmol) and then Co2(CO)8 (0.3 mmol). The seal tube was closed immediately and stirred at 90 °C for 3h. After the reaction time the reaction mixture was cooled to room temperature. The reaction mixture was filtered through celite pad and washed with dioxane, the filtrate was concentrated under reduced pressure and the residue obtained was purified by column chromatography.
Reference: [1] Tetrahedron Letters, 2015, vol. 56, # 34, p. 4864 - 4867
  • 9
  • [ 455-24-3 ]
  • [ 1891-90-3 ]
Reference: [1] Organic Letters, 2018, vol. 20, # 19, p. 6046 - 6050
[2] Journal of Organic Chemistry, 2016, vol. 81, # 5, p. 2166 - 2173
[3] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 10, p. 2544 - 2546
[4] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 14, p. 3263 - 3270
  • 10
  • [ 66046-34-2 ]
  • [ 1891-90-3 ]
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[2] RSC Advances, 2016, vol. 6, # 43, p. 37093 - 37098
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  • 11
  • [ 201230-82-2 ]
  • [ 98-56-6 ]
  • [ 1891-90-3 ]
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[2] Chemistry - A European Journal, 2010, vol. 16, # 32, p. 9750 - 9753
[3] Chemistry - An Asian Journal, 2010, vol. 5, # 10, p. 2168 - 2172
  • 12
  • [ 3300-51-4 ]
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  • [ 189245-79-2 ]
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  • 13
  • [ 2338-75-2 ]
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  • 14
  • [ 455-19-6 ]
  • [ 455-18-5 ]
  • [ 1891-90-3 ]
YieldReaction ConditionsOperation in experiment
79 %Chromat. With hydroxylamine hydrochloride; zinc trifluoromethanesulfonate In toluene at 100℃; for 24 h; General procedure for the synthesis of nitriles: A pressure tube was charged with an appropriate amount of Zn(OTf)2 (0.036 mmol, 5.0 mol percent), the corresponding aldehyde (0.72 mmol) and hydroxylamine hydrochloride (1.2 equiv, 0.86 mmol). After the addition of toluene (2.0 mL) the reaction mixture was stirred in a preheated oil bath at 100 °C for 24 h. The mixture was cooled in an ice bath and biphenyl (internal standard) was added. The solution was diluted with dichloromethane and an aliquot was taken for GC-analysis (30 m Rxi-5 ms column, 40-300 °C). The solvent was carefully removed and the residue was purified by column chromatography (n-hexane/ethyl acetate). The analytical properties of the corresponding nitriles are in agreement with the literature.
Reference: [1] Tetrahedron Letters, 2012, vol. 53, # 7, p. 882 - 885
  • 15
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  • 16
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Reference: [1] Organic Letters, 2014, vol. 16, # 2, p. 624 - 627
  • 17
  • [ 3956-07-8 ]
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Reference: [1] Organic Letters, 2015, vol. 17, # 9, p. 2086 - 2089
[2] Organic Process Research and Development, 2016, vol. 20, # 4, p. 836 - 839
  • 18
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  • [ 3599-89-1 ]
  • [ 1891-90-3 ]
YieldReaction ConditionsOperation in experiment
177 mg With caesium carbonate; copper(I) bromide In dimethyl sulfoxide at 120℃; for 16 h; To a solution of propionamidine hydrochloride (1.90 g, 17.5 mmol) and α,α,α-trifluoro-p-tolunitrile (2.0 g, 11.7 mmoles) in 30 mL of dimethylsulfoxide was added cesium carbonate (11.4 g, 34.9 mmol) and copper(I) bromide (0.3 g, 1.05 mmol) and the mixture was stirred and heated at 120 °C for 16 h, open to the air. After the reaction was completed, the reaction mixture was cooled and diluted with water, quenched with saturated aqueous sodium bicarbonate solution and extracted with ethyl acetate. The aqueous layer was separated and extracted twice with ethyl acetate. The combined ethyl acetate layers were washed with saturated EDTA aqueous solution and brine, dried over MgS04 and concentrated to give 1.69 g of crude solid. The crude solid was dissolved in diethyl ether. A white solid was filtered off as by-product, 177 mg of intermediate 4-trifluoromethyl benzamide. The filtrate was concentrated and the residue was purified by a 40 gram silica gel column eluting with a gradient of 10percent, 25percent, 50percent> ethyl acetate in hexanes to give the title compound as a solid (0.57 g). (0454) lH NMR δ 8.20 (d, 2H), 7.69 (d, 2H), 2.90 (q, 2H), 1.42 (t, 3H).
Reference: [1] Patent: WO2016/33285, 2016, A1, . Location in patent: Page/Page column 38
  • 19
  • [ 91888-96-9 ]
  • [ 1891-90-3 ]
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  • 20
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  • 21
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[2] Journal of Organic Chemistry, 2018, vol. 83, # 1, p. 260 - 266
  • 22
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  • 23
  • [ 402-50-6 ]
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[2] Organic and Biomolecular Chemistry, 2017, vol. 15, # 46, p. 9889 - 9894
  • 24
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  • 25
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  • 26
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  • 27
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  • 28
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  • 29
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  • 30
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  • 31
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  • 37
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  • 39
  • [ 1891-90-3 ]
  • [ 1011244-68-0 ]
Reference: [1] Patent: EP2070908, 2009, A1,
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4-Chloro-3-(trifluoromethyl)benzamide

Similarity: 0.80

Chemical Structure| 1288999-05-2

[ 1288999-05-2 ]

2-Amino-5-(trifluoromethyl)benzaldehyde

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Chemical Structure| 1195677-97-4

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4-Iodo-2-(trifluoromethyl)benzamide

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Aryls

Chemical Structure| 360-64-5

[ 360-64-5 ]

2-(Trifluoromethyl)benzamide

Similarity: 0.92

Chemical Structure| 67515-57-5

[ 67515-57-5 ]

4-Fluoro-3-(trifluoromethyl)benzamide

Similarity: 0.87

Chemical Structure| 62584-23-0

[ 62584-23-0 ]

4-Chloro-3-(trifluoromethyl)benzamide

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Chemical Structure| 1288999-05-2

[ 1288999-05-2 ]

2-Amino-5-(trifluoromethyl)benzaldehyde

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Chemical Structure| 1195677-97-4

[ 1195677-97-4 ]

4-Iodo-2-(trifluoromethyl)benzamide

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Amides

Chemical Structure| 360-64-5

[ 360-64-5 ]

2-(Trifluoromethyl)benzamide

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Chemical Structure| 67515-57-5

[ 67515-57-5 ]

4-Fluoro-3-(trifluoromethyl)benzamide

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Chemical Structure| 62584-23-0

[ 62584-23-0 ]

4-Chloro-3-(trifluoromethyl)benzamide

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Chemical Structure| 1195677-97-4

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4-Iodo-2-(trifluoromethyl)benzamide

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Chemical Structure| 824-75-9

[ 824-75-9 ]

4-Fluorobenzamide

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Amines

Chemical Structure| 360-64-5

[ 360-64-5 ]

2-(Trifluoromethyl)benzamide

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Chemical Structure| 67515-57-5

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4-Fluoro-3-(trifluoromethyl)benzamide

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Chemical Structure| 62584-23-0

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4-Chloro-3-(trifluoromethyl)benzamide

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Chemical Structure| 1288999-05-2

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2-Amino-5-(trifluoromethyl)benzaldehyde

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Chemical Structure| 1195677-97-4

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4-Iodo-2-(trifluoromethyl)benzamide

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Trifluoromethyls

Chemical Structure| 360-64-5

[ 360-64-5 ]

2-(Trifluoromethyl)benzamide

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Chemical Structure| 67515-57-5

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4-Fluoro-3-(trifluoromethyl)benzamide

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Chemical Structure| 62584-23-0

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4-Chloro-3-(trifluoromethyl)benzamide

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Chemical Structure| 1288999-05-2

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2-Amino-5-(trifluoromethyl)benzaldehyde

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Chemical Structure| 1195677-97-4

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4-Iodo-2-(trifluoromethyl)benzamide

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