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Chemical Structure| 19217-50-6 Chemical Structure| 19217-50-6

Structure of 19217-50-6

Chemical Structure| 19217-50-6

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Product Details of [ 19217-50-6 ]

CAS No. :19217-50-6
Formula : C8H10O2
M.W : 138.16
SMILES Code : OC1=CC=C(C)C(OC)=C1
MDL No. :MFCD16998731

Safety of [ 19217-50-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501

Application In Synthesis of [ 19217-50-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 19217-50-6 ]

[ 19217-50-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 19217-50-6 ]
  • [ 1597-32-6 ]
  • 6-(3-methoxy-4-methylphenoxy)pyridin-2-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
90% With caesium carbonate; In 1-methyl-pyrrolidin-2-one; at 220℃; for 1h;Microwave irradiation; Sealed tube; To a microwave reaction vessel charged with 3 -methoxy-4-methyl -phenol (200 mg, 1.44 mmol), <strong>[1597-32-6]2-amino-6-fluoropyridine</strong> (200 mg, 1.73 mmol) in NMP (3 mL) was added Cs2C03 (565 mg, 1.73 mmol). The vessel was sealed and the mixture allowed to stir for 1 h at 220C. The mixture was diluted with Et20, washed with H20 and brine, dried over MgS04 and concentrated in vacuo before purification by flash chromatography on silica, eluting with cyclohexane then gradient elution with 0%-50% EtO Ac/Cyclohexane mixtures to give the title compound as a yellow oil (300 mg, 90% yield). 1 H NMR (300MHz, CHCb- d) 7.38 (app. t, / = 7.9 Hz, 1H), 7.09 (d, 7 = 8.3 Hz, 1H), 6.62 (m, 2H), 6.19 (d, / = 7.9 Hz, 1H), 6.02 (d, J = 7.9 Hz, 1H), 3.78 (s, 3H), 2.19 (s, 3H).
 

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