Alternatived Products of [ 194784-10-6 ]
Product Details of [ 194784-10-6 ]
CAS No. : | 194784-10-6 |
MDL No. : | MFCD00033969 |
Formula : |
C10H10N2O4
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
222.20
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 194784-10-6 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 194784-10-6 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 194784-10-6 ]
- Downstream synthetic route of [ 194784-10-6 ]
- 1
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[ 41018-86-4 ]
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[ 194784-10-6 ]
- 2
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[ 194784-10-6 ]
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[ 20864-49-7 ]
Yield | Reaction Conditions | Operation in experiment |
82.30% |
|
Step 3: 1-(2-Amino-3-nitro-phenyl)-ethanone; To a solution <strong>[194784-10-6]N-(2-acetyl-6-nitro-phenyl)-acetamide</strong> (0.3 g, 13.5 mmol) in ethanol (5 ml_), was added an aq. solution of 5 N HCI (4.5 ml.) and the reaction mixture was heated to reflux for one hour. After completion of the reaction, the reaction mixture was cooled to room temperature and evaporated under reduced pressure. The residue was diluted with water (25 ml.) and extracted with ethyl acetate (2X25 ml_). The combined organic layers were washed with a 10% aq. solution of sodium bicarbonate followed by water and dried over anhydrous sodium sulphate, then concentrated to dryness and purified by column chromatography using 15% ethyl acetate in hexane to get the title compound as yellow solid (0.20 g, 82.30%) |
- 3
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[ 5234-26-4 ]
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[ 194784-10-6 ]
Yield | Reaction Conditions | Operation in experiment |
|
With sulfuric acid; nitric acid; at -20 - 0℃; |
Step 2: N-(2-Acetyl-6-nitro-phenyl)-acetamide; A solution of N-(2-acetyl-phenyl)-acetamide (1 g, 5.65 mmol) in cone. H2SO4 (2.8 ml_, 45.2 mmol) was cooled to -200C and fuming nitric acid (2 ml_, 33 mmol) was slowly added. The reaction mixture was warmed to 00C and stirred for 7 h. After completion of the starting material, the reaction mixture was quenched with water and extracted with dichloromethane (2X25 ml_). The combined organic layers were washed with brine and water, then dried over anhydrous sodium sulphate and concontrated to dryness. The resulting residue was purified by column chromatography using 1 %methanol in chloroform to get the title compound as yellow solid |
- 4
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[ 194784-10-6 ]
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[ 68-12-2 ]
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[ 23833-99-0 ]
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4-chloro-8-nitro-quinoline-3-carbaldehyde
[ No CAS ]
- 5
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[ 194784-10-6 ]
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[ 2096-40-4 ]
- 6
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[ 194784-10-6 ]
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[ 159724-49-9 ]