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Product Details of [ 19541-96-9 ]

CAS No. :	19541-96-9	MDL No. :	MFCD02708434
Formula :	C₉H₁₀N₄	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	174.20	Pubchem ID :	-
Synonyms :

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Application In Synthesis of [ 19541-96-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 19541-96-9 ]

[ 19541-96-9 ] Synthesis Path-Downstream 1~12

1
[ 598-54-9 ]
[ 110877-64-0 ]
[ 19541-96-9 ]
[ 364727-90-2 ]

Yield	Reaction Conditions	Operation in experiment
81%	With potassium carbonate; acetic acid; In N,N-dimethyl-formamide;	Reference Example 2-43 4,5-Difluoro-2-[[3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid Under an argon atmosphere, a solution of 3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-ylamine (6.01 g, 34.5 mmol), 2-chloro-4,5-difluorobenzoic acid (6.64 g, 34.5 mmol), copper acetate (II) (0.718 g, 3.95 mmol) and potassium carbonate (4.77 g, 34.5 mmol) in N,N-dimethylformamide (30 mL) was heated under reflux for 2 hours. The solution was cooled to room temperature, and poured into water. The solution was made weakly acidic by the addition of acetic acid, and the resulting crude crystals were collected by filtration. The crystals were washed with water and air dried to give the title compound (9.21 g, 81% yield). mp: 247-248 C. (recrystallized from methanol). NMR (DMSO-d6) delta: 2.25 (3H, s), 6.33 (1H, s), 7.28-7.34 (1H, m), 7.46-7.56 (1H, m), 7.80-8.02 (3H, m), 8.30-8.44 (1H, m), 12.30 (1H, br s), hidden (1H).
81%	With potassium carbonate; acetic acid; In N,N-dimethyl-formamide;	Production Example 7 4,5-Difluoro-2-[[3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid Under an argon atmosphere, a solution of 3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-ylamine (6.01 g, 34.5 mmol), 2-chloro-4,5-difluorobenzoic acid (6.64 g, 34.5 mmol), copper acetate (II) (0.718 g, 3.95 mmol) and potassium carbonate (4.77 g, 34.5 mmol) in N,N-dimethylformamide (30 mL) was heated under reflux for 2 hrs. The solution was cooled to room temperature, and poured into water. The solution was made weakly acidic by the addition of an acetic acid solution, and the resulting crude crystals were collected by filtration. The crystals were washed with water and air dried to give the title compound (9.21 g, 81% yield). mp: 247-248C (recrystallized from methanol). NMR (DMSO-d6) delta: 2.25 (3H, s), 6.33 (1H, s), 7.28-7.34 (1H, m), 7.46-7.56 (1H, m), 7.80-8.02 (3H, m), 8.30-8.44 (1H, m), 12.30 (1H, br s), hidden (1H).

Reference： [1]Patent: US2003/187014,2003,A1
[2]Patent: EP1380296,2004,A1

2
[ 111771-08-5 ]
[ 19541-96-9 ]
[ 364725-93-9 ]

Yield	Reaction Conditions	Operation in experiment
51%		EXAMPLE 2-78 4-Chloro-5-fluoro-3-methyl-1-(2-pyridinyl)-1H-pyrazolo[3,4-b]quinoline Following the procedures described in Reference Example 2-5 and Example 2-1, the title compound was prepared from <strong>[111771-08-5]2-fluoro-6-iodobenzoic acid</strong> and 3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-ylamine (51% yield). mp: 160-161 C. (recrystallized from ethyl acetate). NMR (CDCl3) delta: 3.01 (3H, s), 7.14-7.29 (2H, m), 7.63-7.76 (1H, m), 7.88-8.01 (2H, m), 8.65-8.78 (2H, m).

Reference： [1]Patent: US2003/187014,2003,A1

3
[ 657-06-7 ]
[ 598-54-9 ]
[ 19541-96-9 ]
[ 364727-78-6 ]

Yield	Reaction Conditions	Operation in experiment
89%	With potassium carbonate; acetic acid; In N,N-dimethyl-formamide;	Reference Example 2-10 2-[[3-Methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]-5-(trifluoromethyl)benzoic acid A solution of 3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-ylamine (8.71 g, 50.0 mmol), <strong>[657-06-7]2-chloro-5-(trifluoromethyl)benzoic acid</strong> (12.4 g, 55.0 mmol), copper acetate (II) (1.00 g, 5.50 mmol) and potassium carbonate (7.60 g, 55.0 mmol) in N,N-dimethylformamide (50 mL) was heated under reflux for 1.5 hours under an argon atmosphere. The solution was cooled to room temperature, and poured into water. The solution was made acidic by the addition of acetic acid, and the resulting crude crystals were collected by filtration. The crystals were washed with water and air dried to give the title compound (17.7 g, 89% yield). mp: 228-229 C. (recrystallized from ethyl acetate). NMR (CDCl3) delta: 2.37 (3H, s), 6.19 (1H, s), 7.13 (1H, ddd, J=1.0 Hz, 4.8 Hz, 7.4 Hz), 7.70-7.85 (3H, m), 7.93 (1H, d, J=8.4 Hz), 8.39 (1H, d, J=1.8 Hz), 8.45 (1H, ddd, J=0.8 Hz, 1.8 Hz, 4.8 Hz), 12.46 (1H, br s), hidden (1H).
89%	With potassium carbonate; acetic acid; In N,N-dimethyl-formamide;	Production Example 4 2-[[3-Methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]-5-(trifluoromethyl)benzoic acid A solution of 3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-ylamine (8.71 g, 50.0 mmol), <strong>[657-06-7]2-chloro-5-(trifluoromethyl)benzoic acid</strong> (12.4 g, 55.0 mmol), copper acetate (II) (1.00 g, 5.50 mmol) and potassium carbonate (7.60 g, 55.0 mmol) in N,N-dimethylformamide (50 mL) was heated at reflux for 1.5 hrs. under an argon atmosphere. The solution was cooled to room temperature, and poured into water. The solution was made acidic by the addition of an acetic acid solution, and the resulting crude crystals were collected by filtration. The crystals were washed with water and air dried to give the title compound (17.7 g, 89% yield). mp: 228-229C (recrystallized from ethyl acetate). NMR (CDCl3) delta: 2.37 (3H, s), 6.19 (1H, s), 7.13 (1H, ddd, J=1.0Hz, 4.8Hz, 7.4Hz), 7.70-7.85 (3H, m), 7.93 (1H, d, J=8.4Hz), 8.39 (1H, d, J=1.8Hz), 8.45 (1H, ddd, J=0.8Hz, 1.8Hz, 4.8Hz), 12.46 (1H, br s), hidden (1H).

Reference： [1]Patent: US2003/187014,2003,A1
[2]Patent: EP1380296,2004,A1

4
[ 50-82-8 ]
[ 19541-96-9 ]
[ 364727-84-4 ]

Yield	Reaction Conditions	Operation in experiment
92%		Reference Example 2-26 4,5-Dichloro-2-[[3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid Following the procedure described in Reference Example 2-5, the title compound was prepared from <strong>[50-82-8]2,4,5-trichlorobenzoic acid</strong> and 3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-ylamine (92% yield). mp: 288-289 C. (recrystallized from ethanol). NMR (DMSO-d6) delta: 2.26 (3H, s), 6.32 (1H, s), 7.29-7.35 (1H, m), 7.69 (1H, s), 7.83 (1H, d, J=8.4 Hz), 7,94-8.03 (2H, m), 8.41-8.44 (1H, m), 12.34 (1H, br s), hidden (1H).

Reference： [1]Patent: US2003/187014,2003,A1

5
[ 88-67-5 ]
[ 598-54-9 ]
[ 19541-96-9 ]
2-[[3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
98%	With potassium carbonate; acetic acid; In N,N-dimethyl-formamide;	Reference Example 2-5 2-[[3-Methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid A solution of 3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-ylamine (5.23 g, 30 mmol), o-iodobenzoic acid (8.93 g, 36 mmol), copper acetate (II) (0.654 g, 3.6 mmol) and potassium carbonate (4.98 g, 36 mmol) in N,N-dimethylformamide (30 mL) was heated under reflux for 1 hour under an argon atmosphere. After the solution was cooled to room temperature, the mixture was poured into water. The solution was made weakly acidic by the addition of acetic acid, and the resulting crude crystals were collected by filtration. The crystals were washed with water and air dried to give the title compound (8.64 g, 98% yield).

Reference： [1]Patent: US2003/187014,2003,A1

6
[ 364727-87-7 ]
[ 598-54-9 ]
[ 19541-96-9 ]
[ 364727-88-8 ]

Yield	Reaction Conditions	Operation in experiment
8%	With potassium carbonate; acetic acid; In N,N-dimethyl-formamide;	Reference Example 2-41 Methyl 2,3-difluoro-6-[[3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoate A solution of 3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-ylamine (6.16 g, 35.4 mmol), methyl 6-bromo-2,3-difluorobenzoate (8.11 g, 32.3 mmol), copper acetate (II) (0.49 g, 2.7 mmol) and potassium carbonate (4.46 g, 323 mmol) in N,N-dimethylformamide (30 mL) was heated under reflux for 1 hour under an argon atmosphere, and the solution was allowed to cool to room temperature and poured into water. The solution was made weakly acidic by the addition of acetic acid, and organic matter was extracted with ethyl acetate. The extract was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue thus obtained was purified by silica gel column chromatography (hexane:ethyl acetate=10:1 to 5:1) to give the title compound (0.86 g, 8% yield). NMR (CDCl3) delta: 2.30 (3H, s), 4.00 (3H, s), 5.94 (1H, s), 7.11-7.27 (2H, m), 7.23 (1H, dd, J=8.2 Hz, 9.2 Hz), 7.80 (1H, ddd, J=1.8 Hz, 7.4 Hz, 8.4 Hz), 7.94 (1H, ddd, J=1.0 Hz, 1.2 Hz, 8.4 Hz), 8.50 (1H, ddd, J=1.0 Hz, 1.8 Hz, 5.0 Hz), 11.60 (1H, br s).

Reference： [1]Patent: US2003/187014,2003,A1

7
[ 52548-63-7 ]
[ 19541-96-9 ]
[ 364725-95-1 ]

Yield	Reaction Conditions	Operation in experiment
57%		EXAMPLE 1-52 4-Chloro-6-fluoro-3-methyl-1-(2-pyridinyl)-1H-pyrazolo[3,4-b]quinoline Following the procedures described in Reference Example 1-11 and Example 1-34, the title compound was prepared from <strong>[52548-63-7]5-fluoro-2-iodobenzoic acid</strong> and 3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-ylamine (57% yield). mp: 185-187 C. (recrystallized from ethyl acetate). NMR (DMSO-d6) delta: 3.00 (3H, s), 7.21-7.28 (1H, m), 7.62 (1H, ddd, J=3.0 Hz, 5.4 Hz, 9.4 Hz), 7.89-7.99 (2H, m), 8.19 (1H, dd, J=5.4 Hz, 9.4 Hz), 8.69 (1H, d, J=3.6 Hz), 8.77 (1H, d, J=8.2 Hz).
57%		EXAMPLE 2-80 4-Chloro-6-fluoro-3-methyl-1-(2-pyridinyl)-1H-pyrazolo[3,4-b]quinoline Following the procedures described in Reference Example 2-5 and Example 2-1, the title compound was prepared from <strong>[52548-63-7]5-fluoro-2-iodobenzoic acid</strong> and 3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-ylamine (57% yield). mp: 185-187 C. (recrystallized from ethyl acetate). NMR (DMSO-d6) delta: 3.00 (3H, s), 7.21-7.28 (1H, m), 7.62 (1H, ddd, J=3.0 Hz, 5.4 Hz, 9.4 Hz), 7.89-7.99 (2H, m), 8.19 (1H, dd, J=5.4 Hz, 9.4 Hz), 8.69 (1H, d, J=3.6 Hz), 8.77 (1H, d, J=8.2 Hz).

Reference： [1]Patent: US2003/187014,2003,A1
[2]Patent: US2003/187014,2003,A1

8
[ 22433-91-6 ]
[ 19541-96-9 ]
[ 364780-76-7 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
1: 99% 2: 14%	In tetrahydrofuran; methanol; sodium hydroxide; trichlorophosphate	2.63 Methyl 4-chloro-3-methyl-1-(2-pyridinyl)-1H-pyrazolo[3,4-b]quinoline-6-carboxylate EXAMPLE 2-63 Methyl 4-chloro-3-methyl-1-(2-pyridinyl)-1H-pyrazolo[3,4-b]quinoline-6-carboxylate Following the procedure described in Reference Example 2-5, 4-[[3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]isophthalic acid was prepared from bromoisophthalic acid and 3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-ylamine (99% yield). A solution of the compound (23.0 g, 68.0 mmol) in phosphorus oxychloride (108 g, 704 mmol) was heated under reflux for I hour. The reaction solution was allowed to cool to room temperature, and the solvent was evaporated under reduced pressure. To a stirred mixture of the residue in tetrahydrofuran (100 mL), methanol (10 mL) was added dropwise carefully, and the precipitate was collected by filtration. The precipitate was dissolved in a sodium hydroxide solution, and organic matter was extracted with chloroform. The extract was washed with saturated brine and water, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue thus obtained was purified by silica gel column chromatography (chloroform) to give the title compound (3.40 g, 14% yield). mp: 199-200° C. (recrystallized from ethyl acetate). NMR (CDCl3) δ: 3.01 (3H, s), 4.04 (3H, s), 7.27 (1H, ddd, J=1.0 Hz, 4.8 Hz, 7.4 Hz), 7.95 (1H, ddd, J=1.8 Hz, 7.4 Hz, 8.4 Hz), 8.19 (1H, d, J=9.0 Hz), 8.38 (1H, dd, J=1.8 Hz, 9.0 Hz), 8.69 (1H, ddd, J=0.8 Hz, 1.8 Hz, 4.8 Hz), 8.78 (1H, ddd, J=0.8 Hz, 1.0 Hz, 8.4 Hz), 9.15 (1H, d, J=1.8 Hz).

Reference： [1]Current Patent Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED - US2003/187014, 2003, A1

9
[ 13420-63-8 ]
[ 19541-96-9 ]
[ 364727-83-3 ]

Yield	Reaction Conditions	Operation in experiment
28%		Reference Example 2-22 6-Chloro-2-[[3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid Following the procedure described in Reference Example 2-5, the title compound was prepared from <strong>[13420-63-8]2-chloro-6-iodobenzoic acid</strong> and 3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-ylamine (28% yield). mp: 201-202 C. (recrystallized from ethanol). NMR (DMSO-d6) delta: 2.22 (3H, s), 6.12 (1H, s), 7.10 (1H, dd, J=1.0 Hz, 7.8 Hz), 7.32 (1H, ddd, J=1.0 Hz, 5.0 Hz, 7.0 Hz), 7.41 (1H, dd, J=7.4 Hz, 7.8 Hz), 7.52 (1H, dd, J=1.0 Hz, 8.4 Hz), 7.88 (1H, dd, J=1.0 Hz, 7.4 Hz), 8.01 (1H, ddd, J=1.8 Hz, 7.0 Hz, 8.4 Hz), 8.42 (1H, ddd, J=0.8 Hz, 1.8 Hz, 5.0 Hz), 11.35 (1H, br s), hidden (1H).

Reference： [1]Patent: US2003/187014,2003,A1

10
[ 387-48-4 ]
[ 19541-96-9 ]
[ 364725-99-5 ]

Yield	Reaction Conditions	Operation in experiment
36%		EXAMPLE 2-84 4-Chloro-8-fluoro-3-methyl-1-(2-pyridinyl)-1H-pyrazolo[3,4-b]quinoline Following the procedures described in Reference Example 2-5 and Example 2-1, the title compound was prepared from <strong>[387-48-4]3-fluoro-2-iodobenzoic acid</strong> and 3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-ylamine (36% yield). mp: 191 C. (recrystallized from ethyl acetate). NMR (CDCl3) delta: 3.01 (3H, s), 7.26 (1H, ddd, J=1.2 Hz, 4.8 Hz, 7.4 Hz), 7.45-7.59 (2H, m), 7.97 (1H, ddd, J=1.2 Hz, 7.4 Hz, 8.4 Hz), 8.15-8.23 (1H, m), 8.68 (1H, ddd, J=0.8 Hz, 1.8 Hz, 4.8 Hz), 8.92 (1H, ddd, J=0.8 Hz, 1.2 Hz, 8.4 Hz).

Reference： [1]Patent: US2003/187014,2003,A1

11
[ 56096-89-0 ]
[ 19541-96-9 ]
[ 364727-86-6 ]

Yield	Reaction Conditions	Operation in experiment
86%		Reference Example 2-34 4-Fluoro-2-[[3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid Following the procedure described in Reference Example 2-5, the title compound was prepared from <strong>[56096-89-0]4-fluoro-2-iodobenzoic acid</strong> and 3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-ylamine (86% yield). mp: 242-243 C. (recrystallized from ethanol). NMR (DMSO-d6) delta: 2.26 (3H, s), 6.35 (1H, s), 6.74 (1H, ddd, J=2.2 Hz, 8.0 Hz, 8.8 Hz), 7.27-7.36 (2H, m), 7.83 (1H, ddd, J=0.6 Hz, 1.2 Hz, 8.4 Hz), 7.95-8.06 (2H, m), 8.44 (1H, ddd, J=0.6 Hz, 1.8 Hz, 4.8 Hz), 12.37 (1H, br s), hidden (1H).

Reference： [1]Patent: US2003/187014,2003,A1

12
[ 86522-89-6 ]
[ 19541-96-9 ]
[ 364727-91-3 ]

Yield	Reaction Conditions	Operation in experiment
24%		R.2.45 4-Chloro-5-fluoro-2-[[3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid Reference Example 2-45 4-Chloro-5-fluoro-2-[[3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid Following the procedure described in Reference Example 2-5, the title compound was prepared from 2,4-dichloro-5-fluorobenzoic acid and 3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-ylamine (24% yield). mp: 245-246° C. (recrystallized from ethyl acetate). NMR (DMSO-d6) δ: 2.25 (3H, s), 6.28 (1H, s), 7.28-7.35 (1H, m), 7.64 (1H, d, J=6.6 Hz), 7.80-7.85 (2H, m), 7.95-8.03 (1H, m), 8.42 (1H, dd, J=1.2 Hz, 4.8 Hz), 12.21 (1H, br s), hidden (1H).

Reference： [1]Current Patent Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED - US2003/187014, 2003, A1

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P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 19541-96-9 ] {[proInfo.proName]}

Quality Control of [ 19541-96-9 ]

Related Doc. of [ 19541-96-9 ]

Product Details of [ 19541-96-9 ]

Safety of [ 19541-96-9 ]

Application In Synthesis of [ 19541-96-9 ]

[ 19541-96-9 ] Synthesis Path-Downstream 1~12

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry