Home Cart 0 Sign in  

[ CAS No. 197638-76-9 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 197638-76-9
Chemical Structure| 197638-76-9
Structure of 197638-76-9 * Storage: {[proInfo.prStorage]}

Quality Control of [ 197638-76-9 ]

Related Doc. of [ 197638-76-9 ]

SDS
Alternatived Products of [ 197638-76-9 ]
Alternatived Products of [ 197638-76-9 ]

Product Details of [ 197638-76-9 ]

CAS No. :197638-76-9 MDL No. :MFCD05864670
Formula : C13H18N2O Boiling Point : 364.6°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :218.29 g/mol Pubchem ID :-
Synonyms :

Safety of [ 197638-76-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 197638-76-9 ]

  • Downstream synthetic route of [ 197638-76-9 ]

[ 197638-76-9 ] Synthesis Path-Downstream   1~14

  • 1
  • [ 111-74-0 ]
  • [ 197638-76-9 ]
  • [ 179328-89-3 ]
YieldReaction ConditionsOperation in experiment
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane for 8h; Ambient temperature;
  • 2
  • [ 74-89-5 ]
  • [ 197638-76-9 ]
  • [ 197638-79-2 ]
YieldReaction ConditionsOperation in experiment
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane for 2h; Ambient temperature;
  • 3
  • [ 186650-78-2 ]
  • [ 197638-76-9 ]
YieldReaction ConditionsOperation in experiment
With diisobutylaluminium hydride In hexane; toluene at 50℃; for 1.5h;
With diisobutylaluminium hydride In methanol; dichloromethane; water; toluene 13.C Step C Step C [4-(4-ethylpiperazinyl)benzaldehyde Under a nitrogen atmosphere, a stirred solution of 2.8 grams (0.013 mole) of 4-(4-ethyl)piperazinylbenzonitrile in 35 mL of anhydrous toluene (available from Aldrich Chemical Company) was cooled to -70° C. and 12 mL (0.02 mole) of diisobutylaluminum hydride (1.5M in toluene, available from Aldritch Chemical Company) was added dropwise at a rate to maintain the temperature below -60° C. during about a 15 minute period. Upon completion of addition, the reaction mixture was stirred at -60° C. for two hours. At the conclusion of this period, 10 mL of methanol was added dropwise followed by 10 mL of water. The resulting solution was allowed to warm to ambient temperature. Once at the prescribed temperature, 10 mL of methylene chloride was added. The resulting mixture was filtered and the filtrate was transferred to a separatory funnel. The organic layer was separated from the aqueous layer, dried with sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure, yielding 1.6 grams of an orange paste. The orange pasted was was filtered through a silica gel plug. The filter cake was washed with one 75 mL portion of methylene chloride followed by one 50 mL portion of a 5% methanol/95% methylene chloride solution. The filtrate was concentrated under reduced pressure, yielding 0.5 gram of title compound. The NMR spectrum was consistent with the proposed structure.
0.5 g Stage #1: 4-(4-ethyl-piperazin-1-yl)-benzonitrile With diisobutylaluminium hydride In toluene at -70 - -60℃; for 2.25h; Inert atmosphere; Stage #2: With water In methanol; toluene Inert atmosphere; 13.C Step C 4-(4-ethylpiperazinyl)benzaldehyde Under a nitrogen atmosphere, a stirred solution of 2.8 grams (0.013 mole) of 4-(4- ethyl)piperazinylbenzonitrile in 35 mL of anhydrous toluene (available from Aldrich Chemical Company) was cooled to -70°C and 12 mL (0.02 mole) of diisobutylaluminum hydride (1.5M in toluene, available from Aldritch Chemical Company) was added dropwise at a rate to maintain the temperature below -60°C during about a 15 minute period. Upon completion of addition, the reaction mixture was stirred at -60°C for two hours. At the conclusion of this period, 10 mL of methanol was added dropwise followed by 10 mL of water. The resulting solution was allowed to warm to ambient temperature. Once at the prescribed temperature, 10 mL of methylene chloride was added. The resulting mixture was filtered and the filtrate was transferred to a separatory funnel. The organic layer was separated from the aqueous layer, dried with sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure, yielding 1.6 grams of an orange paste. The orange pasted was was filtered through a silica gel plug. The filter cake was washed with one 75 mL portion of methylene chloride followed by one 50 mL portion of a 5% methanol/95% methylene chloride solution. The filtrate was concentrated under reduced pressure, yielding 0.5 gram of title compound. The NMR spectrum was consistent with the proposed structure.
  • 4
  • [ 109-97-7 ]
  • [ 100-52-7 ]
  • [ 197638-76-9 ]
  • 5-[4-(N-ethylpiperazinyl)phenyl]-10,15,20-triphenylporphine [ No CAS ]
YieldReaction ConditionsOperation in experiment
2% With propionic acid for 0.5h; Heating;
  • 5
  • [ 109-97-7 ]
  • [ 197638-76-9 ]
  • 5,10,15,20-tetra-[4-(N-ethylpiperazinyl)phenyl]porphine [ No CAS ]
YieldReaction ConditionsOperation in experiment
4.5% With propionic acid for 0.5h; Heating;
  • 6
  • [ 197638-76-9 ]
  • [ 197638-81-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: NaB(OAc)3H, AcOH / CH2Cl2 / 2 h / Ambient temperature 2: NaB(OAc)3H, AcOH / CH2Cl2 / 1 h / Ambient temperature
  • 7
  • [ 197638-76-9 ]
  • [ 197638-69-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: NaB(OAc)3H, AcOH / CH2Cl2 / 2 h / Ambient temperature 2: NaB(OAc)3H, AcOH / CH2Cl2 / 1 h / Ambient temperature 3: ethanol; H2O / 2 h / 70 °C
  • 8
  • [ 197638-76-9 ]
  • N-Ethyl-N-(2-[4-(4-ethyl-piperazin-1-yl)-benzyl]-methyl-amino}-ethyl)-4-oxo-4-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-11-yl)-butyramide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: NaB(OAc)3H, AcOH / CH2Cl2 / 2 h / Ambient temperature 2: NaB(OAc)3H, AcOH / CH2Cl2 / 1 h / Ambient temperature 3: ethanol; H2O / 2 h / 70 °C 4: 56 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, HOBT / dimethylformamide / 8 h / Ambient temperature
  • 9
  • [ 197638-76-9 ]
  • N-Ethyl-N-(2-{ethyl-[4-(4-ethyl-piperazin-1-yl)-benzyl]-amino}-ethyl)-4-oxo-4-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-11-yl)-butyramide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: NaB(OAc)3H, AcOH / CH2Cl2 / 8 h / Ambient temperature 2: 67 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, HOBT / dimethylformamide / 8 h / Ambient temperature
  • 11
  • [ 5308-25-8 ]
  • [ 34421-94-8 ]
  • [ 197638-76-9 ]
YieldReaction ConditionsOperation in experiment
26% Stage #1: 4-ethylpiperazine; 4-bromobenzaldehyde diethyl acetal With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 100℃; for 5h; Inert atmosphere; Stage #2: With hydrogenchloride In water; toluene for 2.5h;
  • 13
  • [ 360-97-4 ]
  • [ 197638-76-9 ]
  • [ 1415583-49-1 ]
YieldReaction ConditionsOperation in experiment
With sodium hydrogensulfite; In ISOPROPYLAMIDE; at 150℃; for 1.5h; A mixture of <strong>[360-97-4]5-aminoimidazole-4-carboxamide</strong> (6.3 gm, 0.05 moles), N-ethyl-N'-(4- formylphenyl)piperazine (10.9 gm, 0,05 moles), sodium metabisulfite (7.13 gm, 0.037 moles) and water (675mu) in dimethylacetamide (75 mL) was heated at 150C with stirring for 90 minutes. The heat was removed and water (150 mL) was cautiously added. The resulting brown solution was then cooled in an ice bath with stirring. The solid which separated was isolated by filtration, washed with water and dried. TLC (silica, 25% methanol in methylene chloride) showed the presence of two products; a bright yellow compound with rf = 0.48 and a colorless, blue fluorescent compound with rf = 0.25. The total yield was 2.4 gm.[0245] The crude product was dissolved in 20% methanol in chloroform (200 mL) and silica gel (25 gm) was added. This mixture was stripped of solvent under vacuum to give the product mixture adsorbed to silica. This material was deposited on top of a silica column (18in X 2 in). The column was then developed using 20% methanol in chloroform using 5 psi nitrogen to accelerate the process. The two compounds were cleanly separated with the yellow compound eluting first. The fractions containing the separated compounds were evaporated to give the yellow compound in a yield of 0.77 gm and the colorless compound in a yield of 0.90 gm. The NMR of the latter compound was consistent with the quinazolinone structure.
  • 14
  • [ 109-77-3 ]
  • [ 197638-76-9 ]
  • 2-[4-(4-methylpiperazin-1-yl)benzylidene]malononitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% With piperidine In ethanol at 20℃; for 1.5h;
Historical Records

Related Functional Groups of
[ 197638-76-9 ]

Aryls

Chemical Structure| 27913-98-0

[ 27913-98-0 ]

4-(Piperazin-1-yl)benzaldehyde

Similarity: 1.00

Chemical Structure| 27913-99-1

[ 27913-99-1 ]

4-(4-Methylpiperazin-1-yl)benzaldehyde

Similarity: 1.00

Chemical Structure| 10159-39-4

[ 10159-39-4 ]

4,4'-(Piperazine-1,4-diyl)dibenzaldehyde

Similarity: 1.00

Chemical Structure| 870703-56-3

[ 870703-56-3 ]

3-(Piperazin-1-yl)benzaldehyde

Similarity: 0.97

Chemical Structure| 1424939-17-2

[ 1424939-17-2 ]

4-(4-Methylpiperazin-1-yl)benzaldehyde hydrochloride

Similarity: 0.97

Aldehydes

Chemical Structure| 27913-98-0

[ 27913-98-0 ]

4-(Piperazin-1-yl)benzaldehyde

Similarity: 1.00

Chemical Structure| 27913-99-1

[ 27913-99-1 ]

4-(4-Methylpiperazin-1-yl)benzaldehyde

Similarity: 1.00

Chemical Structure| 10159-39-4

[ 10159-39-4 ]

4,4'-(Piperazine-1,4-diyl)dibenzaldehyde

Similarity: 1.00

Chemical Structure| 870703-56-3

[ 870703-56-3 ]

3-(Piperazin-1-yl)benzaldehyde

Similarity: 0.97

Chemical Structure| 1424939-17-2

[ 1424939-17-2 ]

4-(4-Methylpiperazin-1-yl)benzaldehyde hydrochloride

Similarity: 0.97

Related Parent Nucleus of
[ 197638-76-9 ]

Piperazines

Chemical Structure| 27913-98-0

[ 27913-98-0 ]

4-(Piperazin-1-yl)benzaldehyde

Similarity: 1.00

Chemical Structure| 27913-99-1

[ 27913-99-1 ]

4-(4-Methylpiperazin-1-yl)benzaldehyde

Similarity: 1.00

Chemical Structure| 10159-39-4

[ 10159-39-4 ]

4,4'-(Piperazine-1,4-diyl)dibenzaldehyde

Similarity: 1.00

Chemical Structure| 870703-56-3

[ 870703-56-3 ]

3-(Piperazin-1-yl)benzaldehyde

Similarity: 0.97

Chemical Structure| 1424939-17-2

[ 1424939-17-2 ]

4-(4-Methylpiperazin-1-yl)benzaldehyde hydrochloride

Similarity: 0.97