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Chemical Structure| 198967-23-6 Chemical Structure| 198967-23-6

Structure of 198967-23-6

Chemical Structure| 198967-23-6

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Product Details of [ 198967-23-6 ]

CAS No. :198967-23-6
Formula : C9H9ClFNO2
M.W : 217.63
SMILES Code : O=C(N(OC)C)C1=CC=C(Cl)C=C1F
MDL No. :MFCD03428601

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 198967-23-6 ]

[ 198967-23-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 198967-23-6 ]
  • [ 75-16-1 ]
  • [ 175711-83-8 ]
YieldReaction ConditionsOperation in experiment
In diethyl ether; dichloromethane; at 0 - 20℃; for 2h; Reference Example 8 : 1- (4-chloro-2-fluorophenyl) ethanone To a solution 4-chloro-2-fluorobenzoic acid (leq) in CH2C12 (1.6 M) was added N, O-dimethylhydroxylamine hydrochloride (1. 5 eq), EDCI (1.5 eq) and triethylamine (4 eq). The reaction mixture was stirred at rt for 16 hrs, concentrated and 0. 5M aqueous citric acid was added. The mixture was extracted with 1: 1 EtOAc: Et20. The combined organic layers were washed with brine, dried over MgS04 and concentrated to give 4-chloro-2-fluoro-N-methoxy-N- methylbenzamide, which was used as such for the next step. To a solution of the above benzamide (leq) in CHsClz (0.5 M) at 0C was added 3M/EtzO MeMgBr (1.25 eq). The reaction mixture was slowly warmed to rt over a 2 hrs period, quenched with 0.5 M aqueous citric acid and extracted with Et20. The combined organic layers were washed with brine, dried over MgS04 and concentrated. The residue was purified by flash chromatography on silica gel eluted with 20% EtOAc/hexane to give the title compound.
 

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