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Quality Control of 2-Bromo-4-fluoroanisole Purity: 98% SDS Specification

COA

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NMR

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CNMR

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HPLC

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Product Details of 2-Bromo-4-fluoroanisole

CAS No. :	452-08-4
Formula :	C₇H₆BrFO
M.W :	205.02
SMILES Code :	COC1=CC=C(F)C=C1Br
MDL No. :	MFCD00012014
InChI Key :	JIQXVIJARQLCOY-UHFFFAOYSA-N
Pubchem ID :	136292

Safety of 2-Bromo-4-fluoroanisole

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of 2-Bromo-4-fluoroanisole

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 452-08-4 ]

[ 452-08-4 ] Synthesis Path-Downstream 1~11

1
[ 2591-86-8 ]
[ 452-08-4 ]
[ 19415-51-1 ]

References: [1]Journal of Organic Chemistry,1993,vol. 58,p. 1385 - 1392.
[2]Journal of Organic Chemistry,2013,vol. 78,p. 5955 - 5963.

2
[ 452-08-4 ]
[ 72955-97-6 ]

Yield	Reaction Conditions	Operation in experiment
		106 ml of 2.5 M butyllithium in hexane are added dropwise at -20 C. to a solution of 2-bromo-4-fluoro-1-methoxy-benzene (50 g) in 1 l of pentane, and stirred for 15 min at -10 C., then cooled to -30 C. Then trimethylborate (30 ml) is added, stirred 30 min at 0 C., cooled to -10 C., followed by the addition of a 32% peracetic solution (103 ml) over 45 min keeping the temperature to below -5 C. and stirring 30 min at 0 C. The mixture is cooled to -10 C., 150 ml of a saturated NaHSO3 solution are added, stirred 1 h at AT, then after adding water, neutralizing with 330 g of NaHCO3 and decanting the pentane, the aqueous layer is extracted with DCM. The organic layer is washed with sodium hydroxide, the aqueous layer is acidified with a concentrated HCl solution, extracted with DCM and the organic layer is dried over MgSO4, filtered and concentrated to dryness. 27.1 g of desired product are obtained.

References: [1]Bulletin des Societes Chimiques Belges,1993,vol. 102,p. 217 - 226.
[2]Patent: US2009/233910,2009,A1 .Location in patent: Page/Page column 117-118.
[3]European Journal of Medicinal Chemistry,2015,vol. 89,p. 524 - 539.

3
[ 452-08-4 ]
[ 1068-55-9 ]
[ 68-12-2 ]
[ 19415-51-1 ]
[ 1441770-58-6 ]