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[ CAS No. 2591-86-8 ] {[proInfo.proName]}

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Chemical Structure| 2591-86-8
Chemical Structure| 2591-86-8
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Product Details of [ 2591-86-8 ]

CAS No. :2591-86-8 MDL No. :MFCD00006483
Formula : C6H11NO Boiling Point : -
Linear Structure Formula :HCON(CH2CH2)2CH2 InChI Key :FEWLNYSYJNLUOO-UHFFFAOYSA-N
M.W : 113.16 Pubchem ID :17429
Synonyms :

Safety of [ 2591-86-8 ]

Signal Word:Danger Class:6.1
Precautionary Statements:P280-P305+P351+P338-P312 UN#:2810
Hazard Statements:H302-H311-H319 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 2591-86-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2591-86-8 ]

[ 2591-86-8 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 2591-86-8 ]
  • [ 27139-97-5 ]
  • [ 58966-34-0 ]
YieldReaction ConditionsOperation in experiment
With n-butyllithium; In tetrahydrofuran; Step 1 5-chloro-2-methylbenzaldehyde To a solution of <strong>[27139-97-5]2-bromo-4-chlorotoluene</strong> (20.0 g; 97.3 mmol) in 300 mL of THF at -78° C. was added dropwise a 2.5 M solution of n-BuLi (102.2 mmol). After 30 min of stirring at that temperature, 1-formylpiperidine (11.4 mL) in 10 mL of THF was added and the solution left for 1 h. It was brought to 0° C., quenched with NH4OAc (25percent) and diluted with EtOAc. The organic phase was dried over Na2SO4, filtered and the solvent removed to yield 13.3 g of the title compound. 1H NMR (CDCl3) delta2.6 (3H, s), 7.15 (1H, d), 7.4 (1H, d), 7.75 (1H, s) and 10.2 (1H, s).
13.3 g (89%) With n-butyllithium; In tetrahydrofuran; Step 1 Ethyl (E)-3-(5-chloro-2-methylphenyl)-2-propenoate To 2-bromo-4-chloro toluene (20.0 g; 97.3 mmol) in 300 mL of THF at -78° C. was added n-BuLi 2.5M (40.8 mL) dropwise. After 20 min. 1-formylpiperidine (11.4 mL; 103.0 mmol) in 10 mL of THF was added dropwise. After 30 min the reaction mixture was brought to 0° C. and quenched with HCl (10percent) and diluted with EtOAc. The organic phase was collected, dry and the solvent evaporated to yield 13.3 g (89percent) of 5-chloro-2-methylbenzaldehyde.
  • 2
  • [ 2591-86-8 ]
  • [ 54396-44-0 ]
  • [ 868-85-9 ]
  • dimethyl (((2-methyl-3-(trifluoromethyl)phenyl)amino)(piperidin-1-yl)methyl)phosphonate [ No CAS ]
YieldReaction ConditionsOperation in experiment
90% With chitosan; In neat (no solvent); at 75℃; for 0.05h;Microwave irradiation; Green chemistry; General procedure: An equimolar mixture of <strong>[54396-44-0]2-methyl-3-(trifluoromethyl)aniline</strong> (0.351 g, 0.002 mol), corresponding aldehyde (0.002 mol), dimethyl phosphite (0.18 ml, 0.002 mol) and chitosan catalyst (10 molpercent) were taken in a reaction glass tube, degassed for 10 min and microwave irradiated at 180 W for 2 min at 60 °C. The progress of the reaction was monitored by TLC using petroleum ether and ethyl acetate (3:7) as solvent. After completion of the reaction, the mixture was diluted with ethyl acetate, washed with water (2 x 15 ml) followed by brine (1 x 10 ml), dried over Na2SO4 and evaporated to dryness. The crude mass was purified by column chromatography on silicagel (100-200 mesh) by using a 7:3 mixture of ethyl acetate in hexane to afford the pure alpha-aminophosphonates.
  • 3
  • [ 2591-86-8 ]
  • [ 636-98-6 ]
  • [ 6574-15-8 ]
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