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Chemical Structure| 1993-03-9 Chemical Structure| 1993-03-9
Chemical Structure| 1993-03-9

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Product Details of 2-Fluorophenylboronic acid

CAS No. :1993-03-9
Formula : C6H6BFO2
M.W : 139.92
SMILES Code : FC1=CC=CC=C1B(O)O
MDL No. :MFCD00674013
InChI Key :QCSLIRFWJPOENV-UHFFFAOYSA-N
Pubchem ID :2734354

Safety of 2-Fluorophenylboronic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of 2-Fluorophenylboronic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1993-03-9 ]
  • Downstream synthetic route of [ 1993-03-9 ]

[ 1993-03-9 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 76-09-5 ]
  • [ 1993-03-9 ]
  • [ 18107-18-1 ]
  • [ 517920-60-4 ]
YieldReaction ConditionsOperation in experiment
81%
Stage #1: at 60℃; for 4 h;
Stage #2: With tetrabutyl ammonium fluoride In tetrahydrofuran; 1,4-dioxane; water at 60℃; for 4 h;
To a 10 mL reaction tube equipped with a magnet was added 56 mg (0.4 mmol) of 2-fluorobenzeneboronic acid, 0.6 mL (1.2 mmol) of trimethylsilyl diazomethane (2 M n-hexane solution), 1 mL of toluene was added to the system, The rubber stopper was stoppered and reacted on an electromagnetic heating stirrer at 60 ° C for 4 hours.(0.4 mmol) of tetramethylammonium fluoride (1 M tetrahydrofuran solution) and 200 uL of water were added to an electromagnetic heating stirrer at 60 ° C On the reaction for 4 hours.After completion of the reaction, the organic solvent was removed by a rotary evaporator and purified by column chromatography2-fluorobenzyl boronic acid pinacol ester, its structure is as follows:The compound was a colorless liquid in a yield of 81percent and its NMR data was as follows:
References: [1] Patent: CN105884808, 2016, A, . Location in patent: Paragraph 0148; 0149; 0150; 0151; 0152; 0153.
  • 2
  • [ 14221-01-3 ]
  • [ 1993-03-9 ]
  • [ 886444-12-8 ]
References: [1] Patent: US2007/37974, 2007, A1, . Location in patent: Page/Page column 23.
 

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