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[ CAS No. 2001-28-7 ] {[proInfo.proName]}

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Chemical Structure| 2001-28-7
Chemical Structure| 2001-28-7
Structure of 2001-28-7 * Storage: {[proInfo.prStorage]}
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Product Details of [ 2001-28-7 ]

CAS No. :2001-28-7 MDL No. :MFCD00017215
Formula : C15H14O Boiling Point : -
Linear Structure Formula :- InChI Key :RDBAEHHVVNBKBB-UHFFFAOYSA-N
M.W : 210.27 Pubchem ID :228016
Synonyms :

Safety of [ 2001-28-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 2001-28-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2001-28-7 ]

[ 2001-28-7 ] Synthesis Path-Downstream   1~19

  • 1
  • [ 1217-45-4 ]
  • [ 127029-79-2 ]
  • [ 1468-28-6 ]
  • [ 2431-00-7 ]
  • [ 104-87-0 ]
  • [ 100-52-7 ]
  • [ 2001-28-7 ]
  • [ 63833-44-3 ]
  • 2
  • [ 7040-23-5 ]
  • [ 2001-28-7 ]
  • [ 74314-17-3 ]
  • [ 74314-18-4 ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; sodium hydride 1.) C6H6, 60 - 70 deg C, 2.) 3 h, reflux; Yield given. Multistep reaction. Yields of byproduct given;
  • 3
  • [ 7040-23-5 ]
  • [ 2001-28-7 ]
  • [ 74314-12-8 ]
  • [ 74314-12-8 ]
YieldReaction ConditionsOperation in experiment
58% With sodium hydride In benzene at 60 - 70℃; Yield given;
58% With sodium hydride In benzene at 60 - 70℃; Yields of byproduct given. Title compound not separated from byproducts;
  • 4
  • [ 3728-43-6 ]
  • [ 103-80-0 ]
  • [ 2001-28-7 ]
  • 5
  • [ 108-86-1 ]
  • [ 122-00-9 ]
  • [ 2001-28-7 ]
YieldReaction ConditionsOperation in experiment
86% With FibreCatTM 1000-D7; sodium tertiary butoxide In tetrahydrofuran at 85℃; for 6h;
83% With C16H14N6O4Pd; potassium-t-butoxide In acetonitrile at 82℃; for 2h; Schlenk technique; Reflux; Synthetic procedure for ketone a-arylations reaction General procedure: An oven-dried, resealable Schlenk tube containing a stirbar was charged with aryl halide (1.0 mmol), ketone(1.1 mmol), potassium tert-butoxide (1.5 mmol), and1.0 mol % catalyst. Acetonitrile (10 mL) was sequentiallyadded and the tube was backfilled with nitrogen, and themixture was stirred in an oil bath at reflux temperature forthe time specified. After the reaction was completed, thesolvent was removed on a rotary evaporator and the mixturewas purified by chromatography on silica gel. The pure product was obtained, and the yield was calculated basedon ArX.
72% With tris-(dibenzylideneacetone)dipalladium(0); bis[2-(diphenylphosphino)phenyl] ether; sodium tertiary butoxide In tetrahydrofuran at 70℃; for 3h; Sealed tube;
59% With bis[2-(diphenylphosphino)phenyl] ether; sodium tertiary butoxide In tetrahydrofuran at 70℃; for 3h; Inert atmosphere;
92 %Chromat. With potassium-t-butoxide In acetonitrile at 81℃; for 2h; Inert atmosphere; Schlenk technique; 2.7. Catalysis and recycling General procedure: The catalytic experiments were carried out using potassium tertbutoxide(1.5 mmol) as a base, functionalized silica materials (approx.Pd content 1.0 mol%) as catalyst, and ketone (1.0 mmol), and aryl halide(1.2 mmol) as reagents in acetonitrile (10 mL) at reflux temperature.After cooling the reaction mixture, the reaction vessel was centrifugedto settle the silica and the catalyst was separated from theliquid product by decanting the supernatant carefully and then filtration.The filtrate was analyzed by gas chromatography to determine theyield of the product. The recovered catalyst was washed twice withCH2Cl2 and dried in vacuo. It was then used for the next run.

  • 6
  • [ 5720-05-8 ]
  • [ 140-29-4 ]
  • [ 2001-28-7 ]
YieldReaction ConditionsOperation in experiment
99% With ammonium chloride In water at 100℃; for 24h;
97% With [2,2]bipyridinyl; palladium diacetate; trifluoroacetic acid In tetrahydrofuran; water at 80℃; for 36h; Inert atmosphere; Schlenk technique;
90% With [2,2]bipyridinyl; palladium diacetate; trifluoroacetic acid In tetrahydrofuran; water at 80℃; for 36h; Inert atmosphere; Schlenk technique;
86% In nitromethane for 24h; Heating;
84% With bathophenanthroline; water; copper diacetate; manganese(III) triacetate dihydrate In 1,4-dioxane at 90℃; General procedure for the synthesis of arylketones General procedure: In a 25mL round bottom flask (oven-dried overnight) was added the phenyl boronic acid (1a, 1.0 mmol) followed by the addition of 1,4-dioxane (6mL). To this solution, manganese (III) acetate. dihydrate (5mol%), Bphen (3e, 10mol%), Cu(OAc)2 (5mol%), nitrile (0.5mmol) and water (0.5mmol) were added sequentially. The reaction was then stirred at room temperature for 10min and slowly brought to 90°C under air. The reaction was allowed to run for overnight at the same temperature. After the completion, the reaction mixture was quenched and extracted with ethyl acetate and water. The organic layer was collected, and the aqueous layer was again extracted with ethyl acetate for three more times. The combined organic layer was further washed with sodium bicarbonate and brine solution. The organic layer was then dried over sodium sulfate, filtered and evaporated using rotavap. The crude compound obtained was further purified using column chromatography (EA:hexane 10:90).
81% With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; water; zinc(II) chloride In 1,4-dioxane at 80℃; for 8h; Inert atmosphere;
65% With [2,2]bipyridinyl; potassium fluoride; acetic acid In tetrahydrofuran at 80℃; for 48h;
With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; zinc(II) chloride In 1,4-dioxane; water at 80℃; for 8h; Inert atmosphere;

  • 7
  • [ 4706-43-8 ]
  • [ 2001-28-7 ]
  • 8
  • [ 111098-80-7 ]
  • [ 2001-28-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: di-isopropylamine, BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 1 h; 2.) room temp. 1 h 2: 95 percent / tetrahydrofuran / 1.) -78 deg C, 2 h; 2.) room temp. 1 h 3: 93 percent / 98percent H2SO4 / tetrahydrofuran / 0.25 h / Ambient temperature
  • 9
  • [ 5142-75-6 ]
  • [ 103-80-0 ]
  • [ 613-33-2 ]
  • [ 2001-28-7 ]
  • 10
  • [ 178686-24-3 ]
  • [ 57-13-6 ]
  • [ 2001-28-7 ]
  • [ 1283117-17-8 ]
YieldReaction ConditionsOperation in experiment
40% With hydrogenchloride; In ethanol; water;Reflux; 00161] A mixture of 2-phenyl-l-p-tolylethanone (65 mg, 0.31 mmol), 3-ethoxy-4- hydroxy-5-nitrobenzaldehyde (54 mg, 0.26 mmol), urea (56 mg, 0.93 mmol), andconcentrated HC1 solution (0.03 mL, 0.31 mmol) in EtOH (5 mL) was refluxed overnight. The mixture was evaporated in vacuo and the residue was purified by preparative HPLC to give compound 16 (455.19 mg, yield 40%). 1H NMR (DMSO- d6 400 MHz): delta 10.28 (s, 1H), 8.64 (s, 1H), 7.51 (s, 1H), 7.42 (s, 1H), 7.17 (s, 1H), 7.08-6.96 (m, 7H), 6.80 (d, J = 6.8 Hz, 2H), 5.14 (d, J = 2.4 Hz, 1H), 4.05-3.98 (m, 2H), 2.23 (s, 3H), 1.31 (t, J = 6.8 Hz, 3H); MS (ESI): m/z 446.2 [M+l]+.
  • 11
  • [ 2001-28-7 ]
  • [ 1889-71-0 ]
  • [ 36122-13-1 ]
  • [ 30856-48-5 ]
  • 1-(4-chlorophenyl)-2,3-diphenyl-4-p-tolylbutane-1,4-dione [ No CAS ]
  • 12
  • [ 2001-28-7 ]
  • [ 1889-71-0 ]
  • [ 96216-39-6 ]
  • [ 30839-22-6 ]
  • 2-(4-chlorophenyl)-3,4-diphenyl-5-p-tolylfuran [ No CAS ]
  • 13
  • [ 2001-28-7 ]
  • [ 1889-71-0 ]
  • 2-(4-chlorophenyl)-3,4-diphenyl-5-p-tolylfuran [ No CAS ]
  • 14
  • [ 2001-28-7 ]
  • [ 1889-71-0 ]
  • 1-(4-chlorophenyl)-2,3-diphenyl-4-p-tolylbutane-1,4-dione [ No CAS ]
  • 15
  • [ 452-62-0 ]
  • [ 201230-82-2 ]
  • [ 2001-28-7 ]
  • 6-methyl-3-phenyl-2-(p-tolyl)-4H-chromen-4-one [ No CAS ]
  • 16
  • [ 2431-00-7 ]
  • [ 2430-99-1 ]
  • [ 2001-28-7 ]
YieldReaction ConditionsOperation in experiment
1: 78% 2: 12% Stage #1: p-methylbenzil With sodium iodide In dichloromethane at 20℃; for 0.0833333h; Inert atmosphere; Green chemistry; Stage #2: With chloro-trimethyl-silane In dichloromethane at 20℃; for 18h; Inert atmosphere; Green chemistry; regioselective reaction;
  • 17
  • [ 720-94-5 ]
  • [ 88284-48-4 ]
  • [ 2001-28-7 ]
  • 18
  • [ 720-94-5 ]
  • [ 88284-48-4 ]
  • 9-(4-methylbenzoyl)-10-trifluoromethylphenanthrene [ No CAS ]
  • C18H15F3O3 [ No CAS ]
  • [ 2001-28-7 ]
  • 19
  • [ 3287-02-3 ]
  • [ 2430-99-1 ]
  • [ 2001-28-7 ]
YieldReaction ConditionsOperation in experiment
1: 67% 2: 28% With [(THD-Dipp)AuCl]; silver trifluoromethanesulfonate In 1,4-dioxane; water at 80℃; for 24h; Sealed tube; regioselective reaction;
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