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Chemical Structure| 202409-82-3 Chemical Structure| 202409-82-3

Structure of 202409-82-3

Chemical Structure| 202409-82-3

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Product Details of [ 202409-82-3 ]

CAS No. :202409-82-3
Formula : C12H9BrClNO
M.W : 298.56
SMILES Code : ClC1=CN=C(OCC2=CC=CC=C2)C(Br)=C1
MDL No. :MFCD18909515

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Application In Synthesis of [ 202409-82-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 202409-82-3 ]

[ 202409-82-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 138006-41-4 ]
  • [ 100-51-6 ]
  • [ 202409-82-3 ]
YieldReaction ConditionsOperation in experiment
With sodium hydride; In N,N-dimethyl-formamide; at 100℃; for 0.75h;Microwave irradiation; In a microwave tube NaH (60% in paraffin. 56 mg. 1.4 mmol) was washed with hexane and 3-bromo-2.5-dichloro-pyridine (245 mg. 1.08 mmol) in dry DMF (2 mL) were added. To this suspension BnOH (123 muL. 1.23 mmol) in dry DMF (1 mL) was dropped carefully. The reaction mixture was stirred 15 min until the formation of hydrogen has ceased. The tube was sealed and stirred at 100 C in a microwave reactor for 30 min. After removal of the solvent in vacuo the residue was partioned between water (10 mL) and DCM (10 mL) and extracted with DCM (3 x 10 mL). The combined organic fractions were washed with brine, dried overNa2SO4. filtered and concentrated in vacuo. The resulting title compound was used for the next reaction without purification. GC-MS (m/z): 297 [M+] .
  • 2
  • [ 4214-79-3 ]
  • [ 202409-82-3 ]
 

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