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Chemical Structure| 202823-67-4 Chemical Structure| 202823-67-4

Structure of 202823-67-4

Chemical Structure| 202823-67-4

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Product Details of [ 202823-67-4 ]

CAS No. :202823-67-4
Formula : C10H10Cl2N2
M.W : 229.11
SMILES Code : ClC1=NN=C(Cl)C2=C1C3CCC2CC3
MDL No. :MFCD01075667

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 202823-67-4 ]

[ 202823-67-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 325142-82-3 ]
  • [ 202823-67-4 ]
  • 1,4-di(m-trifluoromethylphenyl)-5,6,7,8-tetrahydro-5,8-ethanophthalazine [ No CAS ]
YieldReaction ConditionsOperation in experiment
91% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In tetrahydrofuran; water; at 100℃; for 12h;Inert atmosphere; 2.3 g (10 mmol) of 1,4-dichloro-5,6,7,8-tetrahydro-5,8-ethane pyridazine, 3.8 g (20 mmol) trifluoromethylThe phenylboronic acid and 1.4 g (10 mmol) of potassium carbonate were added to a 250 mL round bottom flask, 0.2 g (0.3 mmol) of PdCl2 (dppf) was added, then poured into 30 mL of tetrahydrofuran and 15 mL of water, protected with N2, and refluxed at 100C for 12 h. Cool, spin dry tetrahydrofuran, use twoChloroform extraction, the lower organic phase was obtained, spin-drying, and the silica gel column chromatography with the eluent of petroleum ether:ethyl acetate=1:1 to give 4.1 g of 1,4-bis(m-trifluoromethylphenyl)- 5,6,7,8-Tetrahydro-5,8-ethane pyridazine as a white solid in a yield of 91%.
 

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