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Chemical Structure| 204569-88-0 Chemical Structure| 204569-88-0

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Chemical Structure| 204569-88-0

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Product Details of [ 204569-88-0 ]

CAS No. :204569-88-0
Formula : C8H9NO
M.W : 135.16
SMILES Code : C=CC1=CC=CC(OC)=N1
MDL No. :MFCD18384343

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 204569-88-0 ]

[ 204569-88-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 54221-96-4 ]
  • [ 1779-49-3 ]
  • [ 204569-88-0 ]
YieldReaction ConditionsOperation in experiment
16% To a suspension of methyl(triphenyl)phosphonium bromide (7.07 g, 19.8 mmol, 1 .1 eq) in dry THF (50 ml) at 0°C is added n-butyl lithium (1.6M in cyclohexane, 12.5 ml, 19.8 mmol, 1 .1 eq). After stirring at 0°C for 20 minutes, a solution of 6-methoxypyridine- 2-carbaldehyde a1 -50 (2.5 g, 18 mmol, 1 eq) in dry THF (10 ml) is added dropwise to the mixture. The reaction mixture is warmed to room temperature for 30 minutes. The reaction mixture is quenched with 3 drops of water, and Rochelle salt is added (10 g). The mixture is filtered on Celite and MgSC>4. The crude residue is distilled to afford 400 mg of pure 2-ethenyl-6-methoxypyridine a1 -51.Yield: 16 percent.H NMR ? 7.51 (t, J = 7.6 Hz, 1 H), 6.82 (d, J = 7.2 Hz, 1 H), 6.72 (dd, J = 17.0, 10.6 Hz, 1 H), 6.62 (d, J = 8.2 Hz, 1 H), 6.29 (dd, J = 17.2, 1.4 Hz, 1 H), 5.41 (dd, J = 10.6, 1.4 Hz, 1 H), 3.96 (s, 3 H).
 

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