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CAS No. : | 54221-96-4 | MDL No. : | MFCD05664030 |
Formula : | C7H7NO2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | YDNWTNODZDSPNZ-UHFFFAOYSA-N |
M.W : | 137.14 | Pubchem ID : | 12325392 |
Synonyms : |
|
Num. heavy atoms : | 10 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.14 |
Num. rotatable bonds : | 2 |
Num. H-bond acceptors : | 3.0 |
Num. H-bond donors : | 0.0 |
Molar Refractivity : | 36.12 |
TPSA : | 39.19 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -6.46 cm/s |
Log Po/w (iLOGP) : | 1.33 |
Log Po/w (XLOGP3) : | 0.95 |
Log Po/w (WLOGP) : | 0.9 |
Log Po/w (MLOGP) : | -0.08 |
Log Po/w (SILICOS-IT) : | 1.48 |
Consensus Log Po/w : | 0.92 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -1.6 |
Solubility : | 3.44 mg/ml ; 0.0251 mol/l |
Class : | Very soluble |
Log S (Ali) : | -1.36 |
Solubility : | 5.99 mg/ml ; 0.0437 mol/l |
Class : | Very soluble |
Log S (SILICOS-IT) : | -2.07 |
Solubility : | 1.16 mg/ml ; 0.00849 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 1.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.41 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
To a solution of the compound of Preparation 113 (5.6 g, 29.8 mmol) in anhydrous tetrahydrofuran (100 ml), at -78° C. and under nitrogen, was added n-butyllithium (1.6M in hexane, 19.5 ml), via syringe. The mixture was stirred at -78° C. for 30 min, before addition of N,N-dimethylformamide (2.5 ml, 32.8 mmol). The reaction mixture was allowed to warm to room temperature and stirred for 18 h, before being acidified with sulphuric acid (2M) and then neutralised by addition of sodium hydrogen carbonate. The mixture was concentrated in vacuo and the residue was extracted with ethyl acetate (4*150 ml). The combined extracts were dried (MgSO4) and concentrated in vacuo to give the title compound (3.0 g). 1H-NMR (CDCl3): 4.01-4.05 (3H), 6.95-7.00 (1H), 7.54-7.58 (1H), 7.70-7.76 (1H), 9.95-9.98 (1H) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
EXAMPLE 8 N-[1-(6-methoxy-2-pyridylmethyl)piperidin-4-yl]-2-cyclopentyl-2-hydroxy-2-phenylacetamide STR12 Using as the starting material 13 mg of 6-methoxy-2-pyridinecarbaldehyde which had been synthesised following the method of D. L. Comins, et al. [J. Org. Chem. Vol. 55, pp. 69-73 (1990)] in a method similar to Step (3) of Example 2, 37 mg of the title compound was obtained as a colorless oily substance. FAB-MS (m/e, (C25 H33 N3 O3 +H)+): 424 1 H-NMR(CDCl3) delta: 1.10-1.75 (10H, m), 1.75-1.90 (2H, m), 2.15-2.30 (2H, m), 2.75-2.86 (2H, m), 2.95-3.08 (1H, m), 3.12 (1H, s), 3.55 (2H, s), 3.65-3.80 (1H, m), 3.90 (3H, s), 6.31 (1H, d, J=7.9 Hz), 6.59 (1H, d, J=8.2 Hz), 6.93 (1H, d, J=7.2 Hz), 7.22-7.38 (3H, m), 7.51 (1H, dd, J=7.2, 8.2 Hz), 7.56-7.62 (2H, m) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydroxide; In water; at 0 - 25℃; for 19h; | To a solution of the compound of Preparation 68 (1.0 g, 7.3 mmol) in acetone (3.2 ml, 43.8 mmol), at 0° C., was added aqueous sodium hydroxide solution (5M, 2.2 ml). The reaction mixture was stirred at 0° C. for 1 h and then at room temperature for 18 h. The mixture was acidified with hydrochloric acid (4M, 4 ml) and then neutralised with sodium hydrogen carbonate. The mixture was extracted with ethyl acetate and the combined organic extracts were concentrated in vacuo to give the title compound (1.4 g). 1H-NMR (CDCl3): 2.40-2.42 (3H), 3.89-3.94 (3H), 6.73-6.78 (1H), 6.98-7.02 (1H), 7.37-7.44 (1H), 7.48-7.61 (3H) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In tetrahydrofuran; for 4h;Inert atmosphere; Reflux; | Preparation of Example 72 - (3.pound.4fl)-iV-((y)-l-(6-methoxypyridin-2- yl)ethyl)-4-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide; (S)-I -(6-methoxypyridin-2-yl)ethanamine (51) was prepared by the following procedures.[0216] In a 250 mL of round bottom flask, equipped with Dean-Stark trap and a reflux condenser, 6-methoxypicolinaldehyde 45 (500 mg, 3.65 mmol), (S)-2 (+)- phenylglycinol 46 (500 mg, 3.65 mmol) and anhydrous THF (30 mL) were mixed and heated at reflux under argon for 4 h. (S,E)-2-((6-methoxypyridin-2-yl)methyleneamino)- 2-phenylethanol 47 was used directly in the next step without further purification.[0217] HDMS (470 mg, 2.92 mmol), (NH4)2SO4 (53 mg, 0.4 mmol) and anhydrous THF (15 mL) were added to compound 47 (934 mg, 3.65 mmol). The reaction mixture was heated at 800C for 2 h under argon. Then the solvent was removed in vacuo to afford crude (S,E)-N-((6-methoxypyridin-2-yl)methylene)-l-phenyl-2-(trimethylsilyloxy)ethanamine 48 (1.2 g).[0218] In a 100 mL of round bottom flask (flame-dried), at -78 "C, were added anhydrous THF (10 mL) and CH3MgBr (3.0 M in Et2O, 3.5 mL). At -50 0C, compound 48 (1.2 g, 3.65 mmL) in anhydrous THF (10 mL) was added dropwise. The reaction mixture was stirred at -40 0C for 1 h, and at rt. for 1 h. The reaction was then quenched with a cold, sat. NH4Cl with stirring at 00C. EtOAc was added and layers were separated. The organic layer was concentrated to afford (S)-N-((S)-l-(6-methoxypyridin- 2-yl)ethyl)-l-phenyl-2-(trimethylsilyloxy)ethanamine 49 (1 g).[0219] A solution of compound 49 (1 g, 0.29 mmol) in THF was cooled to 0 °C, H2SO4 (2.5 M, 5 rnL) was added dropwise with stirring. The resulting mixture was stirred at rt. for 2 h. The mixture was basified with 2N NaOH at 0 °C and extracted with EtOAc (3 x 30 mL). Combined organic layers were dried over Na2SO4 and concentrated. The residue was purified with flash column (eluted with 30percent EtOAc/hexane) to give (S)- 2-((S)-l-(6-methoxypyridin-2-yl)ethylamino)-2-phenylethanol 50 (860 mg).[0220] Methylamine in water (40 percent in water, 10 mL) was added to a solution of compound 50 (860 m g, 3.16 mmol) in MeOH (15 mL). At 0 0C, H5IO6 (4.33 g,) in water (15 mL) was added dropwise. White precipitates were formed. The resulting mixture was stirred at rt overnight. EtOAc and water were added. Organic layer was separated, and aq. layer was extracted with EtOAc. Combined organic layers were concentrated. The crude product was purified by prep. HPLC to give (S)-I -(6- methoxypyridin-2-yl)ethanamine 51 (80 mg).[0221] Data for compound 51: 1H NMR (400 MHz, CD3OD) delta 7.62 (t, IH), 6.89 (d, IH), 6.64 (d, IH), 3.97 (m, IH), 3.90 (s, 3H), 1.42 (d, 3H). The above method can be used to prepare other chiral amines. For examples, the chiral amines used in Example 117, 118 and 120. Example 72[0223] Example 72 was prepared from (-)-5 (prepared from Procedure K) and (S)-l-(6-methoxypyridin-2-yl)ethanamine 51 using the similar procedures in Example 96. 1H NMR Data for Example 72 (see Table 5). Preparation of Example 91 - (3S,4R)-4-(3,4-dichlorophenyl)-N-((S)-l-(3- methoxyphenyl)ethyl)pyrrolidine-3-carboxamide |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
47% | LiHMDS (2.45 mL, 1.2 M in THF, 2.94 mmole) was added to a flame-dried round bottom flask. The mixture was cooled to 00C then <strong>[54221-96-4]6-methoxypyridine-2-carbaldehyde</strong> (Comins, Daniel L.; Killpack, Michael O. J.Org.Chem. 1990, 55, 69-73, 161 mg, 1.18 mmole) was added. After 30 minutes di-3-pyridylmethane (200 mg, 1.18 mmole) in dry THF (2.0 mL) was added. After 2 hr the mixture was warmed to RT, quenched with saturated NH4Cl, and extracted with CH2Cl2(3x) and iBuOH (2x). The combined organic layers were dried (MgSO4), filtered, and concentrated. The residue was taken up in MeOH (5 mL) and H2NOH (0.4 mL, 50percent in H2O) was added. After 18 hr the mixture was concentrated. Flash column (gradient, 0-10percent MeOH/CH2Cl2) gave l-(6-methoxypyridin-2-yl)-2,2-dipyridin-3- ylethanamine as a pale yellow oil (168 mg, 47percent): 1H-NMR (500 MHz, CDCl3) delta 8.64 (d, J = 1.95 Hz, 1 H), 8.51 (dd, J = 1.46 and 3.17 Hz, 1 H), 8.36 (d, J = 1.95 Hz, 1 H), 8.32 (dd, J = 1.46 and 3.18 Hz, 1 H), 7.76 (d, J = 7.82 Hz, 1 H), 7.49 (d, J = 8.06 Hz, 1 H), 7.37-7.27 (m, 2 H), 7.09 (m, 1 H), 6.56 (d, J = 7.08 Hz, 1 H), 6.52 (d, J = 7.81 Hz, 1 H), 4.59 (d, J = 9.28 Hz, 1 H), 4.42 (d, J = 9.28 Hz, 1 H), 3.91 (s, 3 H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94% | In toluene; at 60℃; | EXAMPLE 26; S-C-Methoxypyridin^-yO-N'-CCS-methylquinolin-- yl)methylene)propanehydrazide; [0547] (a) (E)-Methyl 3-(6-methoxypyridin-2-yl)acrylate: To a stirred solution of <strong>[54221-96-4]6-methoxypyridine-2-carboxaldehyde</strong> (0.35 mL, 2.9 mmol) in toluene was added methyl (triphenylphosphoranylidene) acetate (1.95 g, 5.8 mmol) and the reaction was heated at 60 0C overnight. The reaction was diluted with EtOAc and washed with water, brine and dried (Na2SO4). Purification on silica gel using EtOAc-hexane (0 to 30percent) provided 530 mg (94percent) of the desired product. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
97% | With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; piperdinium acetate; In toluene; at 105℃; for 3h;Inert atmosphere; | The general procedure for the synthesis of the 3-aminoindolizine derivatives 1a-e, 6a-g, and uncyclized product 8a-c is described below: To a reaction mixture of cyano substrate 3 (2.0 mmol), 2-carbonyl pyridine derivative (2.0 mmol), and piperidinium acetate (15 mg, 0.10 mmol) in toluene (6 ml), was added diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate (9) (Hantzsch ester, 557 mg, 2.2 mmol) in one portion at room temperature. The resulting mixture was degassed with a stream of nitrogen and then stirred at 105 °C for 3 h. After cooling to room temperature, a minimum amount (ca 0.3-0.5 mL) of DMSO was added to the reaction mixture and the resulting solution was directly loaded to a silica gel column and purified by column chromatography using Teledyne Isco Combiflash system. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
(1)A solution of methylpiperazine (2.31 g) in tetrahydrofuran (20 mL) was cooled to -78° C., and n-butyllithium (2.64 M, 7.55 mL) was added dropwise in an argon gas atmosphere.After stirring at the same temperature for 15 minutes, a solution of 6-methoxypicolinaldehyde (2.5 g) in tetrahydrofuran was added and the mixture was stirred for 30 minutes. t-Butyllithium (1.59 M, 17.1 mL) was added dropwise to the reaction solution, and the mixture was stirred at the same temperature for one hour and at -40° C. for 15 minutes.The reaction solution was cooled again to -78° C. A solution of hexachloroethane (12.9 g) in tetrahydrofuran (20 mL) was slowly added dropwise, and the mixture was stirred at the same temperature for 30 minutes.The reaction solution was poured into water, followed by extraction with ethyl acetate.The organic layer was washed with brine, dried over anhydrous magnesium sulfate and filtered, after which the filtrate was concentrated under reduced pressure.The resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=20:1?10:1) to give 5-chloro-<strong>[54221-96-4]6-methoxypyridine-2-carbaldehyde</strong> as a colorless powder (1.21 g). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium acetate; acetic anhydride; In water; | Example 84-((6-Methoxy-2-pyridinyl)methylene)-2-(2-thienyl)-5(4H)-oxazoloneTo a screw-capped test tube, N-(2-thienylcarbonyl)glycine (56 mg, 0.3 mmol), <strong>[54221-96-4]6-methoxy-2-pyridinecarboxaldehyde</strong> (46 mg, 0.3 mmol), sodium acetate (25 mg, 0.3 mmol) and acetic anhydride (0.3 mL) were added.The test tube was sealed, and it was then stirred at an external temperature of 90° C.Three hours later, the temperature of the reaction solution was returned to room temperature, and water (1.5 mL) was then added thereto.The obtained mixture was stirred at the same temperature as described above for 1.5 hours.Thereafter, the precipitated crystal was collected by filtration, and it was washed with water (5 mL) and was then dried under reduced pressure, so as to obtain 38 mg of the above-captioned compound.1H-NMR (400 MHz, DMSO-d6, delta).8.25 (d, J=7.1 Hz, 1H), 8.18 (d, J=4.9 Hz, 1H), 8.03 (d, J=3.8 Hz, 1H), 7.91 (d, J=7.9 Hz, 1H), 7.38 (dd, J=3.8, 4.9 Hz, 1H), 6.99 (s, 1H), 6.91 (d, J=7.9 Hz), 3.92 (s, 6H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In toluene; at 70℃; for 12h;Molecular sieve; | General procedure: A vial was charged with aldehyde or imidate (0.085 mmol), amine, amino alcohol or diamine or (0.085 mmol) and anhydrous toluene (0.4 mL). To this was added 4A molecular sieves and the vial was sealed. The reaction was then stirred at 70 °C for 12 h. Mixtures were then added directly to the catalytic reaction. In cases where ligands were synthesised prior to the reaction then the same procedure was followed, and ligands were purified by column chromatography prior to use.#10; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In toluene; at 70℃; for 12h;Molecular sieve; | General procedure: A vial was charged with aldehyde or imidate (0.085 mmol), amine, amino alcohol or diamine or (0.085 mmol) and anhydrous toluene (0.4 mL). To this was added 4A molecular sieves and the vial was sealed. The reaction was then stirred at 70 °C for 12 h. Mixtures were then added directly to the catalytic reaction. In cases where ligands were synthesised prior to the reaction then the same procedure was followed, and ligands were purified by column chromatography prior to use.#10; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In toluene; at 70℃; for 12h;Molecular sieve; | General procedure: A vial was charged with aldehyde or imidate (0.085 mmol), amine, amino alcohol or diamine or (0.085 mmol) and anhydrous toluene (0.4 mL). To this was added 4A molecular sieves and the vial was sealed. The reaction was then stirred at 70 °C for 12 h. Mixtures were then added directly to the catalytic reaction. In cases where ligands were synthesised prior to the reaction then the same procedure was followed, and ligands were purified by column chromatography prior to use.#10; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In toluene; at 70℃; for 12h;Molecular sieve; | General procedure: A vial was charged with aldehyde or imidate (0.085 mmol), amine, amino alcohol or diamine or (0.085 mmol) and anhydrous toluene (0.4 mL). To this was added 4A molecular sieves and the vial was sealed. The reaction was then stirred at 70 °C for 12 h. Mixtures were then added directly to the catalytic reaction. In cases where ligands were synthesised prior to the reaction then the same procedure was followed, and ligands were purified by column chromatography prior to use.#10; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
16% | To a suspension of methyl(triphenyl)phosphonium bromide (7.07 g, 19.8 mmol, 1 .1 eq) in dry THF (50 ml) at 0°C is added n-butyl lithium (1.6M in cyclohexane, 12.5 ml, 19.8 mmol, 1 .1 eq). After stirring at 0°C for 20 minutes, a solution of 6-methoxypyridine- 2-carbaldehyde a1 -50 (2.5 g, 18 mmol, 1 eq) in dry THF (10 ml) is added dropwise to the mixture. The reaction mixture is warmed to room temperature for 30 minutes. The reaction mixture is quenched with 3 drops of water, and Rochelle salt is added (10 g). The mixture is filtered on Celite and MgSC>4. The crude residue is distilled to afford 400 mg of pure 2-ethenyl-6-methoxypyridine a1 -51.Yield: 16 percent.H NMR ? 7.51 (t, J = 7.6 Hz, 1 H), 6.82 (d, J = 7.2 Hz, 1 H), 6.72 (dd, J = 17.0, 10.6 Hz, 1 H), 6.62 (d, J = 8.2 Hz, 1 H), 6.29 (dd, J = 17.2, 1.4 Hz, 1 H), 5.41 (dd, J = 10.6, 1.4 Hz, 1 H), 3.96 (s, 3 H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With piperidine; In ethanol; at 20℃; for 18h; | General procedure: The amide 6 from the step1 reaction (5.0mmol), aldehyde 7 (5mmol), and piperidine (five drops) were added and stirred in anhydrous ethanol (10mL). Ethanol was evaporated and solid was triturated with water and dried under high vacuum to give the desired product 8. |
Tags: 54221-96-4 synthesis path| 54221-96-4 SDS| 54221-96-4 COA| 54221-96-4 purity| 54221-96-4 application| 54221-96-4 NMR| 54221-96-4 COA| 54221-96-4 structure
[ 52090-56-9 ]
6-Methoxy-2-methylpyridin-3-amine
Similarity: 0.81
[ 2172852-89-8 ]
(6-Methoxypyridin-2-yl)methanamine dihydrochloride
Similarity: 0.81
[ 52090-56-9 ]
6-Methoxy-2-methylpyridin-3-amine
Similarity: 0.81
[ 2172852-89-8 ]
(6-Methoxypyridin-2-yl)methanamine dihydrochloride
Similarity: 0.81
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P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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