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Structure of 207853-60-9

Chemical Structure| 207853-60-9

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Product Details of [ 207853-60-9 ]

CAS No. :207853-60-9
Formula : C8H5F4NO
M.W : 207.13
SMILES Code : O=C(N)C1=CC=CC(C(F)(F)F)=C1F
MDL No. :MFCD00061146
InChI Key :UHMUBYIIPNQHGD-UHFFFAOYSA-N
Pubchem ID :605688

Safety of [ 207853-60-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 207853-60-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 207853-60-9 ]

[ 207853-60-9 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 207853-60-9 ]
  • [ 611-32-5 ]
  • 2-fluoro-N-(quinolin-8-ylmethyl)-3-(trifluoromethyl)benzamide [ No CAS ]
  • 2
  • [ 392-85-8 ]
  • [ 207853-60-9 ]
  • 3
  • [ 115029-22-6 ]
  • [ 207853-60-9 ]
  • 4
  • [ 208173-19-7 ]
  • [ 207853-60-9 ]
YieldReaction ConditionsOperation in experiment
91.9% With ammonium hydroxide; In tetrahydrofuran; at 2℃; for 2h; c. Add 20mL of 25% ammonia water into the reactor, set the temperature to 2, and then dissolve 1.5g of compound C in 20mL of tetrahydrofuran, drop it into the reactor, stir for 2h, and carry out the mixture in the reactor. After suction filtration, the filter cake was washed with water and dried to obtain 1.26 g of compound D, which is 2-fluoro-3-trifluoromethylbenzamide, with a yield of 91.9% and a purity of 95.9%.
  • 5
  • [ 207853-60-9 ]
  • 2-fluoro-3-(trifluoromethyl)aniline [ No CAS ]
YieldReaction ConditionsOperation in experiment
96.4% d. Add 1.2g of compound D and 12mL of ethanol to the reaction flask, stir to dissolve, then add 5.0g of 20% sodium hydroxide solution by mass fraction, stir for 40min, control the temperature at 0, add 20mL of aqueous solution containing 1.8g of sodium hypochlorite, and stir 1h, warm to 80C, keep for 5h, cool to room temperature, extract with ethyl acetate, wash with water, dry with anhydrous sodium sulfate, and concentrate to obtain 1g of compound E, which is 2-fluoro-3-trifluoromethylaniline. The rate is 96.4%, and the purity is 97.2%.
  • 6
  • [ 207853-60-9 ]
  • 1-chloro-2-fluoro-3-(trifluoromethyl)benzene [ No CAS ]
  • 7
  • [ 207853-60-9 ]
  • 2-chloro-3-fluoro-4-(trifluoromethyl)benzaldehyde [ No CAS ]
 

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