* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
With potassium fluoride In N,N-dimethyl-formamide at 140 - 160℃;
In the solution prepared in step (3)29.0 g of KF was charged under stirring,And then incubating the mixture at a temperature of 140-160 DEG C until the content of 2,3,4-trichlorobenzonitrile reaches 2percent(5) under normal pressure to do spin-drying solvent DMF,The resulting brown-yellow granular solid was recrystallized by dissolving 200 mL of toluene,Cooling to about 0 overnight,Filtration,And dried to give 33.8 g of 3-chloro-2,4-difluorobenzonitrile as a pale yellow granular solid in an amount of 98.637percent (GC) in a molar yield of 65.0percent Benzene);
Reference：
[1] Patent: CN106278860, 2017, A, . Location in patent: Paragraph 0023; 0028; 0029
Stage #1: 2,3,4-trichloroaniline With hydrogenchloride; sodium nitrite
Stage #2: potassium cyanide With copper(l) cyanide In water at 20℃; for 0.333333h;
With potassium fluoride; In N,N-dimethyl-formamide; at 140 - 160℃;
In the solution prepared in step (3)29.0 g of KF was charged under stirring,And then incubating the mixture at a temperature of 140-160 DEG C until the content of 2,3,4-trichlorobenzonitrile reaches 2%(5) under normal pressure to do spin-drying solvent DMF,The resulting brown-yellow granular solid was recrystallized by dissolving 200 mL of toluene,Cooling to about 0 overnight,Filtration,And dried to give 33.8 g of 3-chloro-2,4-difluorobenzonitrile as a pale yellow granular solid in an amount of 98.637% (GC) in a molar yield of 65.0% Benzene);
Chemistry
Pharmaceutical Intermediates
Inhibitors/Agonists
Material Science
For Research Only
110K+ Compounds
Competitive Price
1-2 Day Shipping
